Protein Alignment shd and cyp-25A1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_497775.3
• Gene: cyp-25A1 / 183247
• WormBaseID: WBGene00007963
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 126/583 - (21%)
• Similarity: 228/583 - (39%)
• Gaps: 127/583 - (21%)

  Fly     1 MAVILLLALALVLGCYCALHRHKLADIYLRPLLKNTLLEDFYHAELIQPEAPKRRRRGIWDIPGP 65
            ||:::|.:|.:                        ::...|.:..|.:.|..|.|.:  ..:.||
 Worm     1 MALLILSSLVI------------------------SIFTFFIYIILARRERFKLREK--IGLSGP 39

  Fly    66 KRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNR-------QYGDIVLEVMPSNVPIVHLYNRDDL 123
            :...|||.       .::....|....|.|.||       |||:.......|.:.|| :.|..|:
 Worm    40 EPHWFLGN-------LKQTAERKEKLGYDDANRWFNELHEQYGETFGIYYGSQMNIV-ISNEKDI 96

  Fly   124 EKV-LKYPSKYPFRPPTEIIVMYRQSRPDRY------ASVGIVNEQGPMWQRLRSSLTSSITSPR 181
            ::| :|..|.:..|           |.|..|      ||: ::|.....|:..||:: :.|.|..
 Worm    97 KEVFIKNFSNFSDR-----------SVPSIYEANQLTASL-LMNSYSSGWKHTRSAI-APIFSTG 148

  Fly   182 VLQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQP 246
            .::.....:|:..|.|:::||.:....    ..::...:..||    ||.:..:..| |||:...
 Worm   149 KMKAMQETINSKVDLFLDILREKASSG----QKWDIYDDFQGL----TLDVIGKCAF-AIDSNCQ 204

  Fly   247 QKISQLAAAVKQLFISQRD----------------SYYGLGLWKYFPTKTYRDFARAEDLIYDVI 295
            :..:.:.....:.:||..|                |.:...|:||.|      .|.||..:.:.:
 Worm   205 RDRNDVFYVNAKKYISNIDIRHSKIIAASVLLPELSTFWKALYKYTP------LADAEIPLVEGL 263

  Fly   296 SEIIDHELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAIID----FIAAGIETLANT 356
            |.:.:       :....|..::..|..:.||..:.|...:  .|..:|:    |:.||.||.:..
 Worm   264 SNVYE-------RRRGGEGSDSVDLLKLLLNREDDKSKPM--TKQEVIENCFAFLLAGYETTSTA 319

  Fly   357 LLFVLSSVTGDPGAMPRILSEFCEYRDT-NILQDALTNATYTKACIQESYRLRPTAF-CLARILE 419
            :.:....::..|....::..|..|.::. .:..|::.|..|.....:|:.|..|... .:.|:..
 Worm   320 MTYCSYLLSKYPNVQQKLYEEIMEAKENGGLTYDSIHNMKYLDCVYKETLRFYPPVIHFIRRLCR 384

  Fly   420 EDMELSGYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIV--VPFG 482
            ||:.:.|.....|.:|:|..........|:...::|.|||:     ||:.   :.:|.:  :|||
 Worm   385 EDITIRGQFYPKGAIVVCLPHTVHRNPENWDSPEEFHPERF-----ENWE---EKSSSLKWIPFG 441

  Fly   483 VGRRSCPGKRFVEMEVVLLLAKMVLAFDVSFVKPLETEFEF-------LLAPKTPLSLRLSDR 538
            ||.|.|.|.||.|||....:.|::..|:   :|..|.|.:.       ::.|..|:.|.|..|
 Worm   442 VGPRYCVGMRFAEMEFKTTIVKLLDTFE---LKQFEGEADLIPDCNGVIMRPNDPVRLHLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	105/478 (22%)
cyp-25A1	NP_497775.3	CYP3A-like	73..495	CDD:410678	104/470 (22%)