Protein Alignment shd and CYP27C1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001354431.1
• Gene: CYP27C1 / 339761
• HGNCID: 33480
• Length: 537
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 124/501 - (24%)
• Similarity: 235/501 - (46%)
• Gaps: 37/501 - (7%)

  Fly    50 EAPKRRRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPI 114
            |.|    |.:..:|||:.:..|..      ||.|...:::||:.....|:||.|......... :
Human    61 EGP----RSLAAMPGPRTLANLAE------FFCRDGFSRIHEIQQKHTREYGKIFKSHFGPQF-V 114

  Fly   115 VHLYNRDDLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITS 179
            |.:.:||.:.:||:.....|.|...|   .:|:.|..|..:.|:::.:|..|.::||.|...|..
Human   115 VSIADRDMVAQVLRAEGAAPQRANME---SWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILK 176

  Fly   180 PRVLQNFLPALNAVCDDFIE---LLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAI 241
            |:.:..:...:|.|..|.|:   |||::.: |...|.|..:|.....:|.|.|::...|:|  .:
Human   177 PKDVAIYSGEVNQVIADLIKRIYLLRSQAE-DGETVTNVNDLFFKYSMEGVATILYESRLG--CL 238

  Fly   242 DTKQPQKISQLAAAVKQLFISQRDSYY--GLGLW-KYFPTKTYRDFARAEDLIYDVISEIIDHEL 303
            :...||...:...|::.:|...:.|.|  .:..| :.|..|.:|:|.|:.|.::......:|::|
Human   239 ENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKL 303

  Fly   304 EELKKSAACEDDEAAGLRS-IFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGD 367
            .:::.........:.||.: :||:    :.|.:::..:.:.:.:.||::|.:.||.:.:..:...
Human   304 RDIQYQMDRGRRVSGGLLTYLFLS----QALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARH 364

  Fly   368 PGAMPRILSEFCEYRDTNILQDA--LTNATYTKACIQESYRLRPTAFCLARILEEDMELSGYSLN 430
            |.....:..|..:......:..|  :......:|.::|:.||.|......|:.:||:.:.||.:.
Human   365 PEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIP 429

  Fly   431 AGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPGKRFVE 495
            .||.:...:....::|.||..||:|.||||:.....:   .|||.. .:|||.|.|||.|:|..|
Human   430 KGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLD---RVDNFG-SIPFGHGVRSCIGRRIAE 490

  Fly   496 MEVVLLLAKMVLAFDV---SFVKPLETEFEFLLAPKTPLSLRLSDR 538
            :|:.|::.:::..|::   |....:..:...||.|..|:.:|..:|
Human   491 LEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVNR 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	110/445 (25%)
CYP27C1	NP_001354431.1	CYP27C1	98..530	CDD:410740	110/446 (25%)