Protein Alignment CG4613 and KLKB1

DIOPT Version :10

• Sequence 1: NP_648707.2
• Gene: CG4613 / 39586
• FlyBaseID: FBgn0036427
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: XP_011530232.1
• Gene: KLKB1 / 3818
• HGNCID: 6371
• Length: 649
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 100/285 - (35%)
• Similarity: 152/285 - (53%)
• Gaps: 23/285 - (8%)

  Fly   101 LSSSASP---VFPLEGGGAKAFRV-NRCASCTCGVPNVNRIVGGTQVRTNKYPWIAQI---IRGT 158
            ||...||   .:..:|....:.|: |...:..|......||||||.....::||...:   :...
Human   362 LSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQ 426

  Fly   159 FLFCGGTLINDRYVLTAAHCVHGM---DMRGVSVRLLQLDRSSTHLGVTRSVAFAH-----AHVG 215
            ...|||:||..::|||||||..|:   |:..:...:|.|.      .:|:...|:.     .|..
Human   427 RHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLS------DITKDTPFSQIKEIIIHQN 485

  Fly   216 YDPVSLVHDIALLRLDQPIPLVDTMRPACLPSNWLQNFDFQKAIVAGWGLSQEGGSTSSVLQEVV 280
            |......|||||::|..|:...:..:|.||||....:..:....|.|||.|:|.|...::||:|.
Human   486 YKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVN 550

  Fly   281 VPIITNAQCRATSYRSMIVDTMMCAGYVKTGGRDACQGDSGGPLIVR-DRIFRLAGVVSFGYGCA 344
            :|::||.:|:.......|...|:|||| |.||:|||:|||||||:.: :.::||.|:.|:|.|||
Human   551 IPLVTNEECQKRYQDYKITQRMVCAGY-KEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCA 614

  Fly   345 KPDAPGVYTRVSRYLEWIAVNTRDS 369
            :.:.|||||:|:.|::||...|:.|
Human   615 RREQPGVYTKVAEYMDWILEKTQSS 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_648707.2	Tryp_SPc	136..362	CDD:214473	88/237 (37%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519	6/23 (26%)
		Tryp_SPc	402..632	CDD:238113	87/236 (37%)