DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and Cyp11b3

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_861545.1	Gene:	Cyp11b3 / 353498	RGDID:	727886	Length:	498	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	125/564 - (22%)
Similarity:	221/564 - (39%)	Gaps:	129/564 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ADIYLRP--LLKNTLLEDFYHAELIQPEAPKRRRRGIWDIPGPKRI-PFLG------TKWIFLL- 79
            ||::.||  .|..|                  |..|......||.: ||..      .||:.::
  Rat     7 ADVWARPWQCLHRT------------------RALGSTATQAPKTLKPFEAIPQYSRNKWLKMIQ 53

  Fly    80 FFRRYKMTKLHEVYADLNRQYGDI--VLEVMPSNVPIVHLYNRDDLEKVLKYPSKYPFRPPTEII 142
            ..|......||   .::::.:.::  :.........||.:...:|.||:.:..|..|.|...|..
  Rat    54 ILREQSQENLH---LEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMTLESW 115

  Fly   143 VMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPALNAVCDDFIELLRARRDP 207
            |.:|:.|..|.   |:....|..|:..|..|..::.||:.:|:|:|.::.|..||:|.|:.|.
  Rat   116 VAHRELRGLRR---GVFLLNGADWRFNRLQLNPNMLSPKAVQSFVPFVDVVARDFVENLKKRM-- 175

  Fly   208 DTLVVPNFEELANLMG--------------LEAVCTLMLGRRMGFLAIDTKQPQKI-------SQ 251
                      |.|:.|              :||...::.|.|:|....|. .|:.:       |.
  Rat   176 ----------LENVHGSMSMDIQSNVFNYTMEASHFVISGERLGLTGHDL-NPESLKFIHALHSM 229

  Fly   252 LAAAVKQLFISQR-DSYYGLGLWK----------YFPTK----TYRDFARAEDLIYDVISEIIDH 301
            ..:..:.:|:.:. ..:....:||          .:.||    .||:.|......:.||||::
  Rat   230 FKSTTQLMFLPKNLTRWTSTQVWKGHFESWDIISEYVTKCIKNVYRELAEGRQQSWSVISEMV-- 292

  Fly   302 ELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTG 366
                        ......:.:|..|.:||               ||..::|.|.:|:..|..:..
  Rat   293 ------------AQSTLSMDAIHANSMEL---------------IAGSVDTTAISLVMTLFELAR 330

  Fly   367 DPGAMPRILSEFCEYRDTNIL---QDALTNATYTKACIQESYRLRPTAFCLARILEEDMELSGYS 428
            :|.....:..|... .:.:|.   |.|:::....:|.::|:.||.|....|.||::.|:.|..|.
  Rat   331 NPDVQQALRQESLA-AEASIAANPQKAMSDLPLLRAALKETLRLYPIGSSLERIVDSDLVLQNYH 394

  Fly   429 LNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPGKRF 493
            :.|||:|:..........:.|...:::.|:||:: ...:|.        .:.||.|.|.|.|:|.
  Rat   395 VPAGTLVIIYLYSMGRNPAVFPRPERYMPQRWLE-RKRSFQ--------HLAFGFGVRQCLGRRL 450

  Fly   494 VEMEVVLLLAKMVLAFDVSFVK--PLETEFEFLLAPKTPLSLRL 535
            .|:||:|||..|:..|.|..::  .::..:.|:|.|...|.|.:
  Rat   451 AEVEVLLLLHHMLKIFQVETLRQEDVQMAYRFVLMPNPRLVLTI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	114/515 (22%)
Cyp11b3	NP_861545.1	p450	41..494	CDD:278495	113/510 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820