DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and Grip1

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	969	Identity:	183/969 - (18%)
Similarity:	310/969 - (31%)	Gaps:	332/969 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1772 APATAPIS----SSFT--RKPLNRSSEN-----LLDSCSSSSAPSLKTRAMSVENLNDVQRQYQL 1825
            :|...|.|    ..||  |.||....::     ..:..:...|.|.|.|...:..|...:..|
Mouse    18 SPLGLPFSWYVRKEFTCCRSPLQPPEQSPCVHFAREQRARMIAVSFKCRCQILRRLTKDESPY-- 80

  Fly  1826 AKQLPQLHVADSMYSLNTATPTPSYASLPRRSHGG---------------SYSSGVER----RIS 1871
            .|...|....|...::..       .|:|....|.               :.|.|:::    |:|
Mouse    81 TKSASQTKPPDGALAVRR-------QSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVS 138

  Fly  1872 FSGEGGDAANRK--------AAITNILEQRRRSLSKLR-----GLV--IPERPQLLEPILDLPEI 1921
            ...:||.||...        .|:..|      :|:|.|     .|:  :.|| .:||...:||.:
Mouse   139 NLRQGGIAARSDQLDVGDYIKAVNGI------NLAKFRHDEIISLLKNVGER-VVLEVEYELPPV 196

  Fly  1922 KSQVKAASGEDSTDSGLGESHRSTVNRNCQLGAGGAANNYRSIL------NTNQRRPLEQQLSQP 1980
            ..|                 ..|.:.|..::......|.:..::      :.|:.||:
Mouse   197 SVQ-----------------GSSVMFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPV------- 237

  Fly  1981 PAKPPRTSLTPLQPRSMMIPPPPPPLDQESDTD------SVFSHTARVATPPEKFALTRTLSSET 2039
                   .:|.::|..        |.|:|....      ||........|..|..::.:....|.
Mouse   238 -------VITCVRPGG--------PADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEA 287

  Fly  2040 NTSIASSNTSTLTSGSSAGSQASCSSLGSTPAVDLTRRVLKSQVINGEAVALSSRKSILASAKCR 2104
             |.:...:.|.:.|.::| |......:..||...|...:..|...|.:.:.:...||...:.:|.
Mouse   288 -TLLIEYDVSVMDSVATA-SGPLLVEVAKTPGASLGVALTTSVCCNKQVIVIDKIKSASIADRCG 350

  Fly  2105 SAKSRGQEEDNDSTDGEACSLANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDD 2169
            :..........|.|..|.|:||..                                .:..::|.|
Mouse   351 ALHVGDHILSIDGTSMEYCTLAEA--------------------------------TQFLANTTD 383

  Fly  2170 SSRRSDTPAKISAMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELR 2234
            ..:....|        ..:.:.:.||..:    ||:::           |.::.|
Mouse   384 QVKLEILP--------HHQTRLALKGPDH----VKIQR-----------SDRQHP---------- 415

  Fly  2235 EKFERSAAAQAQTQ-NHSPVIHKVTQKPHHERFSSL----------------DSLASSSSGVSST 2282
              ::..|:.|.... ||    |..|..|.|.|..:|                .|..:|.|..|.:
Mouse   416 --WDAWASNQCGVHTNH----HHNTYHPDHCRVPALTFPKALPPNSPPAMVPSSSPTSMSAYSLS 474

  Fly  2283 TQNVST-------TQETAT---------EFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTPEAF 2331
            :.|:.|       |....|         :|.|..||.|:...:..|.|.....|
Mouse   475 SLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTE----------- 528

  Fly  2332 IIVLQRENPESSIGITLAGGSDYEAKEIT----IHKILSNTPAAKDGRLKKGDRILAVNGMSMRG 2392
              |:...:|.:..||.|. ||.:..:.::    |..|.:::||.:.|.|:.|||::|:||:....
Mouse   529 --VVLTADPVTGFGIQLQ-GSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTED 590

  Fly  2393 LTHRESISVLKTPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASR 2457
            .|..|:..:|:.                              ||:..|.|
Mouse   591 STFEEANQLLRD------------------------------SSITSKVT--------------- 610

  Fly  2458 SLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARR--------QLSRGD 2514
             |:::.|:     .||.:   ||:|:.....|.. |..:...||:...:|:        .:.:|.
Mouse   611 -LEIEFDV-----AESVI---PSSGTFHVKLPKK-HSVELGITISSPSSRKPGDPLVISDIKKGS 665

  Fly  2515 AA-KLSTSELLERAAEARN--------AIAAEIRAQAEDAA---------------ASGGGARCV 2555
            .| :..|.||.::.....|        ..|.:|..|.||..               :||.....|
Mouse   666 VAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTV 730

  Fly  2556 EIVKDSCGLGFSIEG---GFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGAS 2611
            |:.:....||.:|.|   .||      |:|:..:..||.|::|..:..||.||:||.:|
Mouse   731 ELKRYGGPLGITISGTEEPFD------PIIISSLTKGGLAERTGAIHIGDRILAINSSS 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	22/85 (26%)
		PDZ_signaling	2553..2634	CDD:238492	21/62 (34%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492	18/86 (21%)
		PDZ_signaling	209..292	CDD:238492	15/105 (14%)
		PDZ_signaling	307..390	CDD:238492	16/114 (14%)
		PDZ_signaling	526..614	CDD:238492	28/147 (19%)
		PDZ_signaling	627..711	CDD:238492	16/84 (19%)
		PDZ_signaling	727..808	CDD:238492	21/63 (33%)
		PDZ_signaling	1058..1138	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810