Protein Alignment shd and Cyp27a1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_849178.2
• Gene: Cyp27a1 / 301517
• RGDID: 727915
• Length: 533
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 141/520 - (27%)
• Similarity: 232/520 - (44%)
• Gaps: 78/520 - (15%)

  Fly    55 RRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYN 119
            |.|.:.::|||..:.||     |.||.|.| :..|||:.|....:||.:......:... |:|.:
  Rat    55 RLRSLAELPGPGTLRFL-----FQLFLRGY-VLHLHELQALNKAKYGPMWTTTFGTRTN-VNLAS 112

  Fly   120 RDDLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQ 184
            ...||:|::...|||.|...|   .:::.|..:..|.||...||..|..||.||...:..|....
  Rat   113 APLLEQVMRQEGKYPIRDSME---QWKEHRDHKGLSYGIFITQGQQWYHLRHSLNQRMLKPAEAA 174

  Fly   185 NFLPALNAVCDDFIELLRARRDPDTL--VVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQ 247
            .:..|||.|..|||..|...|.....  .||:...|...:.|||:|.::..:|:|.|     :|.
  Rat   175 LYTDALNEVISDFIARLDQVRTESASGDQVPDVAHLLYHLALEAICYILFEKRVGCL-----EPS 234

  Fly   248 KISQLAAAVKQLFISQRDSYYG----------LGLWKYFPTKTYRDFARAEDLIYDVISEIIDHE 302
            .....|..::.:.:..::|.|.          |..||.:.......|:..|.:|:..:.||
  Rat   235 IPEDTATFIRSVGLMFKNSVYVTFLPKWSRPLLPFWKRYMNNWDNIFSFGEKMIHQKVQEI---- 295

  Fly   303 LEELKKSAACEDDEAAGLR-SIFLNILELKD-LDIRDKKSAIIDFIAAGIETLANTLLFVLSSVT 365
              |.:..||..|    |:: |.:|:.|..|: |..::......:.|.||::|.:|||.:.|..::
  Rat   296 --EAQLQAAGPD----GVQVSGYLHFLLTKELLSPQETVGTFPELILAGVDTTSNTLTWALYHLS 354

  Fly   366 GDP-----------GAMPRILSEFCEYRDTNILQDALTNATYTKACIQESYRLRPTAFCLARIL- 418
            .:|           |.:|  ..:..:.:|       ..:....||.|:|:.||.|.....:||:
  Rat   355 KNPEIQEALHKEVTGVVP--FGKVPQNKD-------FAHMPLLKAVIKETLRLYPVVPTNSRIIT 410

  Fly   419 EEDMELSGYSLNAGT-VVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASI----- 477
            |::.|::|:.....| .|||..::: ...|.|...:.|.|.||:....:      ||:.|
  Rat   411 EKETEINGFLFPKNTQFVLCHYVVS-RDPSVFPEPESFQPHRWLRKRED------DNSGIQHPFG 468

  Fly   478 VVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVSFVKP----LETEFEFLLAPKTPLSLRLSDR 538
            .||||.|.|||.|:|..|:|:.|||::::..::| .:.|    :::....:|.|...:|||...|
  Rat   469 SVPFGYGVRSCLGRRIAELEMQLLLSRLIQKYEV-VLSPGMGEVKSVSRIVLVPSKKVSLRFLQR 532

  Fly   539  538
              Rat   533  532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	121/469 (26%)
Cyp27a1	NP_849178.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..58		1/2 (50%)
		cytochrome_P450	91..527	CDD:477761	121/471 (26%)
		Sterol-binding. /evidence=ECO:0000255	386..400		6/13 (46%)