DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and pdzd3b

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_001124259.1	Gene:	pdzd3b / 566852	ZFINID:	ZDB-GENE-081022-151	Length:	524	Species:	Danio rerio

Alignment Length:	379	Identity:	80/379 - (21%)
Similarity:	137/379 - (36%)	Gaps:	96/379 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  2305 NQSLITAQDVQQIVEEADPPLKTPEAFIIVLQRENPESSIGITLAGGSDYEAKEITIHKILSNTP 2369
            |..::||.:.:::        ..|...:.||:||..| :.|..|....|.:...|.:  :.|..|
Zfish    27 NPVMVTADETERV--------WNPTPRVCVLRREERE-TFGFHLRVERDRQGHVIRL--LDSPGP 80

  Fly  2370 AAKDGRLKKGDRILAVNGMSMRGLTHRE------SISVLKTPRPEVVLVVTRSESLVVKALTKKR 2428
            ||:.| ||.|||:|.||...:..|.|.|      ...||.....|.|:    ||...::.:.|..
Zfish    81 AARSG-LKDGDRLLEVNEAFVENLEHTEVSGSQICFLVLDEKAYEQVV----SEGRDLREMAKAA 140

  Fly  2429 SSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLH 2493
            ...|      .:|..|.:.||..:       .:..:::..|..:...|.:|..|..
Zfish   141 RGEG------WRPPHLCHIRKDAH-------GMGFNILPVEGEKRKFAVSPVKGGA--------- 183

  Fly  2494 DEDAEATIAGIRARRQLSRGDAAKLS------TSELLERAAEARNAIAAE-------------IR 2539
                 |..||:|....|...|.|..|      .|:::::.:.....:..:             |.
Zfish   184 -----AERAGVRKGDHLIWIDGAMASELTHSAISKMVKKCSSHMTVLVIDSDTEKSYARRKMPIL 243

  Fly  2540 AQAEDAAASGGGARCVEIVKDSCGLGFSI---EGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNG 2601
            ....||.......:.:.:|....|.||.:   :||    .|....:|::|..|..|: ...|:.|
Zfish   244 PAMADAENMPYRPQRLHLVMGPDGYGFLLRQEKGG----AGRTVHMVREVDKGSPAE-LGGVKEG 303

  Fly  2602 DEILSINGASTSRMTRVD--------------------AWNYMKQLPLGPVKIC 2635
            :.:|.:||.||..::..|                    .:::..:|.|.|:..|
Zfish   304 EMLLEVNGESTDPLSHKDVVSNIRQSGQQVTLTTMTPQGYDFYTKLGLSPLLFC 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	29/87 (33%)
		PDZ_signaling	2553..2634	CDD:238492	22/103 (21%)
pdzd3b	NP_001124259.1	PDZ_signaling	44..118	CDD:238492	25/77 (32%)
		PDZ	148..227	CDD:214570	16/99 (16%)
		PDZ_signaling	264..336	CDD:238492	18/76 (24%)
		PDZ	393..473	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900