Protein Alignment shd and CYP11A1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_000772.2
• Gene: CYP11A1 / 1583
• HGNCID: 2590
• Length: 521
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 128/514 - (24%)
• Similarity: 213/514 - (41%)
• Gaps: 83/514 - (16%)

  Fly    54 RRRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMT-KLHEVYADLNRQYGDIVLEVMPSNVPIVHL 117
            |..|...:||.|.     ...|:.|..|.|...| |:|..:....::||.|..|.: .||..|::
Human    43 RSPRPFNEIPSPG-----DNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKL-GNVESVYV 101

  Fly   118 YNRDDLEKVLKYPSKYPFR---PPTEIIVMYRQ--SRPDRYASVGIVNEQGPMWQRLRSSLTSSI 177
            .:.:|:..:.|.....|.|   ||.   |.|.|  .||     :|::.::...|::.|.:|...:
Human   102 IDPEDVALLFKSEGPNPERFLIPPW---VAYHQYYQRP-----IGVLLKKSAAWKKDRVALNQEV 158

  Fly   178 TSPRVLQNFLPALNAVCDDFIELLRARRD-----------PDTLVVPNFEELANLMGLEAVCTLM 231
            .:|...:||||.|:||..||:.:|..|..           .|.|....||.:.|         ::
Human   159 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITN---------VI 214

  Fly   232 LGRRMGFLAIDTKQPQKISQLAAAVKQLFISQRDSYYGL------------GLWKYFPTKTYRDF 284
            .|.|.|.|. :...|:         .|.||   |:.|.:            .|::.|.|||::|.
Human   215 FGERQGMLE-EVVNPE---------AQRFI---DAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDH 266

  Fly   285 ARAEDLIYDVISEIIDHELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAG 349
            ..|.|:|:........:...||::..:...|    .|.|...:|....:...|.|:.:.:.:|.|
Human   267 VAAWDVIFSKADIYTQNFYWELRQKGSVHHD----YRGILYRLLGDSKMSFEDIKANVTEMLAGG 327

  Fly   350 IETLANTLLFVLSSVTGDPGAMPRILSEF--CEYRDTNILQDALTNATYTKACIQESYRLRPTAF 412
            ::|.:.||.:.|..:..:......:.:|.  ..::....:...|......||.|:|:.||.|.:.
Human   328 VDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV 392

  Fly   413 CLARILEEDMELSGYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTV--NVDNA 475
            .|.|.|..|:.|..|.:.|.|:|.........:.:.|...:.|.|.||:. ..:|.|.  |:.
Human   393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLS-KDKNITYFRNLG-- 454

  Fly   476 SIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAF--DVSFVKPLETEFEFLLAPKTPLS 532
                 ||.|.|.|.|:|..|:|:.:.|..|:..|  ::..:..:.|.|..:|.|:.|:|
Human   455 -----FGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPIS 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	115/467 (25%)
CYP11A1	NP_000772.2	CYP11A1	82..508	CDD:410736	115/468 (25%)