Protein Alignment Gbs-70E and PPP1R3E

DIOPT Version :10

• Sequence 1: NP_648708.2
• Gene: Gbs-70E / 39588
• FlyBaseID: FBgn0036428
• Length: 384
• Species: Drosophila melanogaster
• Sequence 2: NP_001263247.1
• Gene: PPP1R3E / 90673
• HGNCID: 14943
• Length: 279
• Species: Homo sapiens
• Alignment Length: 192
• Identity: 55/192 - (28%)
• Similarity: 88/192 - (45%)
• Gaps: 16/192 - (8%)

  Fly   153 SRGP--KKHVIFADDEGLSLTEVRVM--SEPSNVPPYWSMKFLEQITQGLVSPHPPDQWTVDFK- 212
            ||.|  :|.|.|||..||.|..||..  .|...||.:..::......:......|..:...:.:
Human    79 SRSPDTRKRVRFADALGLELAVVRRFRPGELPRVPRHVQIQLQRDALRHFAPCQPRARGLQEARA 143

  Fly   213 --QPASDYLSFRQKIERDFVSLENVIVKDEESIVVGTIKVKNIDFQKEIIVRVTWDDWKSQQDIF 275
              :|||: ..|..::....:.||.  .:.....|.|:.:|.::.::|.:.||.:.|.|:||::..
Human   144 ALEPASE-PGFAARLLTQRICLER--AEAGPLGVAGSARVVDLAYEKRVSVRWSADGWRSQREAP 205

  Fly   276 CTYARAYGPATCAHVVFDTFSFKITLPPSSKRLEFCICYRTNETEYWDNNDGKNYTISKRSP 337
            ..||....|...|    |.|:|::..||....|.|.:.||....|:||||.|::|.:  |.|
Human   206 AAYAGPAPPPPRA----DRFAFRLPAPPIGGALLFALRYRVTGHEFWDNNGGRDYAL--RGP 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gbs-70E	NP_648708.2	PBD_PPP1R3	<136..198	CDD:455118	16/48 (33%)
		CBM_21	224..332	CDD:427265	32/107 (30%)
PPP1R3E	NP_001263247.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..86		3/6 (50%)
		PBD_PPP1R3	<79..110	CDD:455118	14/30 (47%)
		PP1-binding motif	87..90		1/2 (50%)
		CBM_21	156..258	CDD:427265	32/107 (30%)
		Glycogen-binding motif	176..198		6/21 (29%)
		Substrate-binding motif	248..256		5/7 (71%)