DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shd and cyp24a1

DIOPT Version :9

Sequence 1:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001082927.1	Gene:	cyp24a1 / 100004700	ZFINID:	ZDB-GENE-060825-1	Length:	505	Species:	Danio rerio

Alignment Length:	497	Identity:	129/497 - (25%)
Similarity:	223/497 - (44%)	Gaps:	63/497 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 IPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEKV 126
            ||||...|..|:   .:...|...:.:.||.....::::|.| ..:...:...||:.:...||.:
Zfish    52 IPGPTNWPLFGS---LIEVIRNGGLKRQHETLIHFHKKFGKI-FRMKLGSFESVHIGSPCLLEAL 112

  Fly   127 LKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPALN 191
            .:....||.|...:....||..|.:.|   |::..:|..|||:||:....:..|..:......:|
Zfish   113 YRKEGSYPERLEIKPWKAYRDMRDEAY---GLLILEGRDWQRVRSAFQQKLMKPTEVMKLDGKIN 174

  Fly   192 AVCDDFIELL-RARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQKISQLAAA 255
            .|..|.|:.: :.....|.|.   ||  .|....|.:|.::..:|.|.|. |:...:.: ....|
Zfish   175 EVAADLIKRIGKVNGKMDALY---FE--LNKWSFETICYVIYDKRFGLLQ-DSVSKEGM-DFITA 232

  Fly   256 VKQLFISQRDSYYG------LGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACED 314
            ||.:.     |.:|      :.|.|...|||::|...|.|.|:......||..|:  |:|....|
Zfish   233 VKTMM-----STFGTMMVTPVELHKTLNTKTWKDHTEAWDRIFSTAKHYIDKNLQ--KQSNGEAD 290

  Fly   315 DEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEFC 379
            |   .|..||.|    .:|..::..:|..:....|:||.||::|:|:.:::.:|.|..::|.|
Zfish   291 D---FLSDIFHN----GNLTKKELYAATTELQVGGVETTANSMLWVIFNLSRNPCAQGKLLKE-- 346

  Fly   380 EYRDTNILQDA-----------LTNATYTKACIQESYRLRPTAFCLARILEEDMELSGYSLNAGT 433
                   :||.           :.:..|.|||::||.|:.|:....:|.|::|..|..|:|..||
Zfish   347 -------IQDVVPAGQTPRAEHIKSMPYLKACLKESMRVSPSVPFTSRTLDKDTVLGDYTLPKGT 404

  Fly   434 VVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEV 498
            |::..:......:..|...:||.||||::   |..::   |....||||||:|.|.|:|..|:::
Zfish   405 VLMLNSQAIGVSEEYFDNGRQFRPERWLE---EKSSI---NPFAHVPFGVGKRMCIGRRLAELQI 463

  Fly   499 VLLLAKMVLAFDV--SFVKPLETEFEFLLAPKTPLSLRLSDR 538
            .|.|..::..:.:  :.::|:::.....|.|...|.:....|
Zfish   464 QLGLCWILRDYKIVATDLEPVDSLHSGTLVPSRELPVAFVPR 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shd	NP_001261843.1	p450	63..528	CDD:299894	125/484 (26%)
cyp24a1	NP_001082927.1	p450	53..493	CDD:278495	124/482 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920