Protein Alignment shd and cyp27a1.4

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001315442.1
• Gene: cyp27a1.4 / 322341
• ZFINID: ZDB-GENE-030131-1060
• Length: 522
• Species: Danio rerio
• Alignment Length: 565
• Identity: 130/565 - (23%)
• Similarity: 248/565 - (43%)
• Gaps: 75/565 - (13%)

  Fly     1 MAVILLLALALVLGCYCALHRHKLADIYLRPLLKNTLLEDFYH------AELIQPEAPKRRRRGI 59
            |||...|:.|..|| :|          :|||   .|....|..      |..:..:...|:.:..
Zfish     1 MAVSFALSSAERLG-WC----------FLRP---TTAATGFRRAAGNSAAASVSVQDGHRKLKTE 51

  Fly    60 WDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLE 124
            .|:|..|....|     :.:.|:.| :..:||:.....:.||.: .::...|:..:.:.:.:.||
Zfish    52 ADLPEIKIFTML-----YQMLFKGY-LNSVHELQLYQKQVYGPL-WKINAGNLQGISITSVELLE 109

  Fly   125 KVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPA 189
            ::|:...|||.|   ..:.::.:.|..|..|.|...|:|..|.:||:.|...:..|:....:...
Zfish   110 ELLRKDEKYPCR---GYMTLWTEHRDLRGISYGPFTEEGEKWYKLRAVLNKRMLHPKDSLQYGDV 171

  Fly   190 LNAVCDDFIELLRARRD--PDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQKISQL 252
            :|||..|||:.:...|:  |...:|.|.........||.:.:::...|:|  .::.:.|.:..:.
Zfish   172 VNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLEGIASILFETRIG--CLEKEIPAETQEF 234

  Fly   253 AAAVKQLFISQRDSYYGLGL-----W--KYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSA 310
            ..::.|:|.      |.:.:     |  .|.|  .::.:....|.|:...:::|:.::|.: ::.
Zfish   235 INSIAQMFT------YNMHVALLPNWTRNYLP--FWQKYIDGWDGIFKFGTKMINLKMEAI-QTR 290

  Fly   311 ACEDDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMPRIL 375
            ...:.|.||....:|  |....:..:|...::.:.:.||::|.:||:|:.|..::.||.|...:.
Zfish   291 LDTNQEVAGEYLTYL--LSSGKMSCKDVYGSVSEVLLAGVDTTSNTMLWALYLLSKDPAAQETLH 353

  Fly   376 SEFCEYRDTNILQ-------DALTNATYTKACIQESYRLRPTAFCLARILEEDMELSG-YSLNAG 432
            .|.     |.:|:       :.:.:..:.||.|:|:.||.|.....:|::.|...:.| |.....
Zfish   354 QEV-----TKVLKGDRIPTAEEVNSMPFLKAVIKETLRLYPVVPVNSRLIAESEVIIGEYLFPKK 413

  Fly   433 TVVLCQNMIACHKDSNFQGAKQFTPERWI-DPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEM 496
            |.....:....|.:..|...::|.||||: |..|.      .|....:|||.|.|:|.|:|..|:
Zfish   414 TTFNLFHYAISHDEKVFPEPQKFKPERWLRDGRTR------PNPFGSIPFGFGVRACVGRRIAEL 472

  Fly   497 EVVLLLAKMVLAFDV---SFVKPLETEFEFLLAPKTPLSLRLSDR 538
            |:.|.||:::..|::   ..|..::..|..:|.|...::|...:|
Zfish   473 EMHLALARLIKLFEMRPDPTVGEVKANFRSVLVPNKKVNLHFVER 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	105/454 (23%)
cyp27a1.4	NP_001315442.1	CYP27A1	83..512	CDD:410739	105/456 (23%)