Protein Alignment shd and cyp27a1

DIOPT Version :10

• Sequence 1: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_002933986.3
• Gene: cyp27a1 / 100145331
• XenbaseID: XB-GENE-984298
• Length: 557
• Species: Xenopus tropicalis
• Alignment Length: 492
• Identity: 110/492 - (22%)
• Similarity: 229/492 - (46%)
• Gaps: 41/492 - (8%)

  Fly    61 DIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEK 125
            |:|||..:     |.::..|.|.| :...||:.....:.||.:....: ....:|::.:.:.|::
 Frog    88 DLPGPSLL-----KNLYYYFLRGY-LLHTHELQLIYKKMYGPLWRSEI-GKYKMVNIADPEVLQR 145

  Fly   126 VLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPAL 190
            :::...|||.|...::   ::..|..|..:.|...|:|..|.::||:|...:..|....::...:
 Frog   146 LVRQEGKYPMRNKEDV---WKAHRDKRKLAYGPFTEEGHQWYQIRSALNKKMLKPSEAASYAGGI 207

  Fly   191 NAVCDDFIELLRARR--DPDTLVVPNFEELANLM---GLEAVCTLMLGRRMGFLAIDTKQPQKIS 250
            |.|..||::.|:..|  .|...:|   .:|||.:   ..|.:..::...|:|  .:|.:.|.:..
 Frog   208 NEVVTDFMDRLQDMRKASPSGDMV---NDLANALYRFAFEGISNIVFETRIG--CLDKQIPPETQ 267

  Fly   251 QLAAAVKQLFISQRDSYYGLGL--WKYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACE 313
            :...::..:|   ::|.|...|  |.......:..:....|.|:|....:||.::.|: :|...:
 Frog   268 KFIDSIGYMF---KNSVYVTFLPHWTRGILPYWDHYIEGWDNIFDFGKHLIDKKMSEI-QSRLDK 328

  Fly   314 DDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEF 378
            .:|..|....:|  |...:|.:.:...::.:.:.||::|.:|||.:.:..:..||.....:..|.
 Frog   329 GEEVEGEYLTYL--LSSANLTMGEVYGSVCELLLAGVDTTSNTLCWAMYHLARDPELQQAVYEEV 391

  Fly   379 CEY--RDTNILQDALTNATYTKACIQESYRLRPTAFCLARIL-EEDMELSGYSLNAGTVVLCQNM 440
            ...  .|...:.:.:.|....:..|:|:.||.|.....|||: |:::|:..|.....|:.:..:.
 Frog   392 SSAAPMDRIPVAEDIPNMPLLRGVIKETLRLYPVIPTNARIVSEKEVEIGEYRFPKNTLFVLSHY 456

  Fly   441 IACHKDSNFQGAKQFTPERWI-DPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAK 504
            .....:.||:...:|.|:||: |...::...:      .:|||.|.|:|.|||..|:|:.|.|::
 Frog   457 AIARDEENFEDPLKFKPQRWLRDGGMKHHPFS------SIPFGYGVRACLGKRIAELEMHLALSR 515

  Fly   505 MVLAFDVSF---VKPLETEFEFLLAPKTPLSLRLSDR 538
            ::..|::.:   .:.:::....:|:|..|::|:..:|
 Frog   516 VIRMFELRWDPKGEDIKSIARIVLSPSKPVNLQFLER 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	98/447 (22%)
cyp27a1	XP_002933986.3	CYP27A1	118..547	CDD:410739	98/449 (22%)