Protein Alignment shd and CYP24A1

DIOPT Version :9

• Sequence 1: NP_001261843.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 129/499 - (25%)
• Similarity: 222/499 - (44%)
• Gaps: 64/499 - (12%)

  Fly    62 IPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEKV 126
            :|||...|.||:   .|....:..:.|.|:...:.:::||.| ..:...:...|||.:...||.:
Human    58 LPGPTSWPLLGS---LLQILWKGGLKKQHDTLVEYHKKYGKI-FRMKLGSFESVHLGSPCLLEAL 118

  Fly   127 LKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSP----------- 180
            .:..|.||.|...:....||..|.:.|   |::..:|..|||:||:....:..|
Human   119 YRTESAYPQRLEIKPWKAYRDYRKEGY---GLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180

  Fly   181 RVLQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQ 245
            .||.:|:..::.:||:       |...:.|    :.|| |....|::|.::..:|.|.|  ....
Human   181 EVLADFMGRIDELCDE-------RGHVEDL----YSEL-NKWSFESICLVLYEKRFGLL--QKNA 231

  Fly   246 PQKISQLAAAVKQLFISQRDSYYG------LGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELE 304
            ..:......|:|.:.     |.:|      :.|.|...||.::|...|.|.|:..:...||:.||
Human   232 GDEAVNFIMAIKTMM-----STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLE 291

  Fly   305 ELKKSAACEDDEAAGLRSIFL-NILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDP 368
            :..:..:.:          || :|.....|..::..:|:.:...|.:||.||:|:::|.:::.:|
Human   292 KYSQQPSAD----------FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346

  Fly   369 GAMPRILSEFCEYRDTNILQDA--LTNATYTKACIQESYRLRPTAFCLARILEEDMELSGYSLNA 431
            ....::|.|.......|.:..|  |.|..|.|||::||.||.|:.....|.|::...|..|:|..
Human   347 QVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPK 411

  Fly   432 GTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEM 496
            |||::....:....:.||:.:.||.||||:....:      .|....:|||||:|.|.|:|..|:
Human   412 GTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEK------INPFAHLPFGVGKRMCIGRRLAEL 470

  Fly   497 EVVLLLAKMVLAFDVSFV--KPLETEFEFLLAPKTPLSLRLSDR 538
            ::.|.|..:|..:|:...  :|:|......|.|...|.:....|
Human   471 QLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	126/486 (26%)
CYP24A1	NP_000773.2	p450	59..512	CDD:278495	128/494 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4812
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770