DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4613 and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_001261841.1	Gene:	CG4613 / 39586	FlyBaseID:	FBgn0036427	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	321	Identity:	111/321 - (34%)
Similarity:	170/321 - (52%)	Gaps:	39/321 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EGHKQQILSNVLGVASETPSDT--ASSLGS------------------TSLSSSASPVFPLEGGG 115
            :||...:....||..|...||.  .|||..                  |:|..|   |:..||..
Human   134 KGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHS---VYVREGCA 195

  Fly   116 AKAFRVNRCASCTCGVPNVNRIVGGTQVRTNKYPWIAQIIRGTFLFCGGTLINDRYVLTAAHCVH 180
            :......:|.:|.......:|||||.....:::||.|.:....:..|||::|...:::||||||:
Human   196 SGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVY 260

  Fly   181 GMDMR---GVSVRLLQL--DRSSTHLGVTRSVAFAHAHVGYDPVSLVHDIALLRLDQPIPLVDTM 240
            .:.:.   .:.|.|:.|  :.:.:||  ...:.:   |..|.|..|.:||||::|..|:...:.:
Human   261 DLYLPKSWTIQVGLVSLLDNPAPSHL--VEKIVY---HSKYKPKRLGNDIALMKLAGPLTFNEMI 320

  Fly   241 RPACLPSNWLQNF-DFQKAIVAGWGLSQEG-GSTSSVLQEVVVPIITNAQCRATS-YRSMIVDTM 302
            :|.||| |..:|| |.:....:|||.:::| |..|.||....||:|:|..|.... |..:|..:|
Human   321 QPVCLP-NSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSM 384

  Fly   303 MCAGYVKTGGRDACQGDSGGPLIVRD-RIFRLAGVVSFGYGCAKPDAPGVYTRVSRYLEWI 362
            :||||: |||.|:|||||||||:.:: |:::|.|..|||.|||:.:.|||||||:.:|:||
Human   385 LCAGYL-TGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_001261841.1	Tryp_SPc	136..362	CDD:214473	91/234 (39%)
CG4613	NP_001261841.1	Tryp_SPc	137..362	CDD:238113	90/233 (39%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133	18/78 (23%)
		Tryp_SPc	216..444	CDD:214473	91/234 (39%)
		Tryp_SPc	217..447	CDD:238113	92/235 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56985
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960