DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and Cyp11b2

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_034121.4	Gene:	Cyp11b2 / 13072	MGIID:	88584	Length:	500	Species:	Mus musculus

Alignment Length:	490	Identity:	117/490 - (23%)
Similarity:	211/490 - (43%)	Gaps:	56/490 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PKRI-PFLG------TKWIFLL-FFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRD 121
            ||.: ||..      .||:.:: ..|......||.....:.|:.|.|....: ....||.:...:
Mouse    32 PKTLQPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHSV-GKTQIVSVMLPE 95

  Fly   122 DLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNF 186
            |.||:.:..|..|.|...|..|.:|:.|..|.   |:....||.|:..|..|..::.||:.:|.|
Mouse    96 DAEKLHQVESMLPRRMHLEPWVAHRELRGLRR---GVFLLNGPEWRLNRLRLNRNVLSPKAVQKF 157

  Fly   187 LPALNAVCDDFIELLRAR-----RDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQP 246
            :|.::.|..||:|.|:.:     |...|:.|.  :.|.|.. :||....:.|.|:|.|..|. .|
Mouse   158 VPMVDMVARDFLETLKEKVLQNARGSLTMDVQ--QSLFNYT-IEASNFALFGERLGLLGHDL-SP 218

  Fly   247 QKI-------SQLAAAVKQLFISQRDSYYGLGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELE 304
            ..:       |...:..:.||:.:       .|.::..|:.:::...|.|:|.:..:..|....:
Mouse   219 GSLKFIHALHSMFKSTSQLLFLPK-------SLTRWTSTRVWKEHFDAWDVISEYANRCIWKVHQ 276

  Fly   305 ELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPG 369
            ||:..:      :.....|...::....|.:...|:..::..|..::|.|..|:..|..:..:|.
Mouse   277 ELRLGS------SQTYSGIVAELISQGSLPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPD 335

  Fly   370 AMPRILSEFCEYRDTNIL---QDALTNATYTKACIQESYRLRPTAFCLARILEEDMELSGYSLNA 431
            ....:..|... .:.:|.   |.|:::....:|.::|:.||.|....|.|||..|:.|..|.:.|
Mouse   336 VQKALRQESLA-AEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILSSDLVLQNYHVPA 399

  Fly   432 GTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEM 496
            ||:||..........:.|...:::.|:||:: ...:|.        .:.||.|.|.|.|:|..|:
Mouse   400 GTLVLLYLYSMGRNPAVFPRPERYMPQRWLE-RKRSFQ--------HLAFGFGVRQCLGRRLAEV 455

  Fly   497 EVVLLLAKMVLAFDVSFVK--PLETEFEFLLAPKT 529
            |::|||..::..|.|..::  .::..:.|:|.|.:
Mouse   456 EMMLLLHHILKTFQVETLRQEDVQMAYRFVLMPSS 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	116/487 (24%)
Cyp11b2	NP_034121.4	p450	42..496	CDD:365848	113/480 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920