DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4613 and Tmprss3

DIOPT Version :9

Sequence 1:	NP_001261841.1	Gene:	CG4613 / 39586	FlyBaseID:	FBgn0036427	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001157248.1	Gene:	Tmprss3 / 140765	MGIID:	2155445	Length:	475	Species:	Mus musculus

Alignment Length:	313	Identity:	105/313 - (33%)
Similarity:	169/313 - (53%)	Gaps:	21/313 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GPPPGVQSDFIDDLIEGHKQQILSNVLGVASETPSDTASSLGSTSLSSSASPVFPLEGGGAKAFR 120
            |.|..|.||.:  .::..::|...:.:.:......|..::|..:        |:..||..:....
Mouse   168 GFPSYVSSDHL--RVDALEEQFQGDFVSINHLLSDDKVTALHHS--------VYMREGCTSGHVV 222

  Fly   121 VNRCASCTCGVPNVNRIVGGTQVRTNKYPWIAQIIRGTFLFCGGTLINDRYVLTAAHCVHGM--- 182
            ..:|::|........|||||......::||...:....:..|||::|...:::||||||:.:
Mouse   223 TLKCSACGTRTGYSPRIVGGNMSSLTQWPWQVSLQFQGYHLCGGSIITPLWIVTAAHCVYDLYHP 287

  Fly   183 DMRGVSVRLLQLDRSSTHLGVTRSVAFAHAHVGYDPVSLVHDIALLRLDQPIPLVDTMRPACLPS 247
            ....|.|.|:.|..|.....:...:.:   |..|.|..|.:||||::|.:|:...:|::|.|||
Mouse   288 KSWTVQVGLVSLMDSPVPSHLVEKIIY---HSKYKPKRLGNDIALMKLSEPLTFDETIQPICLP- 348

  Fly   248 NWLQNF-DFQKAIVAGWGLSQEGGSTSSVLQEVVVPIITNAQCRATS-YRSMIVDTMMCAGYVKT 310
            |..:|| |.:....:|||.:::||..|.||....||:|:|..|.... |..:|..:|:||||:|
Mouse   349 NSEENFPDGKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLK- 412

  Fly   311 GGRDACQGDSGGPLIVRD-RIFRLAGVVSFGYGCAKPDAPGVYTRVSRYLEWI 362
            ||.|:|||||||||:.:: |:::|.|..|||.|||:.:.||||||::.:|:||
Mouse   413 GGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRITSFLDWI 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_001261841.1	Tryp_SPc	136..362	CDD:214473	90/231 (39%)
CG4613	NP_001261841.1	Tryp_SPc	137..362	CDD:238113	89/230 (39%)
Tmprss3	NP_001157248.1	LDLa	96..129	CDD:238060
		SRCR_2	134..233	CDD:292133	13/74 (18%)
		Tryp_SPc	238..465	CDD:214473	90/231 (39%)
		Tryp_SPc	239..468	CDD:238113	91/232 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56985
Inparanoid	1	1.050	179	1.000	Inparanoid score	I3996
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11120
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960