Protein Alignment shd and cyp27a1.1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_002663445.1
• Gene: cyp27a1.1 / 402831
• ZFINID: ZDB-GENE-081104-519
• Length: 524
• Species: Danio rerio
• Alignment Length: 563
• Identity: 140/563 - (24%)
• Similarity: 244/563 - (43%)
• Gaps: 69/563 - (12%)

  Fly     1 MAVILLLALALVLGCYCALHRHKLADIYLRPLLKNTLLEDFYHAELIQPEAPKRRRRGIWDIPGP 65
            |||...|:.|..||......|...|....|....|..      |..:..:...|:.:...|:|..
Zfish     1 MAVCFALSSAERLGIGLGFLRPTAAATGFRRAAGNAA------AASVSVQDGHRKLKTEADLPEI 59

  Fly    66 KRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEKVLKYP 130
            |....|     :.|.|:.| ::::||:.....:.||.: .::...|...|.|.:.|.||::|:..
Zfish    60 KIFTML-----YRLLFKGY-LSRMHELQLYEKQLYGPL-YKINVGNFQSVALNSVDLLEELLRKD 117

  Fly   131 SKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPALNAVCD 195
            .|:|.|....:...||..:...|   |...|:|..|.:||:.|...:..|:....:...:|||..
Zfish   118 EKFPSRGDMTLWTEYRDMKGIGY---GPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVIT 179

  Fly   196 DFIELLRARRD--PDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQKISQLAAAVKQ 258
            |||:.:...|:  |...:|.|.........||.:.:::...|:|  .::.:.|.:......::.|
Zfish   180 DFIKRIYYLREMSPTGDLVSNLTNELYRFSLEGISSILFETRIG--CLEKEIPAETQHFINSIAQ 242

  Fly   259 LFISQRDSYYGLGL-----W--KYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACEDDE 316
            :..      |.:.:     |  .|.|  .::.:....|.|:....::||.::|.|:|.... :.|
Zfish   243 MLT------YSMPVVFMPNWTRNYLP--FWQRYIGGWDGIFKFAGKMIDMKMEALQKRVDA-NQE 298

  Fly   317 AAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEFCEY 381
            .||....:|  |....:..:|...::.:.:.||::|.:||:||.|..::.||.....:..|.
Zfish   299 VAGEYLTYL--LSNGKMSSKDVYGSVSELLLAGVDTTSNTMLFALYHLSKDPETQDILYQEV--- 358

  Fly   382 RDTNILQD-------ALTNATYTKACIQESYRLRPTAFCLARIL-EEDMELSGYSLNAGTV-VLC 437
              ||:|:|       .:...:|.||.|:|:.||.|.....||:: |.::.:.|:.....|. .||
Zfish   359 --TNVLKDDRIPTAQEVNTMSYLKAVIKETLRLYPVVPMNARLIAENEVVIGGHLFPKNTTFTLC 421

  Fly   438 QNMIACHKDSNFQGAKQFTPERWI-DPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLL 501
            ...|: ..:..|...::|.||||: |..|.      .|....:|||.|.|.|.|:|..|:|:.|.
Zfish   422 HYAIS-RDEKVFPEPQKFKPERWLRDGRTR------PNPFGSIPFGFGVRGCVGRRIAELEMYLA 479

  Fly   502 LAKMVLAFDVSFVKPLETEFEF------LLAPKTPLSLRLSDR 538
            ||:::..|:   ::|..|..|.      :|||...::|...:|
Zfish   480 LARLIKLFE---IRPDPTVGEVRSLNRTVLAPDRKVNLHFVER 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	116/458 (25%)
cyp27a1.1	XP_002663445.1	cytochrome_P450	85..514	CDD:477761	116/460 (25%)