Protein Alignment shd and Cyp49a1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_610588.2
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Alignment Length: 514
• Identity: 131/514 - (25%)
• Similarity: 244/514 - (47%)
• Gaps: 44/514 - (8%)

  Fly    51 APKRRRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIV-LEVMPSNVPI 114
            :|....|...::|||..:|.:|..|.|......||::.|.:|..:|:..||.:. :..:..:..:
  Fly    92 SPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKMAKVGGLIGHPDL 156

  Fly   115 VHLYNRDDLEKVLKYPSKYPFRPPTEIIVMYR-QSRPDRYASV-GIVNEQGPMWQRLRSSLTSSI 177
            :.:::.|::..:.|.....|.||....:..|: ..|.|.:..| |::...||.|:..|..:...:
  Fly   157 LFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHIL 221

  Fly   178 TSPRVLQNFLPALNAVCDDF---IELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFL 239
            ..|:..:.::|.||.:..:|   |||:|..:|.   :..||........||:|..:.|..|:|.|
  Fly   222 LQPQTAKKYIPPLNDIASEFMGRIELMRDEKDE---LPANFLHELYKWALESVGRVSLDTRLGCL 283

  Fly   240 AIDTKQPQKISQLAAAVKQLFISQRDSYYGLGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELE 304
            :  .:..::..|:..|:...|.:..:....:.||:.:|||.||.|.:|.|....:..:.|...::
  Fly   284 S--PEGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSFVKALDQFTAICMKNIGKTMD 346

  Fly   305 ELKKSAACEDDEAAGL--RSIFLNILELKDLDIRDKKSAII---DFIAAGIETLANTLLFVLSSV 364
            :      .:.|||.||  ....::|:|.......::|.|.|   |....|::|.:......:..:
  Fly   347 K------ADADEARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQL 405

  Fly   365 TGDPGAMPRILSEFCE---YRDTNILQDALTNATYTKACIQESYRLRPTAFCLARILEEDMELSG 426
            ..:|....::..|..:   :|:.:|.|:.|....|.:||::|:.|:||......|.|:.|..::|
  Fly   406 AKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVING 470

  Fly   427 YSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNAS------IVVPFGVGR 485
            |.:..||.|:..:::..:..:.|...|:|.||||:..:|:  .....:|:      :.:|||.||
  Fly   471 YHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTD--AAGCPHANQKIHPFVSLPFGFGR 533

  Fly   486 RSCPGKRFVEMEVVLLLAKMVLAFDVSFVKPLETEFEFL------LAPKTPLSLRLSDR 538
            |.|.|:||.|:|:..||||:...:.||:     ...||:      ..|::||:.:|:.|
  Fly   534 RMCVGRRFAEIELHTLLAKIFRKYKVSY-----NSGEFVYRVNSTYIPQSPLNFKLTLR 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	114/459 (25%)
Cyp49a1	NP_610588.2	CYP24A1-like	138..581	CDD:410677	114/460 (25%)