DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bbg and DLG5

DIOPT Version :9

Sequence 1:NP_001246755.1 Gene:bbg / 39583 FlyBaseID:FBgn0087007 Length:2637 Species:Drosophila melanogaster
Sequence 2:NP_004738.3 Gene:DLG5 / 9231 HGNCID:2904 Length:1919 Species:Homo sapiens


Alignment Length:2221 Identity:426/2221 - (19%)
Similarity:726/2221 - (32%) Gaps:759/2221 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   477 LSSNIPRLLQKQ----KSETDLKLNLYRSKSKESSPRPPLQRANSAEAPERTFIPVL-LNG---- 532
            ||....|.|.::    |:|..|||.|.:.:......|..|::.      :...:|:| |||    
Human    36 LSPGERRQLDEEAGGAKAELLLKLLLAKERDHFQDLRAALEKT------QPHLLPILYLNGVVGP 94

  Fly   533 -------------------NSKSSNSLESVSSIGSSSSGNSVRSPKGPKPKP-------PERVQS 571
                               :|:||:||.||.:.|           |.|.|.|       .|:|::
Human    95 PQPAEGAGSTYSVLSTMPSDSESSSSLSSVGTTG-----------KAPSPPPLLTDQQVNEKVEN 148

  Fly   572 L---------QKTQIPKLQALPTTPPQQIPKLSMQTFKQSPPTPRSTPVGTPSPTSNREIRFKIQ 627
            |         ::.::.|..|..|          ..|.....|..|..|        :.| |.|||
Human   149 LSIQLRLMTRERNELRKRLAFAT----------HGTAFDKRPYHRLNP--------DYE-RLKIQ 194

  Fly   628 TYESKTQDEDKLPSLFDLVHSQENDKDKDRDSDSLKTHNSITALLAAAAAEAADLSRESPPPLVV 692
            ...:.:.    |.||            :::.:::||                             
Human   195 CVRAMSD----LQSL------------QNQHTNALK----------------------------- 214

  Fly   693 GKCMKIVDDTNTTTCYTSSSSGEED--EDDLDASNREYICEDGEKLGPPELINGPGPSEAYFNMF 755
             :|.::..:|:......|....::.  :||:|...|    |:|:.|....|:          ...
Human   215 -RCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRR----ENGQLLRERNLL----------QQS 264

  Fly   756 WHSNMLPTIGEVEEEFSSLEPQSLT----NGNLVKSEESKKL-----PKMEV---NAGGLAQLTD 808
            | .:|.....|.::|...|..|...    ||:   ||...||     .|:||   :...|.:...
Human   265 W-EDMKRLHEEDQKEIGDLRAQQQQVLKHNGS---SEILNKLYDTAMDKLEVVKKDYDALRKRYS 325

  Fly   809 DKIADHDASATRADTRDEVT---TNQTQEISSSSSSSVKSQ------------------KTT--- 849
            :|:|.|:|..:|.:...|..   ..||:.::....::::.|                  |.|   
Human   326 EKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQN 390

  Fly   850 --------------TTTRVTTTKTSSSSSSSSCSSTVIPDVAFKLQPY-EERDDILSEPITTIHE 899
                          |..|.|..||:..|                 :.| ||||.:.||....:.|
Human   391 KDLQWEMELLQSELTELRTTQVKTAKES-----------------EKYREERDAVYSEYKLIMSE 438

  Fly   900 ERRVLSEQKTLSESRTRDALTGEEQLVTSANSKSSSARFKKISSNDNLLDLGDEQDMQEQPLTAT 964
            ..:|:||         .|.|..|.:|   |.||..|:..:|.::|:.:..|...:|        |
Human   439 RDQVISE---------LDKLQTEVEL---AESKLKSSTSEKKAANEEMEALRQIKD--------T 483

  Fly   965 ITQESS--------LRERLE--CPQDNQSID-------RGTLTLSERGKQLSEKEGLTTYTECET 1012
            :|.::.        ||::.:  |.:..:::.       |......||.|.::|::.:.|.  |:.
Human   484 VTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTL--CDN 546

  Fly  1013 SEKESYLEGQQVLNGKGGFVSQDENSDQPTYEREVSETLTIVNDGEKQVTKKLEQNKEIAGKKGA 1077
            ..:|           :...||            |::|.|..::|..||                 
Human   547 LRRE-----------RDRAVS------------ELAEALRSLDDTRKQ----------------- 571

  Fly  1078 KLLKKTDEERRLEQEAQKLIESYQKVKKEAEKLYKLELADDDQGFDLSAFEQAEEEDKPEVSEEI 1142
                |.|..|.| :|.::.:||  :::|||.....:..:..|...|..:.|.     :.||.|..
Human   572 ----KNDVSREL-KELKEQMES--QLEKEARFRQLMAHSSHDSAIDTDSMEW-----ETEVVEFE 624

  Fly  1143 KEVKDSQPVKVDIQIEEEVKTP----------------NQVIGEVKVEDVNKEIKETVQVSQQEI 1191
            :|.:|.....:...:.|.|..|                :...|.::|.|....|           
Human   625 RETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRI----------- 678

  Fly  1192 KKEVKVSHQETKETFKSEEKDESNELKIVKEE-------VKVTHQDLREQIQEIEAVKVVHKEVK 1249
             .:|.:.:::.|:..|:....|.....:|:..       |...|.:|..|           |:..
Human   679 -NDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQ-----------KDSG 731

  Fly  1250 V-IKESAKVTTTTSHKQATKEVIISKEDH---KNDSALPAVSTTKVEIISPPLEDDLGYVLHKHI 1310
            : ::.............|.||..::..|.   .|..||...|..:.|.:....:|.|...|.|  
Human   732 ISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLK-- 794

  Fly  1311 IFPQ----------EKVKTAPTPL-----------------------------------PKPKPK 1330
            :|||          |.:|.:...|                                   .:.:|.
Human   795 VFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPG 859

  Fly  1331 PPVPTNK------PKMPVNLTK---PKSAPPPVPSKRSELSGSGG------------KPTPTQ-- 1372
            ||..::.      |..|:.:..   |.::...:.|.||:.||..|            .|..|:  
Human   860 PPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFETEVG 924

  Fly  1373 ----RRGSLE--------------------TAQP------PKPLER-IIVGVEQRDEPEKPQPII 1406
                ...||:                    ||.|      .||.:| .|........|:.|..|.
Human   925 PCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKID 989

  Fly  1407 NLASVDLPNVAP-----NSKQATVETTPVVEMPPDELQFESHQLPDDGEKEKDLHQESNDLLSGS 1466
            .|    ||...|     .||:|...|.|......|.::|: |:|        :...||...|.||
Human   990 YL----LPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQ-HRL--------ETSSESEATLVGS 1041

  Fly  1467 SSSSVTTPITTPILVSATSSMDSVQSVIEVVNGMP-------IISNQQTDDDDIDEVAAYDDGMH 1524
            |      |.|:|     .|::.......|.::..|       |.|:...:.|        .|..|
Human  1042 S------PSTSP-----PSALPPDVDPGEPMHASPPRKARVRIASSYYPEGD--------GDSSH 1087

  Fly  1525 LEAEGTKDVRPVQEVTTLTLDREHESDLGTLSNHHSNISSISGINASSNIPAATLISSSIKKTST 1589
            |.|:.:.|    :::|:..:|     :||.......:..|.....|...|||..|........|.
Human  1088 LPAKKSCD----EDLTSQKVD-----ELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASG 1143

  Fly  1590 E-AATTKPAAPQIPGKMELLSS--------NTGTTTTTTTATHHLHQATTTKQLL---VQDYLSY 1642
            | :...:..||..||.....|:        :.||...:.|      .:||...:|   :....|:
Human  1144 ELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLT------PSTTVSSILRNPIYTVRSH 1202

  Fly  1643 ASPPTYSRLPPDGHEFPPNFSEPLIMHSHPLKVTTELS------YEIQKGGKDESSAPPLPKTGP 1701
            ...|..|  ||...:..|....|.:.|..  :::.:||      |...:.....:|.|...:.|.
Human  1203 RVGPCSS--PPAARDAGPQGLHPSVQHQG--RLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGS 1263

  Fly  1702 PATVPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPSDWRKDEKSEKSVRDKIAMFSSNNEL 1766
            .:.:..|..|..:       ||..| |.||:.|                 |.|..:    |::|.
Human  1264 SSNLQFKAERIKI-------PSTPR-YPRSVVG-----------------SERGSV----SHSEC 1299

  Fly  1767 DAIPPAPATAPISSSFTRKPLNRSSENLLDSCSSS--SAPSLKTRAMSVENLNDVQRQYQLAKQL 1829
             :.||            :.|||..:   |.|||.|  ||.:|...|::..:|.:.::.....:: 
Human  1300 -STPP------------QSPLNIDT---LSSCSQSQTSASTLPRIAVNPASLGERRKDRPYVEE- 1347

  Fly  1830 PQLHVADSMYSLNTATPTPSYASLPRRSHGGSYSSGV--------------ERRISFSGEGGDAA 1880
            |: ||.....|      .|...|:.....||.|.|.|              ::.:.|:|....:|
Human  1348 PR-HVKVQKGS------EPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLRSA 1405

  Fly  1881 NRKAA----------ITNI---------LEQRRRSLSKL-----------RGLVIPERPQLLEPI 1915
            ..:.|          ||.:         |....||.|.|           .|...||.|.:::|:
Human  1406 TEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPL 1470

  Fly  1916 LDLPEIKSQVKAASGEDSTDSGLGESHRSTV--------NRNCQLGAGGAANNYRSILNTNQRRP 1972
            ::..|..|...|   :.|:....|::::.|:        ....:||......|...:.       
Human  1471 MEQDEGPSTPPA---KQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVF------- 1525

  Fly  1973 LEQQLSQPPAKPPRTSLTPLQPRSMMIPPPPPPLDQESDT-DSVFSH--------TARVATPPEK 2028
            :.:.....|||.|    ..|.|..:::  ....||..:.| :.|:..        ..:|...||:
Human  1526 VAEVEDDSPAKGP----DGLVPGDLIL--EYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEE 1584

  Fly  2029 FALTRTLSS---------------ETNTSIASSN----TSTLTSGS-------SAGSQASCSSLG 2067
            |...:.|..               |...|....:    ..||..|:       .....|.....|
Human  1585 FTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRG 1649

  Fly  2068 STPA-----VDLTRRVLKSQVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDG------- 2120
            ..|:     .:.:||:..|:|.:..    |:.|::.|:|:....:.:.:.:.:.|.||       
Human  1650 QIPSKYVMDQEFSRRLSMSEVKDDN----SATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALD 1710

  Fly  2121 -----------EACSLANRRMKPISSYKLQQQQIQLGKQL--VVDKLINVA--AYVELTSDTDDS 2170
                       ::.|||.:|::.:....|:...| ||..|  |.:.|:|.|  .:.....:...:
Human  1711 AFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLI-LGPLLDVVKEMLVNEAPGKFCRCPLEVMKA 1774

  Fly  2171 SRRSDTPAKISAMFIDEERK---------ASFK--GDPNQQAKVKVE----------QVKPMVLP 2214
            |:::........:|:|.:|:         ||.|  .:.|:...:.:.          .:.|:|:.
Human  1775 SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIF 1839

  Fly  2215 MLLPSAK-----REPLKQQTTAELREKFERSAAAQAQTQNHSPVIHKVTQKPHHERFSSLDSLAS 2274
            :...|||     |:|:..:.....|...|:..|||...|.:|.....|.|.      .:|.|:.:
Human  1840 IHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQG------GALSSICT 1898

  Fly  2275 SSSGVSSTTQN 2285
            ....:.:..||
Human  1899 QILAMVNQEQN 1909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bbgNP_001246755.1 PDZ_signaling 90..177 CDD:238492
ATP-synt_B <1084..>1109 CDD:304375 9/24 (38%)
PDZ_signaling 2331..2413 CDD:238492
PDZ_signaling 2553..2634 CDD:238492
DLG5NP_004738.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..142 12/54 (22%)
Takusan 130..212 CDD:282652 21/116 (18%)
TPR_MLP1_2 231..353 CDD:285204 32/139 (23%)
COG1340 295..587 CDD:224259 74/378 (20%)
FliJ 310..449 CDD:304890 32/164 (20%)
BAR 417..601 CDD:299863 55/269 (20%)
PDZ_signaling 620..707 CDD:238492 15/98 (15%)
DegQ <702..771 CDD:223343 13/79 (16%)
PDZ_signaling 722..790 CDD:238492 14/78 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1122 50/235 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1187 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1230 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1264 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1306 14/76 (18%)
PDZ 1347..1429 CDD:214570 17/89 (19%)
dbPDZ_assoc 1427..1499 CDD:293216 16/74 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1493 15/61 (25%)
PDZ 1499..1582 CDD:214570 14/95 (15%)
SH3_DLG5 1597..1659 CDD:212794 8/61 (13%)
GuKc 1732..1908 CDD:214504 35/182 (19%)
Guanylate_kin 1740..1907 CDD:279019 34/173 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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