DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and Whrn

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_001008791.1	Gene:	Whrn / 73750	MGIID:	2682003	Length:	918	Species:	Mus musculus

Alignment Length:	946	Identity:	188/946 - (19%)
Similarity:	303/946 - (32%)	Gaps:	323/946 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1921 IKSQVKAASGEDSTDSGLGESHRSTVNRNCQLGAGGAANNYRSILNTNQRRPLEQQLSQPPAKPP 1985
            :.:|:...|...|:...||.:..:.       |.||.|.  ..:|:.|.|: |.|.|:...::|.
Mouse     1 MNAQLDGLSVSSSSTGSLGSAAAAA-------GGGGGAG--LRLLSANVRQ-LHQALTALLSEPE 55

  Fly  1986 RTSLT-------------------------PLQPR-----SMMIPPPPPPLDQESDTDSVFSHTA 2020
            |...|                         |::.|     .::||        .||......:||
Mouse    56 REQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIP--------RSDQLLFDQYTA 112

  Fly  2021 R-----VATP-------------PEKFALTRTLSSETNTSIASSNTSTLTSGSSAG-----SQAS 2062
            .     ..||             |.:..|.....::.:..:..|    :..||..|     |...
Mouse   113 EGLYLPATTPYRQPAWAAPDGAGPGEVRLVSLRRAKAHEGLGFS----IRGGSEHGVGIYVSLVE 173

  Fly  2063 CSSLGSTPAVDLTRRVLK------SQVINGEAV-ALSSRKSILAS-------------------- 2100
            ..||.....:.:..::|:      ::|.:.||| ||...|.::.|
Mouse   174 PGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWV 238

  Fly  2101 ---AKCRSAKS----------RGQEEDNDST-----------------DGEACSLANR------- 2128
               .:..|..|          |.:|:|..||                 ||.:..|..|
Mouse   239 DPQGRSTSPPSSLPQPHGSTLRQREDDRRSTLHLLQSGDEKKVNLVLGDGRSLGLTIRGGAEYGL 303

  Fly  2129 -----RMKPISSYKLQQQQIQLGKQLV--------------VDKLINVAAYVELTSDTDDSSR-- 2172
                 .:.|.|  :.:...:::|.|::              ..||:..:.::.||  ..|..|
Mouse   304 GIYITGVDPGS--EAESSGLKVGDQILEVNGRSFLNILHDEAVKLLKSSRHLILT--VKDVGRLP 364

  Fly  2173 ----RSDTPAKISAMFIDEE--RKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTA 2231
                ..|....|::..|.|.  ..|.|.||..::...|             |...:.|...|.|.
Mouse   365 HARTTVDQTKWIASSRIGESVANSAGFPGDHTEEGTSK-------------PGFYKGPAGSQVTL 416

  Fly  2232 ELREKFERSAAAQAQTQNHSPVIHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVSTTQETATEF 2296
            .       |...|.:........|.:|::   ||.:.:..||....|..|....|....|.....
Mouse   417 S-------SLGNQTRALLDDQARHLLTEQ---ERATMMYYLAQYRGGTISVEAMVMALFELLNTH 471

  Fly  2297 GSFSSLGSNQSLITAQDVQQIVEEADPPLKTPEAFIIVLQRE--------NPESSIGITLAGGSD 2353
            ..||.|...:|:|:.||:.:...             :||:||        .|...:|.|.:..|.
Mouse   472 AKFSLLSEVRSIISPQDLDRFDH-------------LVLRREIESMKARQPPGPGVGDTYSMVSY 523

  Fly  2354 YEAKEIT-IHKILSNTPAAKDGRLKKGDRI-----LAVNGMSMRGLTH-------------RESI 2399
            .:....| .|...:...:|::..|...|.:     |...|.:.:|.|:             .|.:
Mouse   524 SDTGSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEGTGETTQGSTNALPDVSVDDVKSPSEDL 588

  Fly  2400 SVLKTPRPEVVL---------------------VVTRSESLVVKALTKKRS------SLGSLSSL 2437
            ..:|.|.|...|                     :.:.:.|.:|.:..:.||      .....||.
Mouse   589 PGIKPPPPPPPLAQGHDRLLGQPRKPGREDPAPLSSAAHSGIVFSAPRNRSPPPGTAPTPGPSSA 653

  Fly  2438 NEKPTELDYERKRNYHKASRS-LDLDLDLVS-NEAG-----------ESPVATTPSTGS-VSPPQ 2488
            .:.|:...|....:.:.:||. ||..|.||: :..|           :||.|.||..|: :.||.
Mouse   654 QDSPSSPIYASISHANPSSRKPLDTHLALVNQHPIGPFPRVQSPPHLKSPPAETPGAGACLPPPS 718

  Fly  2489 PA---------------SLHDEDAEATIAGIRARRQL-------------------SRGDA--AK 2517
            |:               .:|..|:|..:..:||..|.                   |..||  .:
Mouse   719 PSEHPDAVGANQHFVLVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGETE 783

  Fly  2518 LSTSELLERAAEARNAIAAE---IRAQAEDAAASGG----GARCVEIVKDSCGLGFSIEGGFDS- 2574
            .|||....:.|.|:|....|   ....||.|....|    .:..|.:.|.:..||.:||||.::
Mouse   784 ASTSGRGRQTASAKNKNGKEQPRTERTAEGANKPPGLLEPTSTLVRVRKSAATLGIAIEGGANTR 848

  Fly  2575 -PLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSING 2609
             ||   |.|| .:..||:|....|::.|..||.:||
Mouse   849 QPL---PRIV-TIQRGGSAHNCGQLKVGHVILEVNG 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	22/129 (17%)
		PDZ_signaling	2553..2634	CDD:238492	22/59 (37%)
Whrn	NP_001008791.1	HN_L-whirlin_R1_like	38..113	CDD:259822	15/83 (18%)
		PDZ_signaling	139..216	CDD:238492	16/80 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		4/25 (16%)
		PDZ_signaling	278..358	CDD:238492	12/83 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		6/32 (19%)
		HN_L-whirlin_R2_like	420..500	CDD:259823	20/95 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..538		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..824		53/263 (20%)
		PDZ_signaling	827..898	CDD:238492	22/58 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900