Protein Alignment shd and CYP4V2

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 108/476 - (22%)
• Similarity: 195/476 - (40%)
• Gaps: 85/476 - (17%)

  Fly   104 VLEVMPSNVPIVHLYNRDDLE------KVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQ 162
            :|::....||:|.|||.:::|      |.:...|.|.|..|              :..:|::...
Human    89 LLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEP--------------WLGLGLLTST 139

  Fly   163 GPMWQRLRSSLTSSITSPRVLQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMGLEAV 227
            |..|:..|..||.:... .:|::||..:|...:..::.|....:.:..   |......|..|:.:
Human   140 GNKWRSRRKMLTPTFHF-TILEDFLDIMNEQANILVKKLEKHINQEAF---NCFFYITLCALDII 200

  Fly   228 CTLMLGRRMGFLAIDTKQPQKISQLAAAV----KQLFISQRDSYYGLGLWKYFPTKTYRDFARAE 288
            |...:|:.:|      .|....|:...||    :.:|...:..:..|.|| |...|...:..::.
Human   201 CETAMGKNIG------AQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLW-YLMFKEGWEHKKSL 258

  Fly   289 DLIYDVISEIIDHELEELKKSAACEDD-----EAAGLRSIFLNIL---------ELKDLDIRDKK 339
            .:::...:.:|.....|:..:..|..|     .:...|..||::|         .|...|||::
Human   259 QILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREE- 322

  Fly   340 SAIIDFIAAGIETLA---NTLLFVLSSVTGDPGAMPRI---LSEFCEYRDTNILQDALTNATYTK 398
              :..|:..|.:|.|   |..|::|.|   :|....::   |.:.....|.....:.|....|.:
Human   323 --VDTFMFEGHDTTAAAINWSLYLLGS---NPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLE 382

  Fly   399 ACIQESYRLRPTAFCLARILEEDMELSGYSLNAGT--VVLCQNMIACHKDSN-FQGAKQFTPERW 460
            ..|:|:.||.|:....||.:.||.|::||.:..||  |::   ..|.|:|.. |...::|.|||:
Human   383 CVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVII---PYALHRDPRYFPNPEEFQPERF 444

  Fly   461 IDPATENFTVNVDNAS-----IVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVSFVKPLE-- 518
            ..          :||.     ..|||..|.|:|.|::|..||...:|:.::..|.:...:..|
Human   445 FP----------ENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREEL 499

  Fly   519 -TEFEFLLAPKTPLSLRLSDR 538
             .|.:.:|.|...:.::|..|
Human   500 GLEGQLILRPSNGIWIKLKRR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	106/468 (23%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	106/469 (23%)