DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and GOPC

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_065132.1	Gene:	GOPC / 57120	HGNCID:	17643	Length:	462	Species:	Homo sapiens

Alignment Length:	498	Identity:	101/498 - (20%)
Similarity:	192/498 - (38%)	Gaps:	141/498 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2053 SGSSAGSQASCSSLGSTPAVDLTR--RVLKSQ---------VINGEA------VALSSRKSILAS 2100
            :|...|. ||| |:|:...|.:.|  .||:.:         ::.||.      :....|:.:.:.
Human    11 AGGGPGG-ASC-SVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSL 73

  Fly  2101 AKCRSA---KSRGQEEDNDSTDGEACSLANRRMKPISSYKLQQQQIQLGKQLVVDKLINV-AAYV 2161
            :.|.:.   |::...:.|...:.:...|.:...      :.|.:::.|.|: |.|:|:.: :..:
Human    74 SSCFAQLCHKAQSVSQINHKLEAQLVDLKSELT------ETQAEKVVLEKE-VHDQLLQLHSIQL 131

  Fly  2162 ELTSDTDDSSRRSDTPAKISAMFIDE-ERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPL 2225
            :|.:.|..|:......||:|...::| ||:.    :.|::.|:|..|::..|   .|...:.|.|
Human   132 QLHAKTGQSADSGTIKAKLSGPSVEELEREL----EANKKEKMKEAQLEAEV---KLLRKENEAL 189

  Fly  2226 KQQTT--------AELREKF-ERSAAAQAQT----------QNHSPVIHKVTQKPHHERFSSLDS 2271
            ::...        |.|..|: ::..|.:.|.          ..|..:.:::..:.|..|..::..
Human   190 RRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIR 254

  Fly  2272 LASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQ-SLITAQDVQQIVEEADPPLKTPEAFIIVL 2335
            .....:.:....|               :..|.:| ||..:|.|..|.:             ::|
Human   255 ACRGRNDLKRPMQ---------------APPGHDQDSLKKSQGVGPIRK-------------VLL 291

  Fly  2336 QRENPESSIGITLAGGSDYEAKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESIS 2400
            .:|:.| .:||::.||.:: ...|.|.:|....||.:.|.|..||.||||||:::|...|:|:::
Human   292 LKEDHE-GLGISITGGKEH-GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVT 354

  Fly  2401 VLKTPRPEVVLVV-------------------------------------------TRSESLVVK 2422
            :|...|.|:...|                                           |..|..|::
Human   355 ILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQ 419

  Fly  2423 ALTKK-------RSSLGSLSS--LNEKPTELDYERKRNYHKAS 2456
            ...||       ...||:.|.  |::..::|| :....|||.|
Human   420 GFNKKAVTDTHENGDLGTASETPLDDGASKLD-DLHTLYHKKS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	28/81 (35%)
		PDZ_signaling	2553..2634	CDD:238492
GOPC	NP_065132.1	bZIP_2	<166..199	CDD:285017	7/35 (20%)
		PDZ_signaling	286..368	CDD:238492	29/96 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..449		4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900