DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and CYP27B1

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_000776.1	Gene:	CYP27B1 / 1594	HGNCID:	2606	Length:	508	Species:	Homo sapiens

Alignment Length:	537	Identity:	131/537 - (24%)
Similarity:	222/537 - (41%)	Gaps:	98/537 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YHAELIQPEAPKRRRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLE 106
            ||:          .||.:.|||||....||..      .|.:..:::|||:.......:|.:.|.
Human    30 YHS----------ARRSLADIPGPSTPSFLAE------LFCKGGLSRLHELQVQGAAHFGPVWLA 78

  Fly   107 VMPSNVPIVHLYNRDDLEKVLKY----PSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQ 167
            .. ..|..|::.....:|::|:.    |.:..|.|.||       .|..|..:.|::..:|..||
Human    79 SF-GTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTE-------HRRCRQRACGLLTAEGEEWQ 135

  Fly   168 RLRSSLTSSITSPRVLQNFLPALNAVCDDFIELLRARR----DPDTLVVPNFEELAN---LMGLE 225
            ||||.|...:..|:....:...||.|..|.:..||.:|    .|..||    .::|.   ..|||
Human   136 RLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALV----RDVAGEFYKFGLE 196

  Fly   226 AVCTLMLGRRMGFLAIDTKQPQKISQLAAAVKQLFISQRDS--------YYGLGLWKYFPTKTYR 282
            .:..::||.|:|  .::.:.|........||..:|:|...:        :...|.|    .:..|
Human   197 GIAAVLLGSRLG--CLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPW----GRLCR 255

  Fly   283 DFARAEDLIYDVISEIIDHELEELKKSAAC------EDDEAAGLRSIFLNILELKDLDIRDKKSA 341
            |        :|.:.......:|..:..||.      |.|..:|..  ..:.|..::|..:.....
Human   256 D--------WDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAH--LTHFLFREELPAQSILGN 310

  Fly   342 IIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEF--------CEYRDTNILQDALTNATYTK 398
            :.:.:.||::|::|||.:.|..::..|.....:.||.        ..|....:    |:.....|
Human   311 VTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATV----LSQLPLLK 371

  Fly   399 ACIQESYRLRPTAFCLARILEEDMELSGYSLNAGTVV-LCQNMIACHKD-SNFQGAKQFTPERWI 461
            |.::|..||.|.....:|:.::|:.:..|.:...|:| ||.  .|..:| :.|.....|.|.||:
Human   372 AVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCH--YATSRDPAQFPEPNSFRPARWL 434

  Fly   462 --DPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVS---FVKPLETEF 521
              .|....|      ||:  |||.|:|||.|:|..|:|:.:.||:::..|:|.   ...|:..:.
Human   435 GEGPTPHPF------ASL--PFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKT 491

  Fly   522 EFLLAPKTPLSLRLSDR 538
            ..:|.|:..::|:..||
Human   492 RTVLVPERSINLQFLDR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	121/504 (24%)
CYP27B1	NP_000776.1	p450	41..505	CDD:278495	123/511 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820