DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and Cyp12b2

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	135/509 - (26%)
Similarity:	232/509 - (45%)	Gaps:	55/509 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RRRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDI-VLEVMPSNVPIVHL 117
            ::.|...:||||..:..|.    |.:.....:.|.|.::...:...|||| .:..|......|..
  Fly    48 QQARSFGEIPGPSLLRMLS----FFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFT 108

  Fly   118 YNRDDLEKVLKYPSKYPFRPPTEIIVMYRQ-SRPDRYASV-GIVNEQGPMWQRLRSSLTSSITSP 180
            ||.||.|...:....:|.|...|.:..||: .|||.:..| |:.::||..|..:|:.:...:...
  Fly   109 YNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKV 173

  Fly   181 RVLQNFLPALNAVCDDFIELLRARRDPDT-LVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTK 244
            :.::..||.|:.:..:||:.|..:|:|:| .:..:|.....:...|::..:.|..|||.|: |..
  Fly   174 QNVRQNLPQLDQISKEFIDKLETQRNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLS-DNP 237

  Fly   245 QPQKISQLAAAVKQLFISQRDSYYGLGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKS 309
            .| ...:||..::..|...........:|.::.|..::.|.:..|.|.|:.|..|:..:....|:
  Fly   238 DP-NADRLAKHMRDFFNYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDITSNYIETAMRGFGKN 301

  Fly   310 AACEDDEAAGLRSIFLNILELKDLDIRDKKSA---IIDFIAAGIETLANTLLFVLSSVTGDPGAM 371
                ||  ...:.:...:||      .:||.|   ::|.:.|||:|.::..|.:|..:..:|...
  Fly   302 ----DD--GKTKCVLEQLLE------HNKKVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQ 354

  Fly   372 PRILSEFCEYRDTNILQDALT-----NATYTKACIQESYR---LRPTAFCLARILEEDMELSGYS 428
            .::..|......|.  :|:||     |..|.:|||:|..|   :.|..|   ||..:|:.||||.
  Fly   355 EKLRRELLRILPTT--KDSLTDQNTKNMPYLRACIKEGLRITSITPGNF---RITPKDLVLSGYQ 414

  Fly   429 LNAGTVVLCQNMIACHKDSNFQGAKQFTPERWID----------PATENFTVNVDNASIVVPFGV 483
            :..||.||...:...:.|..|..:.:|.||||:.          ||     ....|..:.:|||.
  Fly   415 VPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPA-----ARTRNPFVYLPFGF 474

  Fly   484 GRRSCPGKRFVEMEVVLLLAKMVLAFDVSFV--KPLETEFEFLLAPKTPLSLRL 535
            |.|:|.|||..|:|:..||.:::.::.||::  .|:|.|...:|:|...:..:|
  Fly   475 GPRTCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYESTIILSPCGDIRFKL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	131/491 (27%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	126/479 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920