Protein Alignment CG4613 and PLAT

DIOPT Version :10

• Sequence 1: NP_648707.2
• Gene: CG4613 / 39586
• FlyBaseID: FBgn0036427
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 105/335 - (31%)
• Similarity: 147/335 - (43%)
• Gaps: 77/335 - (22%)

  Fly    86 SETPSDTASSLGSTSLSSSASPVFPLEGGGAKAF---RVNR------C--ASC-TCGVPNVN--- 135
            ::.||..|..||..:...:..       |.||.:   ..||      |  .|| |||:...:
Human   251 AQNPSAQALGLGKHNYCRNPD-------GDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQ 308

  Fly   136 -RIVGGTQVRTNKYPWIAQIIR------GTFLFCGGTLINDRYVLTAAHCVHGMDMRGVSVRLLQ 193
             ||.||.......:||.|.|..      |....|||.||:..::|:||||..
Human   309 FRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ------------- 360

  Fly   194 LDRSSTH-----LGVTRSVAFAH-----------AHVGYDPVSLVHDIALLRLDQPIPLV----D 238
             :|...|     ||.|..|....           .|..:|..:..:|||||:|.......    .
Human   361 -ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESS 424

  Fly   239 TMRPACLPSNWLQNFDFQKAIVAGWGLSQEGGST--SSVLQEVVVPIITNAQCRATSYRSM---I 298
            .:|..|||...||..|:.:..::|:| ..|..|.  |..|:|..|.:..:::|  ||...:   :
Human   425 VVRTVCLPPADLQLPDWTECELSGYG-KHEALSPFYSERLKEAHVRLYPSSRC--TSQHLLNRTV 486

  Fly   299 VDTMMCAGYVKTGG-----RDACQGDSGGPLI-VRDRIFRLAGVVSFGYGCAKPDAPGVYTRVSR 357
            .|.|:|||..::||     .|||||||||||: :.|....|.|::|:|.||.:.|.|||||:|:.
Human   487 TDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTN 551

  Fly   358 YLEWIAVNTR 367
            ||:||..|.|
Human   552 YLDWIRDNMR 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_648707.2	Tryp_SPc	136..362	CDD:214473	85/262 (32%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005	11/51 (22%)
		Tryp_SPc	313..559	CDD:238113	85/262 (32%)