Protein Alignment shd and Cyp27b1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_446215.1
• Gene: Cyp27b1 / 114700
• RGDID: 69192
• Length: 501
• Species: Rattus norvegicus
• Alignment Length: 529
• Identity: 134/529 - (25%)
• Similarity: 223/529 - (42%)
• Gaps: 102/529 - (19%)

  Fly    57 RGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRD 121
            |.:.|||||....||..      .|.:..:::|||:......:||.|..... ..:..|::.:..
  Rat    28 RSLSDIPGPSTPSFLAE------LFCKGGLSRLHELQVHGAARYGPIWSGSF-GTLRTVYVADPA 85

  Fly   122 DLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNF 186
            .:|::|:..|..|.|..   ...:.:.|.....:.|::...|..||||||.|...:..|:....:
  Rat    86 LVEQLLRQESHCPERCS---FSSWSEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGY 147

  Fly   187 LPALNAVCDDFIELLRARRD-----PDTL--VVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTK 244
            ...|::|..|.:..||.:|.     ||.:  |...|.:    .|||.:..::||.|:|  .::.:
  Rat   148 AGTLDSVVSDLVRRLRRQRGRGSGLPDLVLDVAGEFYK----FGLEGIGAVLLGSRLG--CLEAE 206

  Fly   245 QPQKISQLAAAVKQLFISQRDSYYGLGLWKYFPTKTYR----DFAR-AEDLIYDVISEIIDHELE 304
            .|........||..:|:|..       |....|:..:|    .:|| ..|  :|.:.......:|
  Rat   207 VPPDTETFIEAVGSVFVSTL-------LTMAMPSWLHRLIPGPWARLCRD--WDQMFAFAQKHVE 262

  Fly   305 ELKKSAAC------EDD-------------EAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGI 350
            :.:..||.      |:|             |...::||..|:.||               :.||:
  Rat   263 QREGEAAVRNQGKPEEDLPTGHHLTHFLFREKVSVQSIVGNVTEL---------------LLAGV 312

  Fly   351 ETLANTLLFVLSSVTGDPGAMPRILSEFC------EYRDTNILQDALTNATYTKACIQESYRLRP 409
            :|::|||.:.|..::..|.....:.||..      .|  .::...||:.....||.|:|..||.|
  Rat   313 DTVSNTLSWALYELSRHPEVQSALHSEITGAVNPGSY--AHLQATALSQLPLLKAVIKEVLRLYP 375

  Fly   410 TAFCLARILEEDMELSGYSLNAGTVV-LCQNMIACHKD-SNFQGAKQFTPERWI--DPATENFTV 470
            .....:|:.:.|:.:..|.:...|:| ||.  .|..:| :.|:....|.|.||:  .||...|
  Rat   376 VVPGNSRVPDRDICVGNYVIPQDTLVSLCH--YATSRDPAQFREPNSFNPARWLGEGPAPHPF-- 436

  Fly   471 NVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDV------SFVKPLETEFEFLLAPKT 529
                ||:  |||.|:|||.|:|..|:|:.:.||:::..|:|      ..|||:.   ..:|.|:.
  Rat   437 ----ASL--PFGFGKRSCIGRRLAELELQMALAQILTHFEVLPEPGALPVKPMT---RTVLVPER 492

  Fly   530 PLSLRLSDR 538
            .:.|:..||
  Rat   493 SIHLQFVDR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	119/480 (25%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	119/483 (25%)