DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and CYTIP

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_004279.3	Gene:	CYTIP / 9595	HGNCID:	9506	Length:	359	Species:	Homo sapiens

Alignment Length:	360	Identity:	80/360 - (22%)
Similarity:	138/360 - (38%)	Gaps:	75/360 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  2266 FSSLDSLASS-----SSGVSSTTQNVST-----TQETATEFGSFSSLG-SNQSLITAQDVQQIVE 2319
            :||..:|..|     :..:......|:|     .|...|...|.|... |.:.|:|       ||
Human    24 YSSYSTLTGSLTMDDNRRIQMLADTVATLPRGRKQLALTRSSSLSDFSWSQRKLVT-------VE 81

  Fly  2320 EADPPLKTPEAFIIVLQRENPE-----SSIGITLAGGSDYEAKEITIHKILSNTPAAKDGRLKKG 2379
            :.|     .|.|...:|...|:     ||...||            |.||..::||...| |:.|
Human    82 KQD-----NETFGFEIQSYRPQNQNACSSEMFTL------------ICKIQEDSPAHCAG-LQAG 128

  Fly  2380 DRILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVVKALTKKRSSLGSL-SSLNEKPTE 2443
            |.:..:||:|..|.|:::.:.:::: ...::.:.|.:.::::|. |:..:.|..| .:|.:|..|
Human   129 DVLANINGVSTEGFTYKQVVDLIRS-SGNLLTIETLNGTMILKR-TELEAKLQVLKQTLKQKWVE 191

  Fly  2444 ---LDYERKRNYHKASRSL----DLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDED---AE 2498
               |..:..|..|..:.:.    ::|||.:|            ..|.:..|.|| |.|.:   :|
Human   192 YRSLQLQEHRLLHGDAANCPSLENMDLDELS------------LFGPLPGPGPA-LVDRNRLSSE 243

  Fly  2499 ATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAE---IRAQAEDAAASGGGARCVEIVKD 2560
            ::.....:...:...|..:...||...|.|.:|.....:   |..:.:|........|...|...
Human   244 SSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSSSRRNRSISNT 308

  Fly  2561 SCGLGFSI-EGGFDSPLGNRPLIVKKVFMGGAAQK 2594
            |.|....: ||...|..|..|...:|    |:.:|
Human   309 SSGSMSPLWEGNLSSMFGTLPRKSRK----GSVRK 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	21/86 (24%)
		PDZ_signaling	2553..2634	CDD:238492	12/43 (28%)
CYTIP	NP_004279.3	PDZ_signaling	76..161	CDD:238492	27/110 (25%)
CYTIP	NP_004279.3	Interaction with CYTH1	166..188		5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900