DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shd and Cyp313a2

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	113/564 - (20%)
Similarity:	208/564 - (36%)	Gaps:	131/564 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVI-LLLALALVLGCYCALHRHKLADIYLRPLLKNTLLEDFYHAELIQPEAPKRRRRGIWDIPG 64
            |.|| ||:|.:|:|.......|.||..:.::                               :||
  Fly     1 MIVIQLLIAASLILWIRFLWSRRKLYMLMMQ-------------------------------LPG 34

  Fly    65 PKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEKVLKY 129
            ...:|.||....:|:..|....::  ..|.|   ::|...:..: ...|||...:....||||..
  Fly    35 RMGLPLLGNSVRYLIISRGRMSSR--TTYMD---KHGSTYMAWI-GTTPIVITRDPKIAEKVLTS 93

  Fly   130 PSKYPFRPPTEIIVMYRQSRPDRYASV----GIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPAL 190
            |           ..:.|.|:.....::    |::..||..|...|..:..:. ...||.:|||..
  Fly    94 P-----------FCINRSSQTTNALALSMGYGLLTLQGSKWMARRKHMNPAF-KHSVLLSFLPIF 146

  Fly   191 NA-------VCDDFI---------ELLR--------ARRDPDTLVVPNFEELANLMGLEAVCTLM 231
            ||       |.|.|:         :|:|        .....|.....|||..|.|...:::..|.
  Fly   147 NAETDLLVSVFDSFVGQGEKDVLSDLIRWSFAIATQTTLGTDVTKDDNFENDAILKTYQSMLRLT 211

  Fly   232 LGRRMGFLAIDTKQPQKISQLAAAVKQLFISQRDSYYGLGLWKYFPTKTYRDFARAED--LIYDV 294
            :                |:.....|:...:|:   .:||            ::.|..|  .|..:
  Fly   212 I----------------INIFVPFVQNKIVSK---LFGL------------EWLRRRDASAINKM 245

  Fly   295 ISEIIDHELEELKKSAACEDDEAAGLRSIFLNILEL---KDLDIRDKKSAIIDFIAAGIETLANT 356
            |:.|:|.:|....:: .||.:    |:::....:||   .::.:.:..:.....:.|..||.|:|
  Fly   246 INNILDKKLNSNPEN-YCESE----LKTVIHRAIELFRNDEMSLMELGAECSSMVLAAFETSAHT 305

  Fly   357 LLFVLSSVTGDPGAMPRILSEFCEY----RDTNILQDALTNATYTKACIQESYRLRPTAFCLARI 417
            :.:.|..:...|.....:.:|..|:    :...:....|....|....:.|:.||.|:....:|.
  Fly   306 VYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNETLRLMPSVPFSSRE 370

  Fly   418 LEEDMELSGYSLNAGTVVLCQNMIACHKDSNFQG--AKQFTPERWIDPATENFTVNVDNASIVVP 480
            ..||:.||...:....:.:..::....:::::.|  |.||.||.::..     .::..:....:|
  Fly   371 TLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPE-----KIHDRHPYAFIP 430

  Fly   481 FGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVSFVKPLETEFEFL 524
            |..|:|:|.|.|:..|...|.|.|::..:.:....|.| ..||:
  Fly   431 FSKGKRNCIGWRYGLMSSKLALVKILRNYKLKTSFPYE-NLEFV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	102/501 (20%)
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	98/488 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100