Protein Alignment shd and Cyp24a1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_963966.1
• Gene: Cyp24a1 / 25279
• RGDID: 2462
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 570
• Identity: 139/570 - (24%)
• Similarity: 244/570 - (42%)
• Gaps: 106/570 - (18%)

  Fly    17 CALHRHKLADIYLRPLLKNTLLEDFYHAELIQP-----------EAPKR----------RRRGIW 60
            |.:.:.:....:||.|           .:|.||           .|||.          ..|.:.
  Rat     3 CPIDKRRTLIAFLRRL-----------RDLGQPPRSVTSKASASRAPKEVPLCPLMTDGETRNVT 56

  Fly    61 DIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEK 125
            .:|||...|.||:   .|..|.:..:.|.|:..|:.:::||.| ..:...:...|||.:...||.
  Rat    57 SLPGPTNWPLLGS---LLEIFWKGGLKKQHDTLAEYHKKYGQI-FRMKLGSFDSVHLGSPSLLEA 117

  Fly   126 VLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSP---------- 180
            :.:..|.:|.|...:....||..|.:.|   |::..:|..|||:||:....:..|
  Rat   118 LYRTESAHPQRLEIKPWKAYRDHRNEAY---GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKI 179

  Fly   181 -RVLQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTK 244
             .||.:||..::.:||:     |.|       :|:.....|....|::|.::..:|.|.|..:|:
  Rat   180 NEVLADFLERMDELCDE-----RGR-------IPDLYSELNKWSFESICLVLYEKRFGLLQKETE 232

  Fly   245 QPQKISQLAAAVKQLFISQRDSYYG------LGLWKYFPTKTYRDFARAEDLIYDVISEIIDHEL 303
              ::......|:|.:.     |.:|      :.|.|...||.::....|.|.|:..:...||:.|
  Rat   233 --EEALTFITAIKTMM-----STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRL 290

  Fly   304 EELKKSAACEDDEAAGLRSIFL-NILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGD 367
            :...:....:          || :|.:...|..::..:|:.:...|.:||.||:|:::|.:::.:
  Rat   291 QRYSQQPGAD----------FLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345

  Fly   368 PGAMPRILSEFCEYRDTNILQD-------ALTNATYTKACIQESYRLRPTAFCLARILEEDMELS 425
            |.|..|:|.|.     .::|.|       .|.|..|.|||::||.||.|:.....|.|::...|.
  Rat   346 PQAQRRLLQEV-----QSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLG 405

  Fly   426 GYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPG 490
            .|:|..|||:.....:....:.||:.:.:|.||||:....:      .|....:|||:|:|.|.|
  Rat   406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK------INPFAHLPFGIGKRMCIG 464

  Fly   491 KRFVEMEVVLLLAKMVLAFDVSFV--KPLETEFEFLLAPKTPLSLRLSDR 538
            :|..|:::.|.|..::..:|:...  :|:|.....:|.|...|.:....|
  Rat   465 RRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	115/460 (25%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	115/461 (25%)