DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4613 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_001261841.1	Gene:	CG4613 / 39586	FlyBaseID:	FBgn0036427	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	271	Identity:	104/271 - (38%)
Similarity:	147/271 - (54%)	Gaps:	32/271 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 NRCAS-------CT-CGV-PNVNRIVGGTQVRTNKYPWIAQIIRGTFLFCGGTLINDRYVLTAAH 177
            |.|.|       |: ||. |..:|||||..|...::||.|.:..|....|||:::..|:|:||||
Human   194 NNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAH 258

  Fly   178 CVHGMDMRGVSVRLLQLDRSSTHLG-VTRSVAFAH---------AHVGYDPVSLVHDIALLRLDQ 232
            |:|       |.||.:|.....|.| |:.|....|         .|..|...:..:|:|||||..
Human   259 CMH-------SFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQT 316

  Fly   233 PIPLVDTMRPACLPSNWLQNF-DFQKAIVAGWGLSQEGGSTSS-VLQEVVVPIITNAQCRATS-Y 294
            .:...||:...|||:. .|:| ...:..|:|||.:....:.|| :||:.|||:.:...|.::. |
Human   317 ALNFSDTVGAVCLPAK-EQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVY 380

  Fly   295 RSMIVDTMMCAGYVKTGGRDACQGDSGGPLIVRD-RIFRLAGVVSFGYGCAKPDAPGVYTRVSRY 358
            ...:...|:||||: .|..|||||||||||:..| ..:||.||||:|.|||:|:.||||.:|:.:
Human   381 SGALTPRMLCAGYL-DGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEF 444

  Fly   359 LEWIAVNTRDS 369
            |:||....:||
Human   445 LDWIHDTAQDS 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_001261841.1	Tryp_SPc	136..362	CDD:214473	93/239 (39%)
CG4613	NP_001261841.1	Tryp_SPc	137..362	CDD:238113	92/238 (39%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	6/18 (33%)
		Tryp_SPc	217..448	CDD:214473	93/239 (39%)
		Tryp_SPc	218..451	CDD:238113	94/241 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960