DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	112/537 - (20%)
Similarity:	200/537 - (37%)	Gaps:	131/537 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 RRRGIWDIPGPKRIPFLGTKWIFLLFFRR-----YKMTKLHEVYADLNRQYGDIVLEVMPSNVPI 114
            |:|||...|   ..||:|:   |...|.|     |.:..::|.|.|.:...|     |..:.||.
  Fly    30 RKRGIKTAP---TWPFVGS---FPSIFTRKRNIAYDIDDIYEKYKDTDNMVG-----VFTTRVPQ 83

  Fly   115 VHLYNRDDLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQ-------------GPMW 166
            :.:...:.:.|:  |.:.            :|....:.:.:  .||::             |..|
  Fly    84 LLVMCPEYIHKI--YATD------------FRSFHNNEWRN--FVNKKTDMILGNNPFVLTGDEW 132

  Fly   167 QRLRSSLTSSITSPRVLQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMGLEAV---- 227
            :..||.:..:: ||..::...|...:||..|:|.:|.:           :::|...||:|:
  Fly   133 KERRSEIMPAL-SPNRVKAVYPVSQSVCKKFVEYIRRQ-----------QQMATSEGLDAMDLSL 185

  Fly   228 ---------CTLMLGRRMGFLAIDTKQPQKISQLAAAVKQLF-ISQRDSYYGL--GLW----KYF 276
                     |.|.:..:.   ..||..|     |...:|::| .|....:|.:  .||    |::
  Fly   186 CYTTEVVSDCGLGVSAQS---FTDTPTP-----LLKMIKRVFNTSFEFIFYSVVTNLWQKVRKFY 242

  Fly   277 PTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSA 341
            ....:.  ...|....|:|...|...||:.::.   .||        |||.:    |.:::||..
  Fly   243 SVPFFN--KETEVFFLDIIRRCITLRLEKPEQQ---RDD--------FLNYM----LQLQEKKGL 290

  Fly   342 IID--------FIAAGIETLANTLLFVLSSVTGDPGAMPRILSEFCEYRDTNILQDALTNATYTK 398
            ..|        ||..|.||.|..|..::..:..:|....::..|.   ...::..|.::...:..
  Fly   291 HTDNILINTMTFILDGFETTALVLAHIMLMLGRNPEEQDKVRKEI---GSADLTFDQMSELPHLD 352

  Fly   399 ACIQESYRLRPTAFCLARILEEDMELSGYS-----LNAGTVVLCQNMIACHKDSNFQGAKQFTPE 458
            |||.|:.||........:::.|..|.:..:     |..|.||........|....::....|.||
  Fly   353 ACIYETLRLFSPQVAARKLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPE 417

  Fly   459 RWIDPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVSFVKPLETEFEF 523
            |::: :......:..:..:.:.||.|.|.|||.||...::...|.:::            ..||.
  Fly   418 RFLE-SNGGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEIL------------RNFEI 469

  Fly   524 LLAPKTPLSLRLSDRVF 540
            .:.|||....::.|..|
  Fly   470 KVNPKTRSDNQIDDTFF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	103/515 (20%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	104/516 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910