Protein Alignment CG4613 and TMPRSS3

DIOPT Version :10

• Sequence 1: NP_648707.2
• Gene: CG4613 / 39586
• FlyBaseID: FBgn0036427
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: NP_076927.1
• Gene: TMPRSS3 / 64699
• HGNCID: 11877
• Length: 454
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 111/321 - (34%)
• Similarity: 170/321 - (52%)
• Gaps: 39/321 - (12%)

  Fly    71 EGHKQQILSNVLGVASETPSDT--ASSLGS------------------TSLSSSASPVFPLEGGG 115
            :||...:....||..|...||.  .|||..                  |:|..|   |:..||..
Human   134 KGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHS---VYVREGCA 195

  Fly   116 AKAFRVNRCASCTCGVPNVNRIVGGTQVRTNKYPWIAQIIRGTFLFCGGTLINDRYVLTAAHCVH 180
            :......:|.:|.......:|||||.....:::||.|.:....:..|||::|...:::||||||:
Human   196 SGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVY 260

  Fly   181 GMDMR---GVSVRLLQL--DRSSTHLGVTRSVAFAHAHVGYDPVSLVHDIALLRLDQPIPLVDTM 240
            .:.:.   .:.|.|:.|  :.:.:||  ...:.:   |..|.|..|.:||||::|..|:...:.:
Human   261 DLYLPKSWTIQVGLVSLLDNPAPSHL--VEKIVY---HSKYKPKRLGNDIALMKLAGPLTFNEMI 320

  Fly   241 RPACLPSNWLQNF-DFQKAIVAGWGLSQEG-GSTSSVLQEVVVPIITNAQCRATS-YRSMIVDTM 302
            :|.||| |..:|| |.:....:|||.:::| |..|.||....||:|:|..|.... |..:|..:|
Human   321 QPVCLP-NSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSM 384

  Fly   303 MCAGYVKTGGRDACQGDSGGPLIVRD-RIFRLAGVVSFGYGCAKPDAPGVYTRVSRYLEWI 362
            :||||: |||.|:|||||||||:.:: |:::|.|..|||.|||:.:.|||||||:.:|:||
Human   385 LCAGYL-TGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_648707.2	Tryp_SPc	136..362	CDD:214473	91/234 (39%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:464747	18/78 (23%)
		Tryp_SPc	216..444	CDD:214473	91/234 (39%)