DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	122/565 - (21%)
Similarity:	211/565 - (37%)	Gaps:	109/565 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VILLLALALVLGCYCALHRHKLADIYLRPLLKNTLLEDFYHAELIQPEAPKRRRRGIWDIPGPKR 67
            |:.||.:||.:|.:....|:.                  |..           ||||..  .|.|
  Fly     4 VVALLLIALAVGFWFVRTRYS------------------YWT-----------RRGIGS--EPAR 37

  Fly    68 IPFLGTKWIFLLFFRRYK-----MTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEKVL 127
            .| :|.    :..||:.|     :|.::|.:......:....:.:.|  |.:|     .|||..
  Fly    38 FP-VGN----MEGFRKNKHFIDIVTPIYEKFKGNGAPFAGFFMMLRP--VVLV-----TDLELA- 89

  Fly   128 KYPSKYPFRPPTEIIV----------MYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRV 182
                       .:|::          ||...|.|.... .:....||.|:.||..::.:.||.::
  Fly    90 -----------KQILIQDFANFEDRGMYHNERDDPLTG-HLFRIDGPKWRPLRQKMSPTFTSAKM 142

  Fly   183 LQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGR-RMGFLAIDTKQP 246
            ...|    ..||:...||.:...:.....:....|:.:||.  ...:.::|| ..|......:.|
  Fly   143 KYMF----PTVCEVGEELTQVCGELADNAMCGILEIGDLMA--RYTSDVIGRCAFGVECNGLRNP 201

  Fly   247 QKISQLAAAVKQLFISQRDSYYGLGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAA 311
            :  ::.|...::.|..:|......|..:.||  ....|.|...:..|:....:....|.:|
  Fly   202 E--AEFAIMGRRAFSERRHCKLVDGFIESFP--EVARFLRMRQIHQDITDFYVGIVRETVK---- 258

  Fly   312 CEDDEAAGLRSIFLNIL-ELK---DLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMP 372
             :.:|...:||.|:|:| |:|   :|.|.:..:....|.|||.:|.|:||.|.|..:...|....
  Fly   259 -QREEQGIVRSDFMNLLIEMKQRGELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQA 322

  Fly   373 RILSEF---CEYRDTNILQDALTNATYTKACIQESYRLRPTAFCLARILEEDMELSG---YSLNA 431
            ::..|.   ....:.....|::....|.:..|.|:.|..|....|.||........|   :.:..
  Fly   323 KLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEP 387

  Fly   432 GTVVLCQNMIACHKDSNFQGAKQFTPERWI-DPATENFTVNVDNASIVVPFGVGRRSCPGKRFVE 495
            |.::|.......|..:.:....:|.|||:: |...:..|      :..:|||.|.|:|.|.||.:
  Fly   388 GQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPT------AAWLPFGDGPRNCIGMRFGK 446

  Fly   496 MEVVLLLAKMVLAFDVSFVKPLETEFEF-----LLAPKTPLSLRL 535
            |:..:.|..::..|..|.....:.:.||     ||.|...:.|::
  Fly   447 MQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	108/496 (22%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	110/501 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910