Protein Alignment shd and Cyp27b1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_034139.2
• Gene: Cyp27b1 / 13115
• MGIID: 1098274
• Length: 507
• Species: Mus musculus
• Alignment Length: 529
• Identity: 130/529 - (24%)
• Similarity: 220/529 - (41%)
• Gaps: 103/529 - (19%)

  Fly    57 RGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRD 121
            |.:.|||||..:.||..      .|.:..:::|||:......:||.|..... ..:..|::.:..
Mouse    35 RSLSDIPGPSTLSFLAE------LFCKGGLSRLHELQVHGAARYGPIWSGSF-GTLRTVYVADPT 92

  Fly   122 DLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNF 186
            .:|::|:..|..|.|..   ...:.:.|.....:.|::...|..||||||.|...:..|:....:
Mouse    93 LVEQLLRQESHCPERCS---FSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGY 154

  Fly   187 LPALNAVCDDFIELLRARRDPDT----LVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQ 247
            ...|:.|..|.:..||.:|...:    ||:....|... .|||::..::||.|:|  .::.:.|.
Mouse   155 AGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYK-FGLESIGAVLLGSRLG--CLEAEVPP 216

  Fly   248 KISQLAAAVKQLFIS------QRDSYYGL--GLWKYFPTKTYRD----FARAEDLIYDVISEIID 300
            .......||..:|:|      ..:..:.|  |.|    .:..||    ||.|:..:
Mouse   217 DTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPW----ARLCRDWDQMFAFAQRHV--------- 268

  Fly   301 HELEE----LKKSAACEDD-------------EAAGLRSIFLNILELKDLDIRDKKSAIIDFIAA 348
             ||.|    ::.....|:|             |...::||..|:.||               :.|
Mouse   269 -ELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTEL---------------LLA 317

  Fly   349 GIETLANTLLFVLSSVTGDPGAMPRILSEF-------CEYRDTNILQDALTNATYTKACIQESYR 406
            |::|::|||.:.|..::..|.....:.||.       |.:....    ||:.....||.|:|..|
Mouse   318 GVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGT----ALSQLPLLKAVIKEVLR 378

  Fly   407 LRPTAFCLARILEEDMELSGYSLNAGTVV-LCQNMIACHKD-SNFQGAKQFTPERWI--DPATEN 467
            |.|.....:|:.:.|:.:..|.:...|:| ||.  .|..:| :.|.....|.|.||:  .|....
Mouse   379 LYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCH--YATSRDPTQFPDPNSFNPARWLGEGPTPHP 441

  Fly   468 FTVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDV---SFVKPLETEFEFLLAPKT 529
            |      ||:  |||.|:|||.|:|..|:|:.:.|::::..|:|   ....|::.....:|.|:.
Mouse   442 F------ASL--PFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPER 498

  Fly   530 PLSLRLSDR 538
            .::|:..||
Mouse   499 SINLQFVDR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	115/480 (24%)
Cyp27b1	NP_034139.2	CYP27B1	68..502	CDD:410741	115/483 (24%)