DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and Pdzph1

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_081277.1	Gene:	Pdzph1 / 69239	MGIID:	1916489	Length:	1238	Species:	Mus musculus

Alignment Length:	1193	Identity:	228/1193 - (19%)
Similarity:	382/1193 - (32%)	Gaps:	387/1193 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1537 QEVTTLTLD-REHESD--------LGTL-SNHHSNI-SSISGINASS-------NIPAATLISSS 1583
            |.|..|..| :.|.|:        ||.| .|...|| :||:|...||       ..|:    .|:
Mouse    18 QNVKDLEEDIKGHTSETVFHQTRTLGKLKENGDENITASINGKQNSSFLVKNEKQAPS----DST 78

  Fly  1584 IKKTSTEAATTKPA-APQ----------------IPGK---------MELLSSNTGT-TTTTTTA 1621
            |.| |.|...|.|| :||                :|||         :|:|....|. .......
Mouse    79 IHK-SMENGYTPPAISPQLEEVLPVAMFNDREKSLPGKITTEDFPNTVEVLKPAKGKFIREVKCG 142

  Fly  1622 THHLHQATT------------TKQLLVQDYLSYASPPTYSRLPPDGHEFPPNFSEPLIMHSHPLK 1674
            ..::|..||            ||:.....:..|:....:......||     ||:...:.:...|
Mouse   143 AFNVHVETTKSIFCKTGAQNLTKRRCPTCHQHYSVQQVWRGSKSRGH-----FSKHRTVLAEEFK 202

  Fly  1675 VTTELSYEIQKGGKDESSAPP--LPKTGPPATVPRKVYRQDLVINV--------------EPAPS 1723
            .....:|   :.|...|..|.  :...|....|.....:|:..||:              .|...
Mouse   203 RRVPSTY---RRGVSRSEVPSVNISIVGKEIMVEYISKKQNTFINICHPNSIGKLTKHRRGPLKH 264

  Fly  1724 LTRDYQRSLSGGTPRKPSDWRKDEKS----------------EKSVRDKIAMFSSN------NEL 1766
            .|.:...|.|......|.:.|.:.:.                :|...|.|.:..|:      .:.
Mouse   265 TTDEPCESASQPGINHPENQRLENQHQSSDAFHDAPCSVNAVQKENSDTIVVSLSSPPRREKEKP 329

  Fly  1767 DAIPPAP--------ATAP--ISSSFTRKPLNRSSENLLDSCSSSSAPSLKTRA--------MSV 1813
            :.:|.||        ||:|  :......|||.:.... .|||..:|:.:|:|.:        ||:
Mouse   330 NTLPSAPDDSEEGESATSPQKVLQITQDKPLEQHCFT-ADSCLPTSSETLRTTSLNNVDLSKMSL 393

  Fly  1814 ENLNDVQRQYQLAKQLPQLHVADSMYSLNTA-TPTPSYA---SLPRRSHGGSYSS---------- 1864
            |:..||..:.:.:..:.:....||.....|| |..|..|   .:|.:...||..|
Mouse   394 EDSRDVDEERKNSSDVRENITPDSQVQPCTAGTNGPLSAVNSIIPIQDASGSEFSPLSFLTLQLL 458

  Fly  1865 -------GVERRISFSGEGGDAANRKAAITNILEQRRRSLSKLRGLVIPERPQ------LLEPIL 1916
                   |.....:..|||.:::|                    .|:.|...|      ||.|..
Mouse   459 GAKADNMGCRGEETLPGEGHESSN--------------------SLLFPVSEQAAKPSPLLSPSH 503

  Fly  1917 DLPEIKSQVKAASGEDSTDSGLG------ESHRSTVNRNCQLGAGGAANNYRSILN--TNQRRPL 1973
            .:......|:......|....:|      :.|...:|:             .|:.|  ::..:||
Mouse   504 RVSRCSEPVETTGNTFSFSQYIGVEREQEKVHYRLINK-------------ASLHNDSSSNIQPL 555

  Fly  1974 EQQLSQPPAKPPRTSLTPLQPRSMMIPPPPPPLDQESDTDSVFSHTARVATPPEKFALTR----- 2033
            |::..|.||         :...|..|..|..||.....:...::.|...|...|:..|:|
Mouse   556 ERKDPQSPA---------VTIASCSILVPKSPLHGNIHSSVEWNQTEDHANHAERAGLSRMEVPV 611

  Fly  2034 --TLSSETNTSIASSN--TSTLTSGS---------------SAGSQASCSSLGSTPAV------- 2072
              ::::|...|:|:.|  .||:.|.|               :.|..||    .:.|.|
Mouse   612 MASITNELEQSLATQNYKESTVDSNSPMAIRNPRESTSYLENVGDDAS----QALPVVKNMCHRN 672

  Fly  2073 --DLTR---RVLKSQV------INGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDGEACSLA 2126
              ||||   ..:.||:      ....:|..::.|..|......|     .::.|.:.|.:.|.|.
Mouse   673 FEDLTRENQNEICSQMDFLQNSSESTSVGHTTEKLFLIDKTLAS-----DDDSNSNRDHKTCGLN 732

  Fly  2127 NRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDDSSRRSDTPAKISAMFIDEERKA 2191
            |.:.:|....:...:                 .|.|       .|.....|.::|...:|
Mouse   733 NFQQEPAECQRTTSR-----------------VYCE-------ESGNQRYPTEVSCHPVD----- 768

  Fly  2192 SFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELR--EKFERSAA---AQAQTQNHS 2251
                                   :||...|::.||.| ..|:.  .|..:..|   .:|...:..
Mouse   769 -----------------------ILLSPQKQKALKDQ-NLEINNPRKLSQELALRGGRASDGSQE 809

  Fly  2252 PVIHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQSLITAQDVQQ 2316
            ..|.:..::  .::|.  |....||:|.||...|.:                  :..||:.||..
Mouse   810 EAIEQWARR--RQQFK--DGKRCSSAGGSSVISNFT------------------EGSITSDDVHS 852

  Fly  2317 I-----VEEADPPLKTPE----AFIIVLQRENPESS----------IGI------TLAGGSDYE- 2355
            :     |:..:....|..    |::......|||.|          :.:      ...|..||.
Mouse   853 VDFGFRVDIEEKGFYTENFHSTAWVFRGDDGNPEDSPRCLSKKPRPVAVRERTVRLFKGTGDYPW 917

  Fly  2356 ------AKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRPEVVLVVT 2414
                  :|.|.:.::.:|: ||::..|:.||.:|:|||..:..:.|.|::.:.|.....:.:||.
Mouse   918 GFRIQFSKPIVVTEVDTNS-AAEEAGLQIGDVVLSVNGTEVTSVEHAEAVHLAKKGLDILTMVVA 981

  Fly  2415 RSESL-------VVKALTKKRSSLGSLSSLNEKPTELDYERKRNY--HKASRSLDLDLDLVSNEA 2470
            ...|.       ..:....||:..|.:....::...|.::....|  |:........||::..|.
Mouse   982 SDISRCPNTPWPTCRGYLHKRTHSGFVKGWRKRWFVLKHDGFLLYYKHRKDEGKWPPLDMIKLEG 1046

  Fly  2471 GESPVATT----------PSTGS 2483
            .|..:..:          |.:||
Mouse  1047 AEVDIDNSLGKPFVFNCMPQSGS 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	22/104 (21%)
		PDZ_signaling	2553..2634	CDD:238492
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492	19/78 (24%)
		PH-like	986..1093	CDD:302622	13/84 (15%)
		PH	993..1094	CDD:278594	13/77 (17%)
		PH-like	1123..1215	CDD:302622
		PH	1125..1216	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900