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Protein Alignment shd and Cyp27a1

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_077226.2	Gene:	Cyp27a1 / 104086	MGIID:	88594	Length:	533	Species:	Mus musculus

Alignment Length:	513	Identity:	126/513 - (24%)
Similarity:	227/513 - (44%)	Gaps:	78/513 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PKRIPFLGT-KWIFLLFFRRYKM----------TKLHEVYADLNRQYGDIVLEVMPSNVPIVHLY 118
            |..:|..|| :::|.||.:.|.:          ||...::......|.::.|    ::.|:
Mouse    59 PAELPGTGTLQFLFQLFLQGYVLHLPDLQVLNKTKYGPMWTTSFGTYTNVNL----ASAPL---- 115

  Fly   119 NRDDLEKVLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVL 183
                ||:|::...|||.|...:   .::..|..:..:.||...||..|..||.:|...:..|...
Mouse   116 ----LEQVMRQEGKYPIRDHMD---QWKDHRDHKGLTYGIFIAQGEQWYHLRQALKQRLLKPDEA 173

  Fly   184 QNFLPALNAVCDDFI---ELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQ 245
            ..:..|||.|..|||   :.:||..:... .||:...|...:.|||:..::..:|:|.|     :
Mouse   174 ALYTDALNEVISDFITRLDQVRAESESGD-QVPDMAHLLYHLALEAITYILFEKRIGCL-----K 232

  Fly   246 PQKISQLAAAVKQLFISQRDSYY--GLGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELEELKK 308
            |......||.::.:.|..::|.|  .|..|.......::.:....|.|:....::||.:::|||
Mouse   233 PSIPEDTAAFIRSVAIMFQNSVYITFLPKWTRPLLPFWKRYLNGWDNIFSFGKKLIDEKVQELK- 296

  Fly   309 SAACEDDEAAGLR-SIFLNILELKD-LDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDP--- 368
             |..::....|:| |.:|:.|...: |..::......:.:.||::|.:|||.:.|..::..|
Mouse   297 -AQLQETGPDGVRVSGYLHFLLTNELLSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQ 360

  Fly   369 --------GAMPRILSEFCEYRDTNILQDALTNATYTKACIQESYRLRPTAFCLARIL-EEDMEL 424
                    |.:|  ..:..:::|       ..:....||.|:|:.||.|.....:||: |::.|:
Mouse   361 EALHKEVTGVVP--FGKVPQHKD-------FAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEI 416

  Fly   425 SGYSLNAGT-VVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIV-----VPFGV 483
            :|:.....| .|||..::: ...|.|.....|.|.||:...      ..||..|:     ||||.
Mouse   417 NGFLFPKNTQFVLCHYVVS-RDPSVFPEPNSFQPHRWLRKK------EADNPGILHPFGSVPFGY 474

  Fly   484 GRRSCPGKRFVEMEVVLLLAKMVLAFDVSF---VKPLETEFEFLLAPKTPLSLRLSDR 538
            |.|||.|:|..|:|:.|:|:::|..::::.   :..::|....:|.|...:.|....|
Mouse   475 GVRSCLGRRIAELEMQLMLSRLVQKYEIALAPGMGEVKTVSRIVLVPSKKVRLHFLQR 532

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.