DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bbg and dlg5a

DIOPT Version :9

Sequence 1:NP_001246755.1 Gene:bbg / 39583 FlyBaseID:FBgn0087007 Length:2637 Species:Drosophila melanogaster
Sequence 2:XP_005156738.1 Gene:dlg5a / 569065 ZFINID:ZDB-GENE-030131-3149 Length:1961 Species:Danio rerio


Alignment Length:2243 Identity:404/2243 - (18%)
Similarity:729/2243 - (32%) Gaps:832/2243 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   757 HSNMLPTIGEVEE---------EFSSLEPQSLTNGNLVKSEESKKLPKMEV-------------- 798
            |.|:|.:|.:.:.         ..|..|...|.......:|:.::|.||.:              
Zfish    13 HQNLLESITDADRLIELLSKSGSLSEQEAFELDQNCSSSAEKVEQLLKMLMNKQSDHFLELCVAL 77

  Fly   799 -------------NAGGLAQLTDDKIADHDASATRADTRDEVTTNQTQEISSSSSSSVKSQKTTT 850
                         |.||        .|||.:.:|.:    .::|..:...||||.|||.::.::.
Zfish    78 EKTYPHLYSALFSNGGG--------PADHHSGSTYS----VLSTMPSDSESSSSLSSVGTKASSP 130

  Fly   851 TTRVTTTKTSSSSSSSSCSSTVIPDVAFKL-QPYEERDDI-----LSEPITTIHEER-------- 901
            ...::.|:.:|.|         :..:.|:| |...|||::     |:.|.||..:.|        
Zfish   131 PPALSDTRPASDS---------LDTILFQLKQVTRERDELRKRLALASPGTTFDDCRPNSKPGHD 186

  Fly   902 --------------------------------------------RVLSEQKTLSE-----SRTRD 917
                                                        |:||||..|.|     .|...
Zfish   187 YERLKTQCTKAMADLQSLQNQHTKTLKRCEEAVKEADYYHIQHSRLLSEQTQLKEEMEVLKRENT 251

  Fly   918 ALTGEEQLVTSANSKSSSARFKKISSNDNLLDLGDEQDMQEQPLTATITQESSLRERLECPQDN- 981
            .||.|..     :.|.|....:::.|.|. .::.|.:..|:|     :.:|:...|.|....|. 
Zfish   252 KLTREHN-----HLKQSCEELRRLHSEDQ-REVADMRLQQQQ-----VIRENGSSEVLNKLYDTA 305

  Fly   982 ----QSIDRGTLTLSERGKQLSEKEGL--TTYTECETSEKESYLEGQQVLNGKGGFVSQDENSDQ 1040
                :.:.:....||   |:.|||...  |..:..|..|:|:....:|:    ...:.|.:.:.|
Zfish   306 MDKLEGVKKEYDVLS---KRYSEKVSSHNTDLSRLEQVEEENRRLQKQI----DALLKQRDTAIQ 363

  Fly  1041 PTYEREVSETLTIVNDGEKQVTKKLEQNKEIAGKKGAKLLKKTDEERRLEQEAQ-------KLIE 1098
              |:::.|.::...:..::::.|...||||:           ..|..||:.|..       |.::
Zfish   364 --YQQQWSTSMRRFDSVQQELNKASAQNKEL-----------QREMERLQSEVTRYKNFQLKAVK 415

  Fly  1099 SYQKVKKEAEKL---YKLELADDDQGF--------DLSAFEQAEEEDKPE---VSEEIKEVK--- 1146
            ..:|.|:|.:.:   |:|.:::.||..        :|.|.|...:....|   .|||::.::   
Zfish   416 DGEKYKEERDSVFNEYRLIMSERDQVIKEVDKLQTELEAAEARLKNTSSERMVASEELEALRQEL 480

  Fly  1147 DSQPVKVDIQIEEEVKTPNQVIGEVKVE-DVNKEIK------ETVQ----VSQQEIKKEVKVSHQ 1200
            :|..|..|..|.|..:...:...|||.: :..||:.      |||:    |:::|..:.:....|
Zfish   481 NSSLVDRDRAICERNELLEKYCHEVKDKAEAQKELSQACKDIETVREERDVARKERTEAIIQRDQ 545

  Fly  1201 ETKETFKSEEKDES---------NELKIVKEEVKVTHQDLREQIQEIEAVK-----VVHKEVKVI 1251
            ..:|.:::.:|.:|         .|:.|::::.:...|:|:|.:||.|..|     ...:..|::
Zfish   546 LLREYYQARQKQDSATLDMERANKEIDILRKQCEAMSQELKEAVQEAEVAKCRRDWAFQERDKIV 610

  Fly  1252 KESAKVTTTTSHKQATKEVIIS-----------KEDHKNDSAL---------------------- 1283
            .|...:.|...:.:..::..:|           ....:||:|.                      
Zfish   611 AERESIRTLCDNLRRERDRAVSDLADALRNLDDMRKQRNDAARELKELKEKMESQLDKEARFCQL 675

  Fly  1284 -------PAVSTTKVEIISPPLE-----DD-----LGYVLHKHIIFPQEKVKTAPTPLPKPKPKP 1331
                   .|:.|..:|..:..:|     ||     :|:.:.:.:                     
Zfish   676 MAHSSHDSAIDTDSLEWETEVVEFEKDRDDMDLKAMGFDIAEGV--------------------- 719

  Fly  1332 PVPTNKPKMP-------------------------------VNLTKPKSAPPPVPSKRSELSGSG 1365
                |.|.:|                               |:||. |.....:   ::.|:|.|
Zfish   720 ----NDPYLPGDCGIFVSRVDKGSIADGRLRVNDWLLKINDVDLTN-KDRKQVI---KAVLNGGG 776

  Fly  1366 GKPTPTQRRGSLETAQPPKPLERIIVGVEQRDEPEKPQPIINLASVDLPNVAPNSKQA-----TV 1425
            ......:||.||.        .|::..|.......|...|.....|.:..:||.|..|     |:
Zfish   777 LINMVVRRRKSLG--------GRLVTSVHINLIGHKDAGIALEGGVFVAGIAPGSPAAREGSLTI 833

  Fly  1426 ------------------ETTPVVEMPPDELQ----------------FESHQLPDDGEKEK--- 1453
                              |...::....|.|.                |||.:   :.||..   
Zfish   834 GDRLIAINGIALDNKSLSECEALLRGGRDSLALSLMKFFPQSTSGQNIFESLR---EAEKSNGRI 895

  Fly  1454 ---DLHQESNDLLSGSSSSSVTTPITTPILVSATSS------MDSVQSVIEVVNGMPIIS---NQ 1506
               |:|..::..|..:||:.      |.|....|:.      .|:.:|:.......||.:   |.
Zfish   896 HLTDVHSRNSRNLKHNSSTQ------TDIYSCDTAGERRKTRSDAEESLFSERKVFPISTLHPNT 954

  Fly  1507 QTDDDDIDEV----AAYDDGMHLEAEGTKDVRPVQEVTTL--TLDREHESDLGTLSNHHSNISSI 1565
            .....::..|    :|:.:..:..:|   .|.|  |..||  ||:::|..  ||..      ..:
Zfish   955 LRPASELGPVRYSASAFQEVCYTRSE---SVGP--ECVTLETTLEKKHSG--GTWP------KMV 1006

  Fly  1566 SGINASSNIPAATLISSSIK--KTSTEAATTK----PAAPQIPGKMELLSSNTGTTTTTTTAT-- 1622
            .|:..:::.||...|..|.|  |:..:|.|.|    |:.....|...|.:.:..|..|..|.:  
Zfish  1007 VGVAMTTDSPAQLSIYRSPKQRKSIFDADTFKRPDTPSKADYHGPQPLKADSAPTPPTPPTRSDS 1071

  Fly  1623 ---HHLHQATTTKQLLVQDYLSYASPPTYSRLPPDGHEFPPNFSEPLIMHSHPLKVTTELSYEIQ 1684
               .|.||.::|.:..: ..:|.:.|....|   :|:.:   |||..::.|.  |...|   :|.
Zfish  1072 FKFKHKHQGSSTSESTI-SAMSISEPKQEDR---NGNLY---FSEGKVLSSR--KSCEE---DIG 1124

  Fly  1685 KGGKDESSAP-PLPKTGPPATVPRKVYRQDLVINVEPAPSLTRD----YQRSLSGGTPRKPSDWR 1744
            :...:|.... |.||:.|  .:.|::..|:  |.::...|.:.|    .||.:...:|.:|.   
Zfish  1125 RMWAEEPEVKRPRPKSAP--ALRRRMTPQN--IPLQSFQSYSNDGDSVEQREMLRSSPNRPH--- 1182

  Fly  1745 KDEKSEKSVRDKIAMFSSNNELDAIPPAPATAPISSSFTRKPLNRSSENLLDSCSSSSA----PS 1805
                     |..:..                .|.|.:.|..|  .|:...|..||:.:|    |.
Zfish  1183 ---------RHSVGF----------------VPTSYNGTLPP--NSAHRGLAPCSAVTAVMKNPV 1220

  Fly  1806 LKTRAMSVENLNDVQRQYQLAKQLPQLHVADSMYSLNTATPTPSYASLPRRSHGGSYSSGVERRI 1870
            ...|:..|...|..    .:..|:.|.|          ..|:|        .|.|..|..     
Zfish  1221 YMVRSHRVHTNNCP----TVVSQINQQH----------THPSP--------QHQGQLSLD----- 1258

  Fly  1871 SFSGEGGDAANRKAAITNILEQRRRSLSKLRGLVIPERPQLLEPILDLPEIKSQVKAASGEDSTD 1935
                               |.|:|.:                    |..|.....:|:.|.:|..
Zfish  1259 -------------------LSQKRST--------------------DYSESSRSSRASHGTNSLP 1284

  Fly  1936 SGLGESHRSTVNRNCQLGAGGAANN--YRSILNTNQRRPLEQQLSQPPAKPPRTSLTPLQPRSMM 1998
            |            :.:|   |::||  ||:           :::..|.        ||..|||::
Zfish  1285 S------------SARL---GSSNNLQYRT-----------ERIKIPS--------TPRYPRSIL 1315

  Fly  1999 IPPPPPPLDQESDTDSVFSH----TARVATPPEKFALTRTLSSETNTSIASSNTSTLTSGSSAGS 2059
                      .||..|: ||    :..:.|||              .|..:..||:..|..|.||
Zfish  1316 ----------GSDRGSL-SHSECSSPSLITPP--------------LSPLNLETSSFASSQSQGS 1355

  Fly  2060 QASCSSLGSTPAVDLTRR-------------------VLKSQVINGEAVALSSRKSILASAKCRS 2105
            .::...:..:|.....||                   .|...:::||...:...|....|.    
Zfish  1356 ISTLPRISVSPVPTEERRKDRPYLEEPRNVMVHKGAEPLGISIVSGENGGIFVSKVTGGSI---- 1416

  Fly  2106 AKSRGQEEDNDSTDGEACSLANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDDS 2170
            |...|.|..:...:....:|.|...        ||.::.:|:|  .|.:..:|.|........:.
Zfish  1417 AHQAGLEYGDQLLEYNGINLRNATE--------QQARLIIGQQ--CDTITIMAQYNPHMYQLGNH 1471

  Fly  2171 SRRSDTPAKISAMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELRE 2235
            ||                                             .|::.||:..|:|.:   
Zfish  1472 SR---------------------------------------------SSSRLEPVSTQSTPQ--- 1488

  Fly  2236 KFERSAAAQAQTQNHSPVIHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVSTTQETATEFGSFS 2300
                 .:..|...||                |::|:|:....| :.|..:..||..|:.  .||.
Zfish  1489 -----GSGTATPDNH----------------STIDTLSEQDEG-TLTPSSKQTTPTTSP--NSFI 1529

  Fly  2301 SLGSNQSLITAQDVQQIVEEADPPLKTPEAFIIVLQRENPESSIGITLAGGSDYEAKEITIHKIL 2365
            .:.|..|                 .|.|||.::.:::...|  :||.|.||:   .:.|.:.::.
Zfish  1530 RMPSESS-----------------KKVPEARLVTVRKTQVE--LGIQLCGGN---LRGIFVERLE 1572

  Fly  2366 SNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRPEVVLVV------------TRSES 2418
            .::||.....:..||.||....::|:..|..|:...:..|...|.|.|            |..:.
Zfish  1573 DDSPARGADAVVPGDMILEYGSVNMKNKTVEEAYLEMLKPAETVTLRVQHRLDEFNQVKGTPGDG 1637

  Fly  2419 LVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGS 2483
            ..::||..:.:.           ||||...|::          |:..|.:        |.|: |:
Zfish  1638 FYIRALYDRVAE-----------TELDLSFKKD----------DILYVDD--------TLPN-GN 1672

  Fly  2484 VSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAAS 2548
            ........| ||:|:          ::.||   ::.:..::::....|::: .|::.:...:...
Zfish  1673 FGTWMAWQL-DENAQ----------KIQRG---QIPSKFMMDQEFYRRHSM-TELKDETGSSKTL 1722

  Fly  2549 GGGARCVEIVKDSCGLGFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGAST- 2612
            ...||                              :..|......|.:..::|.::::::..|| 
Zfish  1723 SAAAR------------------------------RSFFRRKHKHKRSSSKDGKDVVALDAISTD 1757

  Fly  2613 -------------SRMTRVDAWNYMKQLPLGPV 2632
                         .|:.::|..:....|.|||:
Zfish  1758 SIPFLDDCVSLAYQRVQKIDCTSPRPVLILGPL 1790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bbgNP_001246755.1 PDZ_signaling 90..177 CDD:238492
ATP-synt_B <1084..>1109 CDD:304375 8/31 (26%)
PDZ_signaling 2331..2413 CDD:238492 19/81 (23%)
PDZ_signaling 2553..2634 CDD:238492 12/94 (13%)
dlg5aXP_005156738.1 CARD 9..88 CDD:260018 11/74 (15%)
Takusan 128..211 CDD:282652 14/91 (15%)
Taxilin 295..627 CDD:286771 73/351 (21%)
RILP-like 338..460 CDD:304877 28/138 (20%)
SH3BP5 444..648 CDD:283045 39/203 (19%)
PDZ_signaling 696..783 CDD:238492 14/115 (12%)
PDZ_signaling 793..866 CDD:238492 12/72 (17%)
PDZ 1381..1463 CDD:214570 17/95 (18%)
dbPDZ_assoc 1461..1541 CDD:293216 24/168 (14%)
PDZ 1541..1623 CDD:214570 22/86 (26%)
SH3_DLG5 1639..1701 CDD:212794 18/105 (17%)
Guanylate_kin 1780..1949 CDD:279019 4/11 (36%)
NK 1794..1950 CDD:302627
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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