DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and CYP27A1

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_000775.1	Gene:	CYP27A1 / 1593	HGNCID:	2605	Length:	531	Species:	Homo sapiens

Alignment Length:	505	Identity:	124/505 - (24%)
Similarity:	230/505 - (45%)	Gaps:	78/505 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 KRRRRGIWDIPGPKRIPFLG-TKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVH 116
            :||:|.:      :.||.|| .::.|.||.:.|.: :||::......:||.:.:..:...:. |:
Human    51 RRRQRSL------EEIPRLGQLRFFFQLFVQGYAL-QLHQLQVLYKAKYGPMWMSYLGPQMH-VN 107

  Fly   117 LYNRDDLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPR 181
            |.:...||:|::...|||.|...|   ::::.|.....:.|....:|..|.:||.:|...:..|.
Human   108 LASAPLLEQVMRQEGKYPVRNDME---LWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPA 169

  Fly   182 VLQNFLPALNAVCDDF---IELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDT 243
            ....:..|.|.|.|||   ::.|||...... .|.:..:|.....|||:|.::..:|:|  .:..
Human   170 EAALYTDAFNEVIDDFMTRLDQLRAESASGN-QVSDMAQLFYYFALEAICYILFEKRIG--CLQR 231

  Fly   244 KQPQKISQLAAAVKQLFISQRDSYYGLGLWKY----FP-TKTYRDFARAEDLIYDVISEIIDHEL 303
            ..|:.......::..:|   ::|.|...|.|:    .| .|.|.|...|   |:....::||.:|
Human   232 SIPEDTVTFVRSIGLMF---QNSLYATFLPKWTRPVLPFWKRYLDGWNA---IFSFGKKLIDEKL 290

  Fly   304 EELKKSAACEDDEAAGLRSIFLN-----ILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSS 363
            |:::...     :|||...|.::     :|....|..|:...::.:.:.||::|.:|||.:.|..
Human   291 EDMEAQL-----QAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYH 350

  Fly   364 VTGDP-----------GAMPRILSEFCEYRDTNILQDALTNATYTKACIQESYRLRPTAFCLARI 417
            ::.||           |.:|  ..:..:::|       ..:....||.::|:.||.|.....:||
Human   351 LSKDPEIQEALHEEVVGVVP--AGQVPQHKD-------FAHMPLLKAVLKETLRLYPVVPTNSRI 406

  Fly   418 LEEDMELSGYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWI---DPATENFTVNVDNASIVV 479
            :|:::|:.|:.....|..:..:.:.....:.|...:.|.|.||:   .|||.    .:.:....|
Human   407 IEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATP----RIQHPFGSV 467

  Fly   480 PFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVSFVKPLETEFEFLLAPKT 529
            |||.|.|:|.|:|..|:|:.||||:::            .:::.:|||:|
Human   468 PFGYGVRACLGRRIAELEMQLLLARLI------------QKYKVVLAPET 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	119/492 (24%)
CYP27A1	NP_000775.1	p450	61..526	CDD:306555	120/489 (25%)
CYP27A1	NP_000775.1	Sterol-binding. /evidence=ECO:0000255	384..398		5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820