DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4613 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_001261841.1	Gene:	CG4613 / 39586	FlyBaseID:	FBgn0036427	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	247	Identity:	106/247 - (42%)
Similarity:	148/247 - (59%)	Gaps:	17/247 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 CTCGV--PNVNRIVGGTQVRTNKYPWIAQI-IRGTFLFCGGTLINDRYVLTAAHCVHGMDM---R 185
            |.||:  |: :|||||......::||.|.: |||..: |||.||.||:|:|||||.....|   |
  Rat   566 CDCGLQGPS-SRIVGGAMSSEGEWPWQASLQIRGRHI-CGGALIADRWVITAAHCFQEDSMASPR 628

  Fly   186 GVSVRLLQLDRSSTHLG-VTRSVAFAHAHVGYDPVSLVHDIALLRLDQPIPLVDTMRPACLPSNW 249
            ..:|.|.::.::|...| |:..|:....|..::..|..:|:|||:||.|:....|:||.|||:.
  Rat   629 LWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPAR- 692

  Fly   250 LQNF--DFQKAIVAGWGLSQEGGSTSSVLQEVVVPIITNAQCRATSYRSMIVDTMMCAGYVKTGG 312
             .:|  ..|...:.|||..:|||..||.||:|.|.:|....|. .:||..:...|:||||.| |.
  Rat   693 -SHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCN-EAYRYQVTPRMLCAGYRK-GK 754

  Fly   313 RDACQGDSGGPLIVRDRIFR--LAGVVSFGYGCAKPDAPGVYTRVSRYLEWI 362
            :|||||||||||:.::...|  |||:||:|.||.:|:..||||||:|.:.||
  Rat   755 KDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWI 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_001261841.1	Tryp_SPc	136..362	CDD:214473	100/234 (43%)
CG4613	NP_001261841.1	Tryp_SPc	137..362	CDD:238113	99/233 (42%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486	106/247 (43%)
		Tryp_SPc	576..806	CDD:214473	100/234 (43%)
		Tryp_SPc	577..809	CDD:238113	101/235 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BJ04
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810