DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mpcp2 and PIC2

DIOPT Version :9

Sequence 1:	NP_001246757.1	Gene:	Mpcp2 / 39587	FlyBaseID:	FBgn0026409	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_010973.3	Gene:	PIC2 / 856779	SGDID:	S000000855	Length:	300	Species:	Saccharomyces cerevisiae

Alignment Length:	289	Identity:	140/289 - (48%)
Similarity:	192/289 - (66%)	Gaps:	15/289 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 KYFALCGIGGILSCGTTHTFVVPLDLVKCRLQVDQAKYKNLVHGFKVTVAEEGARGLAKGWFPTL 124
            :::|.|.:|||::||.||:.:.|||||||||||:...|.:.:.||:..:|.||.:.:..|:..|.
Yeast    16 EFYATCTLGGIIACGPTHSSITPLDLVKCRLQVNPKLYTSNLQGFRKIIANEGWKKVYTGFGATF 80

  Fly   125 LGYSAQGLCKFGLYELFKVKYAEIIGEENAYLYRTSLYLAASASAEFFADIALAPFEAAKVKIQ- 188
            :|||.||..|:|.||.||..|:..:..      ..::||.|||:|||.|||.|.||||.|||.|
Yeast    81 VGYSLQGAGKYGGYEYFKHLYSSWLSP------GVTVYLMASATAEFLADIMLCPFEAIKVKQQT 139

  Fly   189 TIPGYANNFREAVPKMLKEE-GVNAFYKGLVPLWMRQIPYTMMKFACFERTVELLYKYVVPKPRA 252
            |:|.:.||..:...||..|. |:.|||||:||||.|||||||.||..||:.|:.:|. |:||.:.
Yeast   140 TMPPFCNNVVDGWKKMYAESGGMKAFYKGIVPLWCRQIPYTMCKFTSFEKIVQKIYS-VLPKKKE 203

  Fly   253 DCTKGEQLIVTFAAGYIAGVFCAVVSHPADVVVSKLN-QAKGASAISVA-----KSLGFSGMWNG 311
            :....:|:.|:|..||:||:.||.|||||||:|||:| :.|...::|||     :.:||:|:|||
Yeast   204 EMNALQQISVSFVGGYLAGILCAAVSHPADVMVSKINSERKANESMSVASKRIYQKIGFTGLWNG 268

  Fly   312 LTPRIIMIGTLTALQWFIYDGVKVALGIP 340
            |..||:||||||:.||.|||..|..:|:|
Yeast   269 LMVRIVMIGTLTSFQWLIYDSFKAYVGLP 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mpcp2	NP_001246757.1	Mito_carr	58..142	CDD:278578	37/81 (46%)
		Mito_carr	<175..245	CDD:278578	40/71 (56%)
		Mito_carr	260..338	CDD:278578	44/83 (53%)
PIC2	NP_010973.3	Mito_carr	23..102	CDD:395101	37/78 (47%)
		Mito_carr	103..190	CDD:395101	48/92 (52%)
		Mito_carr	214..293	CDD:395101	43/78 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I1616
eggNOG	1	0.900	-	-		E1_KOG0767
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135053
Inparanoid	1	1.050	267	1.000	Inparanoid score	I609
Isobase	1	0.950	-	0.834419	Normalized mean entropy	S396
OMA	1	1.010	-	-		QHG55239
OrthoFinder	1	1.000	-	-		FOG0001887
OrthoInspector	1	1.000	-	-		otm46546
orthoMCL	1	0.900	-	-		OOG6_101022
Panther	1	1.100	-	-	LDO	PTHR45671
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2231
SonicParanoid	1	1.000	-	-		X1083
TreeFam	1	0.960	-	-
	15	14.810