DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and Cyp11b1

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001028401.2	Gene:	Cyp11b1 / 110115	MGIID:	88583	Length:	501	Species:	Mus musculus

Alignment Length:	505	Identity:	112/505 - (22%)
Similarity:	215/505 - (42%)	Gaps:	82/505 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PKRI-PFLG------TKWIFLL-FFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRD 121
            ||.: ||..      .||:.:: ..|......||.....:.|:.|.|....: ....||.:...:
Mouse    34 PKTLQPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHSV-GKTQIVFVTLPE 97

  Fly   122 DLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNF 186
            |:||:.:..|.:|.|.|.|..:::|:.|.   ...|:....||.|...|..|..::.||:.:|.|
Mouse    98 DVEKLYQVESTHPCRMPLESWIVHRELRG---LGRGVFLLNGPEWYFNRLQLNPNVLSPKAVQKF 159

  Fly   187 LPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMG--------------LEAVCTLMLGRRMG 237
            :|.::.:..||::.|:.:.            |.::.|              :||...::.|.|:|
Mouse   160 VPLVDGIARDFVDNLKKKM------------LESVHGSFSMDFQSSVFNYTIEASHFVLFGERLG 212

  Fly   238 FLAIDTKQPQKISQLAAAVKQLFISQRDSYYGLGLWKYFPTKTYRDFARAEDLIYDVISEIIDH- 301
            .:..|. .|..:..|.........:.:..|....|.::..|:.:::...:.|.|.:.:::.|.:
Mouse   213 LIGRDL-SPDSLKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENLESWDFISEYVTKCIKNV 276

  Fly   302 --ELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSV 364
              ||.|.:..:.....|....|::.::.::...:::          ||...:|.:..|:.....:
Mouse   277 YRELAEGRPQSWSVTAELVAERTLSMDAIQANSMEL----------IAGSTDTTSTPLVMTFFEL 331

  Fly   365 TGDPGAMPRILSEFCEYRDTNIL---QDALTNATYTKACIQESYRLRPTAFCLARILEEDMELSG 426
            ..:|.....:..|... .:.:|.   |.|:::....:|.::|:.||.|....|.|||..|:.|..
Mouse   332 ARNPDVQQALRQESLA-AEASIAANPQKAMSDLPLLRAALKETLRLYPVGTFLERILSSDLVLQN 395

  Fly   427 YSLNAGTVVLCQNMIACHKD-SNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPG 490
            |.:.||| ||..|:.:..:: :.|...:::.|:||:: ...:|.        .:.||.|.|.|.|
Mouse   396 YHVPAGT-VLNVNLYSMGRNPAVFPRPERYMPQRWLE-RKRSFK--------HLAFGFGVRQCLG 450

  Fly   491 KRFVEMEVVLLLAKMVLAFDVSFVKPLETE--------FEFLLAP-KTPL 531
            :|..|.|::|||..::.:|.|      ||:        :.|:|.| .:||
Mouse   451 RRLAEAEMMLLLHHVLKSFHV------ETQEKEDVRMAYRFVLMPSSSPL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	110/500 (22%)
Cyp11b1	NP_001028401.2	p450	44..497	CDD:278495	108/495 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820