DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and lnx1

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_005160562.1	Gene:	lnx1 / 561226	ZFINID:	ZDB-GENE-030131-9439	Length:	769	Species:	Danio rerio

Alignment Length:	728	Identity:	146/728 - (20%)
Similarity:	235/728 - (32%)	Gaps:	243/728 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2008 QESD-TDSVFSHTARVATPPE-----KFALTRTLSSE---TNTSIASSNTSTLTSGSSAGSQASC 2063
            ||.| |||. |.....|.|.|     ..||   ||.|   .|.:...|......|||:....|..
Zfish   161 QEGDCTDST-SELTLAALPGEGCPSSAIAL---LSDEPGLVNPAYEPSVEDNSQSGSTTSLAARS 221

  Fly  2064 SSLGSTPAVDLTRRVLKSQVINGEAVALSSRK--------SILASAKCRSAKSRGQEEDNDS--- 2117
            .|             .||:..|.:..::.||.        |:|...|..:|.:....|:.|:
Zfish   222 GS-------------RKSEYRNFDRTSVRSRSFRRLNRAFSVLRRTKSGTAVANDTTEERDNLRN 273

  Fly  2118 -------------------TDGEACSLANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVEL 2163
                               .|||..|:...|..|.....:   .|..|.:..:.:::....|.|.
Zfish   274 ANIPAEGELFALPQLHHLIPDGEVTSIKITRADPCEPLAI---SIVGGNETPLVRILIQDIYREG 335

  Fly  2164 TSDTDDSSRRSDTPAKISAMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQ 2228
            ....|......|...|::.:.|...        |:..|...::|  |..|           |:..
Zfish   336 VIARDGRLLPGDMILKVNGIDISNV--------PHCYAVAALKQ--PCTL-----------LRLT 379

  Fly  2229 TTAELREKFERSAAAQAQTQNHSPV--------------IH--------------KVTQKPHHER 2265
            ...|.|.::        ::.:|||.              :|              |:.::|....
Zfish   380 VLREQRHRY--------RSHHHSPTEAFPAHTATIRDDSLHVVLVKRAPDEQLGIKLVRRPDEHG 436

  Fly  2266 ---FSSLDSLASSSSGVSSTTQNVSTTQETATEFGS--------------FSSLGSNQSLITAQD 2313
               |..|:...::..|.......|.........:|:              ...:.|.|:.|.|.|
Zfish   437 VFIFHLLEGGLAARDGRLRVDDRVLAINGHDLRYGAPEHAALLIQASEDRVHFIVSRQTHIPAPD 501

  Fly  2314 VQQIVE---EADPP-------------LKTPEAF--IIVLQRENPESSIGITLAGGSDYEAKEIT 2360
            :.|...   |..||             .:.|..:  .:.|.:| |..|:|:|:|||......::.
Zfish   502 ILQEAPWNMEGPPPYSPVDIEHTLLDSCQKPACYEKTVTLLKE-PHDSLGMTVAGGMSSRGWDLP 565

  Fly  2361 IH--KILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVVKA 2423
            ::  .:..|....::|.::|||.:|.|||:.:.|:|..|:::.||.....|||       .|::.
Zfish   566 VYVTNVDPNGVVGQEGSIRKGDILLNVNGVDLTGVTRSEAVANLKNTSSPVVL-------QVLEM 623

  Fly  2424 LTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPST-GSVSPP 2487
            .....|||..:..|:                                  ||.|.:||: |.|..|
Zfish   624 RPPNESSLDCMPPLH----------------------------------SPCALSPSSPGDVKLP 654

  Fly  2488 QPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGA 2552
            .|   :|:.|...::.::..|.|                                         .
Zfish   655 PP---NDDYAPLWVSWLQLPRHL-----------------------------------------Y 675

  Fly  2553 RCVEIV---KDSCGLGFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSR 2614
            .|.:||   ..|..|||||.||.:....|:...::.:..|..|....::|.||.:|.:||.||..
Zfish   676 CCKDIVLRRSTSGSLGFSIVGGQEELNCNQSFFIRSIVEGTPAYNDGRIRCGDILLEVNGKSTWG 740

  Fly  2615 MTRVDAWNYMKQL 2627
            ||.......:|:|
Zfish   741 MTHTALVRLLKEL 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	26/85 (31%)
		PDZ_signaling	2553..2634	CDD:238492	26/78 (33%)
lnx1	XP_005160562.1	RING	57..93	CDD:214546
		PDZ_signaling	297..381	CDD:238492	17/107 (16%)
		PDZ_signaling	411..491	CDD:238492	8/79 (10%)
		PDZ_signaling	536..621	CDD:238492	26/92 (28%)
		DegQ	<548..621	CDD:223343	23/79 (29%)
		PDZ_signaling	678..762	CDD:238492	25/76 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10107
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900