DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and Pard3

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_006531583.1	Gene:	Pard3 / 93742	MGIID:	2135608	Length:	1337	Species:	Mus musculus

Alignment Length:	809	Identity:	159/809 - (19%)
Similarity:	261/809 - (32%)	Gaps:	329/809 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1915 ILDLPEI-------KSQVKAASGE-DSTDSGLGESHRSTVNRNCQLGAGGAANNYRSILNTNQRR 1971
            ||||.:|       |.::.|...| |....|.|.|..||..::.::        :.|.|.||
Mouse    58 ILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEI--------FGSELGTN--- 111

  Fly  1972 PLEQQLSQPPAKPPRTSLTPLQPRSMMIPPPPPPLDQESDTDSVFSHTARVATPPEKFALTRTLS 2036
              .....||........:||...|:.|      ||           |..|.:.|    |||...:
Mouse   112 --NVSAFQPYQATSEIEVTPSVLRANM------PL-----------HVRRSSDP----ALTGLST 153

  Fly  2037 SETNTSIASSNTS-------TLTSG----SSAGSQASCS--------SLGSTPAVDLTRRVLKSQ 2082
            |.::.:.:|...|       :.|:|    ::|||..:|.        ||...|: ..:.:..:.
Mouse   154 SVSDNNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDPS-SWSNQFQRD- 216

  Fly  2083 VINGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDGEACSLANRRMKPI-------------- 2133
                     ::|.|:.||..........||:|.:.|:.:     :.|::|:
Mouse   217 ---------NARSSLSASHPMVDRWLEKQEQDEEGTEED-----SSRVEPVGHADTGLENMPNFS 267

  Fly  2134 --SSYKLQQ---------------------------QQIQLGKQLVVDKLINVAAYVELTSDTDD 2169
              ...||.|                           ::::.|.:...:.|.:....:...:|.|.
Mouse   268 LDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDL 332

  Fly  2170 SSRRSDTPAKISAMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELR 2234
            .:||.            |:.:..|:    |..:.:|      :...::|:|.:|..:|.:.   |
Mouse   333 RNRRF------------EQAQHMFR----QAMRARV------IWFHVVPAANKEQYEQLSQ---R 372

  Fly  2235 EK---------------FERSAAAQA-QTQNHSPVIHKVTQK-------PHHERFSSLDSLASSS 2276
            ||               ..||.|..| |....:|.:.:..::       ||....|:....|.:.
Mouse   373 EKNNYSPGRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPAAPAL 437

  Fly  2277 SGVSSTTQNVSTTQET-------------ATEFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTP 2328
            :..|..:.||.:...|             .||...||        ||::||
Mouse   438 APPSVLSTNVGSVYNTKKVGKRLNIQLKKGTEGLGFS--------ITSRDV-------------- 480

  Fly  2329 EAFIIVLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGL 2393
                              |:.|.:     .|.:..||....|.:|||||.|||::.|||:.:.|.
Mouse   481 ------------------TIGGSA-----PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGK 522

  Fly  2394 THRESISVLKTPRPE--VVLVVTRSESLVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKAS 2456
            :..|.:|:|::.:.|  |.|:|.|.|...                   .|.|::.|
Mouse   523 SQEEVVSLLRSTKMEGTVSLLVFRQEEAF-------------------HPREMNAE--------- 559

  Fly  2457 RSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTS 2521
                                  ||  .:..|:.....|||...|..|                |.
Mouse   560 ----------------------PS--QMQTPKETKAEDEDVVLTPDG----------------TR 584

  Fly  2522 ELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFD----SPLGNRPLI 2582
            |.|.......:               ||           |.|||.|::|...    :.||   :.
Mouse   585 EFLTFEVPLND---------------SG-----------SAGLGVSVKGNRSKENHADLG---IF 620

  Fly  2583 VKKVFMGGAAQKTNQVRNGDEILSINGAS 2611
            ||.:..||||.|..::|..|:::::||.|
Mouse   621 VKSIINGGAASKDGRLRVNDQLIAVNGES 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	24/83 (29%)
		PDZ_signaling	2553..2634	CDD:238492	20/63 (32%)
Pard3	XP_006531583.1	DUF3534	2..83	CDD:338230	8/24 (33%)
		PDZ_signaling	272..347	CDD:238492	11/90 (12%)
		PDZ_signaling	465..544	CDD:238492	32/123 (26%)
		PDZ_signaling	588..681	CDD:238492	22/91 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900