DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bbg and pdzd2

DIOPT Version :10

Sequence 1:NP_648705.2 Gene:bbg / 39583 FlyBaseID:FBgn0087007 Length:2637 Species:Drosophila melanogaster
Sequence 2:XP_003198698.4 Gene:pdzd2 / 569088 ZFINID:ZDB-GENE-060526-297 Length:2423 Species:Danio rerio


Alignment Length:2992 Identity:577/2992 - (19%)
Similarity:1003/2992 - (33%) Gaps:1008/2992 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 KDRLKKLVKR-QSSVAEDSSFITVLTIN--------EMELLQQRKKEEDVGSGSSPTMEEQIENV 90
            |..::|||:. |.:..|..|  .:.:||        |::.:...|.|||     .|.......|:
Zfish    39 KPAIRKLVEYIQLNFTEVES--PLYSINPLREEIDAEVKAVCLNKSEED-----GPEFGLSFGNI 96

  Fly    91 TVFRLP-GERLGFGLKFQGGTRSTEL-VQKLYIQSCAADSPASKVSTSWGNLREGDEIVSIDGR- 152
            .:|..| |::.|...:.:.|.:...| |..:::.....:|||::.    |:::..||::|::|: 
Zfish    97 PIFGDPEGKKKGVRRRRRKGDKGPVLDVGCIWVTEVKKNSPAARC----GDIKLRDELLSLNGQL 157

  Fly   153 ----DVRELTRI-------DCV-----RGLKDNVAIK----------LVVRNGHGQKPPSE---- 187
                ||...:.:       .|:     |.:|....:.          :.|.|.|.:...||    
Zfish   158 MVGVDVTGASYLADQCWNGGCIYLIMLRRIKRKAPLPPCNGSNGGNFVDVSNDHRRSVSSETAGS 222

  Fly   188 --------------------------EDPQQQEHLSI-----TLNAQPPPPPPVPPRKLVRRQNS 221
                                      :|.:......:     ::.|:...|....|      |::
Zfish   223 PTHNGQNGKRTRKFGVISRSSFTRDSKDSKDSRDCELENGYSSMEAEVTSPESSSP------QDT 281

  Fly   222 KENQAQLLIEKPLTPPPDAEYYLNLLTESIKAGSESDDTASTISTVIDKFSVGSNYSSDSS---- 282
            ..|      :.|:|.|.:.     :::..::.||.:.....:.|.:.:.|...|..|..|.    
Zfish   282 PTN------DSPITGPSEL-----MMSNHMRVGSTATLPCRSRSRMSENFKTESISSEPSGQPRE 335

  Fly   283 ----------------------------------------------------------LNGHELA 289
                                                                      :|||.|.
Zfish   336 GGRIWKMHMVKGQDGLGIQITGGRGSKRSPHGIIVAHVEEGGATQRDGRLKAGDELLMINGHSLV 400

  Fly   290 KVLQPFTLLEQEFLP-LEQPLGHPKLLIPGNNYENVEFKTEKVNVYENVELRSPETTPT------ 347
                  .|..||.:. |....|..:|::...:...|:|     :.|.:..|  |:...|      
Zfish   401 ------GLSHQEAVAILRSTAGLVQLVVASRDESEVDF-----HKYPSTSL--PDLVSTCSGPDA 452

  Fly   348 -PKPRVQLATVEPKKRSIIPMPRKIPTPTKLPIEVTPPRVPILEEPKTPTNNKVDSPK----TPT 407
             |.|..:...:||....:......:||...           ..:..:.....:::.||    :||
Zfish   453 SPSPGEEKENMEPDMEDVRASSLSLPTQDL-----------FTDHDRLDERGRIEGPKGCCRSPT 506

  Fly   408 NELKESPISATKIPKAKFSRAKTEGEIKLHLPAPKQQSPQSKSRIPIVSTPTAQKTVPKPVSPTM 472
                  |:        || |::::|      ...:.:|......:.:.:..|......|   ||.
Zfish   507 ------PM--------KF-RSRSQG------GGSRLESVGEDDELIVENGDTGSDVAEK---PTR 547

  Fly   473 NGTPLSSNIPRLLQKQKSETDLKLNLYRSKSKESSPRPPLQRANSAEAPERTFIP------VLLN 531
            .|...|      |.:|.....::.. |:...|.:.....:|    .|:|.|...|      ||:.
Zfish   548 GGRKHS------LPQQLDTVGIRQE-YQIVKKSARSLSTVQ----VESPWRLAQPSIISNIVLMK 601

  Fly   532 GNSKSSNSLESVSSIGSSSS-----GNSVRS--PKGP-----KPKPPERV-----QSLQKTQIPK 579
            |..|..    ..|.:|...|     |..|::  |.|.     :.|..:.:     :|||  .:..
Zfish   602 GQGKGL----GFSIVGGQDSARGRMGIFVKTIFPNGAAAADGRLKEGDEILEVNGESLQ--GLTH 660

  Fly   580 LQALPTTPPQQIPK----LSMQTFKQSPP-TPRSTPV---GTPSPTSNREIRFKIQTYESKTQDE 636
            .||:.|.  :|:.|    |:::|..:||. ||..||.   .:.||.||             ....
Zfish   661 QQAIQTF--KQLKKGVVTLTVRTRLRSPSLTPCPTPTLLSRSSSPNSN-------------ASGG 710

  Fly   637 DKLPSLFDLVHSQENDKDKDRDSDSLKTHNSITALLAAAAAEAADLSRESPPPLVVGKCMKIVDD 701
            ..:|..||...|::....|||                  ......|::|....|.:|.|      
Zfish   711 TPVPQSFDEGDSRKGPGPKDR------------------IIMEVTLNKEPGVGLGIGAC------ 751

  Fly   702 TNTTTCYTSSSSGEEDEDDLDASNREYICEDGEKLGPPELINGPGPSEAYFNMFWHSNMLPTIGE 766
                 |.|..:|                              .||       ::.||....::.:
Zfish   752 -----CLTLENS------------------------------APG-------IYIHSLAPGSVAK 774

  Fly   767 VEEEFSS----LEPQSLTNGNLVKSEESKKLPKMEVNAGGLAQLTDDKIADHDASATRADTRDEV 827
            ::...|.    ||..|::..:...||....|  .|...|.::.:    |:.|..........|||
Zfish   775 MDGRLSRGDQLLEVDSVSLRHAALSEAYAIL--SECGPGPVSLI----ISRHPNPKVSEQEMDEV 833

  Fly   828 TTNQTQEISSSSSSSVKSQKTTTTTRVTTTKTSSSSSSSSCSSTVIPDVAFKLQPYEERDDILSE 892
            .|..|...|.||.:.....|:.:    .|.|......:.:.|.|:   ..| |:|...:..:.||
Zfish   834 ITRSTHRDSHSSHTLGLPSKSPS----PTVKVKQGEGNPALSWTM---KRF-LEPASRQGSLSSE 890

  Fly   893 ----PITTIHEERRVLSEQKTLSESRTRDALTGEEQLVTSANSKSSSARFKKISSNDNLLDLGDE 953
                ...::|:    :..|.:|||:....  :.::.::.|:.|.::|.. :..:...::...|..
Zfish   891 AELSQYFSVHD----VPSQSSLSETMAMG--SSDDDMLHSSRSCNTSME-ESAAPQPHVYRDGSY 948

  Fly   954 QDMQEQPLTATITQESSLRERLECPQDNQSIDRGTLTLSERGKQLSEKEGLTTYTECETSEKESY 1018
            :.....|.|....:.|....|  ..:..|....|:...|.|...|.::. :..| |.|.|:.|:.
Zfish   949 RGSGSSPTTPECCKASGGTGR--TAETAQQASVGSSPSSVRSPLLRQRR-VICY-EDEPSDDETG 1009

  Fly  1019 LEG-----QQVLNG-KGGFVSQDENSDQPTYEREVSETLTIVNDGEKQVTKKLEQNKEIAGKKGA 1077
            ||.     :::|.| ..|...|:|:|                  |....|..||           
Zfish  1010 LEDDNGPFRRLLRGVSDGHQHQEEDS------------------GIVIATSSLE----------- 1045

  Fly  1078 KLLKKTDEERRLEQEAQKLIESYQKVKKE-AEKLYKLELADDDQGFDLSAFEQ-------AEEED 1134
                       ::.|:|...||::::..| ....|...:..::....||:.|.       .|..:
Zfish  1046 -----------VDDESQDGSESHRQISSEPTTPFYGSSIESEEGTTGLSSAESPFMPIHCVEATN 1099

  Fly  1135 ---KPEVSEEIKEVKDSQPV------KVDIQIEEEVKTPNQVIGEVKVEDVNKEIKETVQVSQQE 1190
               |.|...|.:|||.|..:      :|...:..|...|.|   ..|.||.........||:|..
Zfish  1100 LGVKKEPHREGQEVKRSPKLEHKAVTRVKSMMSIECPNPPQ---RTKGEDPALFPANPAQVTQNC 1161

  Fly  1191 IKKEVKVSHQETKETFKSEEKDESNELKIVKEEVKVTHQDLREQIQEIEAVKVVHKEVKVIKESA 1255
            .:...::.|.         :|.||:||..|     .|.:.:..|..|.|:..:   ::::.....
Zfish  1162 TRPPCRMMHC---------KKGESSELAGV-----CTIETIVLQRGETESFGL---DLEIKSAPL 1209

  Fly  1256 KVTTT-----------TSHKQATKEVIISKEDHKNDSALPAVSTTKVEIISPPLEDDLGYVLHKH 1309
            ||..|           .|.|.:..:.|::..|      .|..:::..||..         ::|  
Zfish  1210 KVLVTGLRPGGVAEREASGKMSFGDEIVTIGD------TPVCTSSYQEICD---------LMH-- 1257

  Fly  1310 IIFPQEKVKTAPTPLPKPKPKPPVPTNKPKMPVNLTKPKSAPPPVPSKRSELSGSGGKPTPTQRR 1374
                                         .:|:.||.....|.....:.|.|..|.|..:.::..
Zfish  1258 -----------------------------NLPITLTLEIKKPVSAVDRLSSLIMSSGCESSSKLE 1293

  Fly  1375 GSLETAQPPKPLERIIVGVEQRDEPEKPQPIINLASVDLPNVA-PNSKQA-TVETTPVVEMPP-- 1435
            .|  .|.|           |:|:..:..|         :|:.. .|:||| |..:.||..:..  
Zfish  1294 AS--RASP-----------EERNHTDTTQ---------IPSSENANAKQAVTTHSMPVTNIDDVV 1336

  Fly  1436 DELQFESHQLPDDGEKEKDLHQESNDLLSGSSS--------------SSVTTPITTPILVSATSS 1486
            .||.....::.|...:|   :.:.:|..:|:.|              .:...|:....|.|.:.:
Zfish  1337 SELNSAESEVKDQSAEE---YSKEDDRGTGAPSQPNPLDFSALDMGNGTCHFPLGKTFLNSYSRN 1398

  Fly  1487 MDSV-QSVIEVVNG---MPIISNQQTDDDDIDEVAAYDDGMHLE-----AEGTKDVRPVQEVTTL 1542
            ..:: :|::.:..|   .|.:.:....|.:.|..   |..:.:|     :||.:|        |.
Zfish  1399 FSNLGESIVPLQKGDGHKPSMYSMVDSDSESDST---DSAVKIEKSQGHSEGPRD--------TD 1452

  Fly  1543 TLDREHESDLGTLSN---HHSNISSISGINA-----SSNIPAATLISSS-IKKTSTEAATTKPAA 1598
            |.:.|.|....|:|.   ..|..||:...|.     |.:.|.|.|::|: :.|.|:.:|..:.  
Zfish  1453 TDEEEVELCFSTVSQSAFSQSEGSSLPDGNGCATRQSVDQPGAKLLTSTDLHKPSSVSAQDRD-- 1515

  Fly  1599 PQIP------GKMELLSSNTG-------------------------TTTTTTTATHHLHQATTTK 1632
            ||.|      || :||:...|                         .|.|.|..|.:....|...
Zfish  1516 PQDPICHEDSGK-DLLNGKNGHAKTTQSNCSDDEKCETMSKSFQTCQTPTDTPVTQNNCHVTPRS 1579

  Fly  1633 QLLVQDYLSYASPPTYSRLPPDGHEFPPNFSEPLIMHSHPLKVT-TELSYEIQKGGKDESSAPPL 1696
            |......||.||                ..:|.|.....|||:| :|.:......||....    
Zfish  1580 QDRTARLLSEAS----------------RSAEKLNTGQAPLKLTVSEPNASHYANGKSSGQ---- 1624

  Fly  1697 PKTGPPATVPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPSDWRKDEKSEKSVRDKIAMFS 1761
                  |::......::.|::       |.|.:.:.|          :...||..||| .:...|
Zfish  1625 ------ASLALASKEKEKVLS-------TLDLKSTFS----------QNQSKSATSVR-SLGTKS 1665

  Fly  1762 SNNELDAIPPAPATAPISSSFTRKPLNRSSENLLDSCSSSSAP----SLKTRAMSVEN------- 1815
            ||:           :|:|      ||.|....:.|..|::|:.    |:|::....|.       
Zfish  1666 SND-----------SPVS------PLLRGRLKVDDKKSNTSSKLKGLSIKSKCKDQEQPVSRSPR 1713

  Fly  1816 -LNDVQRQYQLA-KQLPQLHVADSMYSLNTATPTPSYASLPRRSHGGSYSSGVERRISFSGEGGD 1878
             .:.|||:..:: .|.|:||      |..| |||.|    |:     |..|..:.|:|......:
Zfish  1714 AESPVQRKSLVSPSQSPKLH------SKRT-TPTGS----PK-----STRSSEKSRVSCCKTDQN 1762

  Fly  1879 ----AANRKAAITNILEQRRRSLSKLRGLVIPERPQLLEPILDLPEIKSQVKAASGEDSTDSGLG 1939
                :.|.|....|..::..:.|.|             |..|||.:..|:.:...|         
Zfish  1763 QLTVSTNSKVNPINTAKEELKQLKK-------------EDALDLKQQVSKPEVTVG--------- 1805

  Fly  1940 ESHRSTVNRNCQLGAGGAANNYRSILNTNQRRPLEQQLSQPPAKPPRTSLTPLQPRSMMIPPPPP 2004
                                      || ||..:|.:||.      .:|.||:.||..::.....
Zfish  1806 --------------------------NT-QRTFIEVRLSS------SSSSTPVLPRKEVVNASHL 1837

  Fly  2005 PLD---------QESDTD-SVFSHTARVATPPEKFALTRTLSSETNTSIASSNTSTLTSGSSAGS 2059
            .|.         :||::| |:.|||    .|.|              ||.||::|...:|.:..:
Zfish  1838 SLASLSVDSIKWKESNSDFSLGSHT----IPLE--------------SINSSSSSAQQNGDNKAN 1884

  Fly  2060 QASCSSLGSTPAVDLTRRVLKSQVINGEAVAL---SSRKSILASAKCRSAKS----RGQEEDNDS 2117
            :.:                 :....||:..:|   |:.|.  |::..:::||    ||.:..:.|
Zfish  1885 ETA-----------------EKVFCNGQEESLLRKSTNKD--AASNLKTSKSKLYLRGLDRRSCS 1930

  Fly  2118 TDGEAC----------------SLA-----------------------NRRMK----PISSYKLQ 2139
            ||....                |||                       |||:.    .:||..:.
Zfish  1931 TDAGGSLDTNPFSVRQRIQSFESLASFDRSVIKCIDIPFYAVNSKPTLNRRLSGYAGSVSSQSID 1995

  Fly  2140 QQQIQLGKQLVVDKLINVAAYVELTSDTDDSSRRSDTPAKISAMFIDEERK-ASFKGDP------ 2197
            .:.::......||.|.:..: ::..|.:..::....||:..:...:.:|.| .:.:..|      
Zfish  1996 SRSLRRSFSSCVDNLSSTPS-LQNWSTSSTATNCESTPSNQTTETVMKEMKNETSQNQPTVHTPP 2059

  Fly  2198 -----NQQA-----KVKVEQVKPMVLPMLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSP 2252
                 |.:|     :.|:.::|.:.:|.|......:..........:.:.|.:........:...
Zfish  2060 VLRSRNARAHGGLSRSKLREIKALSMPELDKLCTEDFTSDPGNVIFKTELEINPRRSIDPSSQCT 2124

  Fly  2253 VIHKVTQKPHHERFSSLD--SLASSSSGVSSTTQNVS-TTQETATEFGSFSSLGSNQ------SL 2308
            |:.:|         ||:|  :|.|:|:|.....|:.. :....:.:...||.|..|:      ||
Zfish  2125 VVTRV---------SSVDLGALGSTSNGEHHEIQDTGLSCWSISLKDLEFSPLDQNKVNDVLCSL 2180

  Fly  2309 ITAQDVQQIVEEADPPLKTPEAFIIVLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPAAKD 2373
            .|..||..:::||:...:..:....|:..:...:.:|.::|||.|.|.|.||:|::.:...|..:
Zfish  2181 PTKVDVTSLIQEANATSEVKDDVYFVILTKEQGAGLGFSIAGGVDLEQKSITVHRVFTRGVAGVE 2245

  Fly  2374 GRLKKGDRILAVNGMSMRGLTHRESISVL-KTPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSL 2437
            |.:.:|||||::||.|:..:||.|::|.| :|..|:..||:.:.:.                   
Zfish  2246 GTIHRGDRILSINGTSLSRITHGEALSCLHQTRLPKQALVIIQKDK------------------- 2291

  Fly  2438 NEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIA 2502
            |.:||                                          ||.|..||  :.|..|..
Zfish  2292 NAEPT------------------------------------------SPRQELSL--QTAVCTSP 2312

  Fly  2503 GIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFS 2567
            |.|                              ..||...........||..||:.|.:.|||||
Zfish  2313 GPR------------------------------ENIRGHKTSVEVGPDGALSVELQKTTAGLGFS 2347

  Fly  2568 IEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLPLGPV 2632
            ::||..|..|:|||.:|::|.||||:::..:..|||:|:|||.|...:...||||.:|.:..|||
Zfish  2348 LDGGKASAHGDRPLYIKRIFRGGAAEQSRVIDVGDELLAINGRSLQGLMHYDAWNIIKSVSEGPV 2412

  Fly  2633 KI 2634
            ::
Zfish  2413 QL 2414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bbgNP_648705.2 PDZ_canonical 90..177 CDD:467153 20/115 (17%)
PHA03247 <341..617 CDD:223021 62/317 (20%)
PTZ00341 <926..1237 CDD:173534 66/333 (20%)
PDZ6_PDZD2-PDZ3_hPro-IL-16-like 2330..2415 CDD:467243 30/85 (35%)
PDZ7_PDZD2-PDZ4_hPro-IL-16-like 2552..2636 CDD:467244 38/83 (46%)
pdzd2XP_003198698.4 None

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