DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4613 and tmprss3

DIOPT Version :9

Sequence 1:	NP_001261841.1	Gene:	CG4613 / 39586	FlyBaseID:	FBgn0036427	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_031752328.1	Gene:	tmprss3 / 100490444	XenbaseID:	XB-GENE-994580	Length:	483	Species:	Xenopus tropicalis

Alignment Length:	316	Identity:	108/316 - (34%)
Similarity:	170/316 - (53%)	Gaps:	28/316 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SDFIDDL---IEGHKQQILSNVLGVASETPSDTASSLGSTSLSSSASPVFPLEGGGAKAFRVNRC 124
            |.::..:   :|..::|...:.:.|   |||...:  |.|||....  :.|.|...:......:|
Frog   172 SSYVSSIYLPVEAVEEQFRRHFVSV---TPSPKFA--GQTSLLQQL--INPSEYCSSGNVITLKC 229

  Fly   125 ASCTCGV-PNVN---RIVGGTQVRTNKYPWIAQII-RGTFLFCGGTLINDRYVLTAAHCVHGMDM 184
            .  .||: |:..   |||||......::||.|.:: :|..| |||:||..::::||||||:  |:
Frog   230 V--VCGLRPSYTSSARIVGGNVSAVGQWPWQASLVFQGVHL-CGGSLITPQWIVTAAHCVY--DL 289

  Fly   185 ---RGVSVRLLQLDRSSTHLGVTRSVAFAHAHVGYDPVSLVHDIALLRLDQPIPLVDTMRPACLP 246
               ....|::.|:.::|........|.....|..|...::.:||||:||..|.....:::|.|||
Frog   290 LYPEWWRVQVGQVSQASESAQTAVPVQKIIYHSKYRSSTMANDIALIRLASPFTFNGSIQPICLP 354

  Fly   247 SNWLQNFDFQKAI-VAGWGLSQEGGSTSSVLQEVVVPIITNAQCRAT-SYRSMIVDTMMCAGYVK 309
             |:.::|...|.. ::|||.::|||.||..:....||:|:|..|... .|..:|..:|:|||:::
Frog   355 -NYREDFPEGKICWISGWGATEEGGDTSQTMDYAGVPLISNRVCNTKYIYGGVIKPSMVCAGFLE 418

  Fly   310 TGGRDACQGDSGGPLIVRD-RIFRLAGVVSFGYGCAKPDAPGVYTRVSRYLEWIAV 364
             ||.|.|||||||||...| .:::|.|..|:|.|||....||||||:|.:|:||.:
Frog   419 -GGVDTCQGDSGGPLACEDSNVWKLMGTTSWGIGCALRYKPGVYTRISSFLDWIHI 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4613	NP_001261841.1	Tryp_SPc	136..362	CDD:214473	89/232 (38%)
CG4613	NP_001261841.1	Tryp_SPc	137..362	CDD:238113	88/231 (38%)
tmprss3	XP_031752328.1	LDLa	96..128	CDD:197566
		SRCR_2	136..236	CDD:406055	16/72 (22%)
		Tryp_SPc	244..472	CDD:238113	89/232 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56985
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910