DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4613 and tmprss4b

DIOPT Version :9

Sequence 1:	NP_001261841.1	Gene:	CG4613 / 39586	FlyBaseID:	FBgn0036427	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001119849.1	Gene:	tmprss4b / 327651	ZFINID:	ZDB-GENE-030131-5862	Length:	432	Species:	Danio rerio

Alignment Length:	360	Identity:	112/360 - (31%)
Similarity:	177/360 - (49%)	Gaps:	64/360 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SICDRSWAVYNYKPPSRGYFY---PKPERLPPLPVNGSTTSSTGPPPGVQSDFIDDLIEGHKQQI 77
            ::|..:|...:.:...:...|   |:..|:|                 |:|.|.      :.|..
Zfish   116 TVCADNWRTKHTRLTCQQLGYTVSPRSTRIP-----------------VRSLFF------NPQNE 157

  Fly    78 LSNVLGVASETPSDTASSLGSTSLSSSASPVFPLEGGGAKAFRVNRCASCT-CG-VPNVNRIVGG 140
            .:.|...:::  ||..|.|.:::..||.|.|               ..||: || |...:|||||
Zfish   158 FATVSNDSAQ--SDIQSFLSASNKCSSGSVV---------------SVSCSDCGEVVGEDRIVGG 205

  Fly   141 TQVRTNKYPWIAQIIRGTFLFCGGTLINDRYVLTAAHCVHGMDMRGVSVRLLQLDRSSTHLGVTR 205
            .:.....:||...:.......|||:|::..::::||||..|        |..:|.|.:..||.|:
Zfish   206 VETSIEHWPWQVSLQFNHRHMCGGSLLSTSWIISAAHCFTG--------RTQELSRWTVVLGQTK 262

  Fly   206 -------SVAFAHAHVGYDPVSLVHDIALLRLDQPIPLVDTMRPACLPSNWLQNFDFQKAIVAGW 263
                   ||.....|..|:.::...|||:|:|..|:...:::.|.|||.:.|...|.  .:|.||
Zfish   263 VMDVVGVSVDMIVIHKDYNRLTNDFDIAMLKLTWPVKTGESILPVCLPPHQLAIKDM--LVVTGW 325

  Fly   264 GLSQEGGSTSSVLQEVVVPIITNAQC-RATSYRSMIVDTMMCAGYVKTGGRDACQGDSGGPLIVR 327
            ||.:|||:..:|||:..||::..::| :.|.|.|.|...|:|||::: |..|||||||||||:..
Zfish   326 GLLKEGGALPTVLQKASVPLVNRSECSKPTIYSSSITPRMLCAGFLQ-GNVDACQGDSGGPLVYL 389

  Fly   328 DRIFRLAGVVSFGYGCAKPDAPGVYTRVSRYLEWI 362
            ...::|.|:||:|.|||:...||||..|::.|:||
Zfish   390 SSRWQLIGIVSWGVGCAREGKPGVYADVTQLLDWI 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_001261841.1	Tryp_SPc	136..362	CDD:214473	86/233 (37%)
CG4613	NP_001261841.1	Tryp_SPc	137..362	CDD:238113	85/232 (37%)
tmprss4b	NP_001119849.1	SRCR_2	100..179	CDD:292133	15/87 (17%)
		SRCR	105..>175	CDD:278931	14/83 (17%)
		Tryp_SPc	201..424	CDD:214473	86/233 (37%)
		Tryp_SPc	202..427	CDD:238113	87/234 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6379
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910