DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	111/541 - (20%)
Similarity:	207/541 - (38%)	Gaps:	98/541 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVILLLALALVLGCYCALHRHKLADIYLRPLLKNTLLEDFYHAELIQPEAPKRRRRGIWDIPGP 65
            |.:|.|..::||:|...|:            |:.|   .|::            |:||   :|||
  Fly     1 MVLITLTLVSLVVGLLYAV------------LVWN---YDYW------------RKRG---VPGP 35

  Fly    66 KRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDI---------VLEVMPS---NVPIVHLY 118
            |.....| .:..:...:|:.:..|.::|.....:|..:         :|.:.|:   .|.:.:..
  Fly    36 KPKLLCG-NYPNMFTMKRHAIYDLDDIYRQYKNKYDAVGIFGSRSPQLLVINPALARRVFVSNFK 99

  Fly   119 NRDDLEKVLKYPSKYPF---RPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSP 180
            |..|.|.......|..|   ..|..:                    .|..|:..|:.:|..:|..
  Fly   100 NFHDNEIAKNIDEKTDFIFANNPFSL--------------------TGEKWKTRRADVTPGLTMG 144

  Fly   181 RVLQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQ 245
            |: :...|..|.||....|.:..:....:....:.:.::.....|.|...:||  :|..:...|.
  Fly   145 RI-KTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTDCVLG--LGAESFSDKP 206

  Fly   246 PQKISQLAAAVKQ-----LFISQRDSYYGLG---LWKYFPTKTYRDFARAEDLIYDVISEIIDHE 302
            ...:|::.....|     ||.....|:..|.   ..::.|....|.|.       |::...::..
  Fly   207 TPIMSKINDLFNQPWTFVLFFILTSSFPSLSHLIKLRFVPVDVERFFV-------DLMGSAVETR 264

  Fly   303 LEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGD 367
            ..:|   ||.:..|.:......|.:.|.::||.|...:..:.|:..|.||.|..|..:|.::..:
  Fly   265 RAQL---AAGKQFERSDFLDYILQLGEKRNLDNRQLLAYSMTFLLDGFETTATVLAHILLNLGRN 326

  Fly   368 PGAMPRILSEFCEY-RDTNILQDALTNATYTKACIQESYRLRPTAFCLARILEEDMEL-----SG 426
            ..|...:..|...: :|..|..:.|::..|..||:||:.||.|..|...::..|.:|:     ..
  Fly   327 KEAQNLLREEIRSHLQDGTIAFEKLSDLPYLDACVQETIRLFPPGFMSNKLCTESIEIPNKEGPN 391

  Fly   427 YSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDP-ATENFTVNVDNASIVVPFGVGRRSCPG 490
            :.:..||.|:..:......:..|...:.|.|||:::| |.:.|.    ...:.:.||.|.|.|.|
  Fly   392 FVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKTFR----ERGVFMGFGDGPRVCIG 452

  Fly   491 KRFVEMEVVLLLAKMVLAFDV 511
            .||..:::...:.:::..|:|
  Fly   453 MRFATVQIKAAIVELISKFNV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	98/479 (20%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	98/479 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910