Protein Alignment shd and cyp-25A4

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_497779.1
• Gene: cyp-25A4 / 183248
• WormBaseID: WBGene00007967
• Length: 501
• Species: Caenorhabditis elegans
• Alignment Length: 549
• Identity: 113/549 - (20%)
• Similarity: 215/549 - (39%)
• Gaps: 134/549 - (24%)

  Fly    55 RRRGIW------DIPGP-------------KRIPFLG----TKWIFLLFFRRYKMTKLHEVYADL 96
            ||..|:      .||||             .|:..||    |:|                 :..|
 Worm    23 RRHAIFKLRSSIGIPGPPVHWLWGNLNIIKDRVSRLGYNDTTQW-----------------HPTL 70

  Fly    97 NRQYGDIVLEVMPSNVPIVHLY----------NRDDLEKV-LKYPSKYPFRPPTEIIVMYRQSRP 150
            :.:||           ||..||          ..:|:::: ::..|.:..|...:|..|.:.::
 Worm    71 HTKYG-----------PIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPDIFGMNQLNQ- 123

  Fly   151 DRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPALNAVCDDFIELLRARRDPDTL--VVP 213
                |: :.|.....|:..||:: :.|.|...::.....|.:..|.|:|:|:.:......  :..
 Worm   124 ----SL-LQNTYATGWKHTRSAI-APIFSTGKMKAMHETLVSKIDIFLEVLKEKSSSGQKWDIFE 182

  Fly   214 NFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQKISQLAAAVKQLFISQRD------------- 265
            ||:.|:  :.:...|.         .|||:...:..:.|.....:.|:...|
 Worm   183 NFQSLS--LDIIGKCA---------FAIDSNCQRDRTDLFYVQARKFVGAVDLKKSWILPVSLIL 236

  Fly   266 ---SYYGLGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACEDDEAAGLRSIFLNI 327
               |:    ||::.  ..:.|.:.||   ..::..::|  |.:.:::....:|.     :..||:
 Worm   237 PELSW----LWRFL--YKFSDLSAAE---LPLVKGLVD--LYDRRRAGEGGNDS-----TDLLNL 285

  Fly   328 LELKDLDIRDKKSAIID----FIAAGIETLANTLLFVLSSVTGDPGAMPRILSEFCEYRD-TNIL 387
            |..::...:..:..:|:    |:.||.||.:..::|....:...|....::..|..:.:: ..:.
 Worm   286 LIRRETIGKMTQREVIENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKTKENAGLN 350

  Fly   388 QDALTNATYTKACIQESYRL-RPTAFCLARILEEDMELSGYSLNAGTVVLCQNMIACHKDSNFQG 451
            .|::.|..|.....:||.|. .||.....|:...||.:.|......:.:..|........:|::.
 Worm   351 YDSIHNMKYLDCVYKESLRFYPPTTHFTNRVCLNDMTIRGQIYPEDSTLKVQPYTIHRNPANWES 415

  Fly   452 AKQFTPERWIDPATENFTVNVDNASIV--VPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVSFV 514
            ..:|.|||:     ||:.   :.:|.:  :|||||.|.|.|.||.|||....:||::..|::|.|
 Worm   416 PDEFQPERF-----ENWE---EKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELSLV 472

  Fly   515 ---KPLETEFE-FLLAPKTPLSLRLSDRV 539
               .|:..|.. .:..|::|:.|.|..|:
 Worm   473 PGDPPMIPETNGVIFRPRSPVRLNLKLRI 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	97/474 (20%)
cyp-25A4	NP_497779.1	CYP3A-like	73..494	CDD:410678	97/473 (21%)