DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and grid2ipb

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	1228	Identity:	238/1228 - (19%)
Similarity:	374/1228 - (30%)	Gaps:	417/1228 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ATINDDYITVVEVDDPTSNPKDRLKKLVKRQSSVAEDSSFITVL----TINEMELLQQRKKEED- 74
            |::..|.:|..|.....||.:..:.|..:::...|...|.|..:    ::.|.:...:|.:.:|
Zfish   225 ASVLPDILTTEEQQQLISNIRIFIPKKHRQRFDEAVSQSLINRMCRSKSLGEPQNRLRRSRSQDH 289

  Fly    75 ----VGS----------GSSPTMEEQI------------------ENVTVFRLPGERLGFGLKFQ 107
                .||          |..|...::.                  ..:.|:|  |:: .||...:
Zfish   290 HERPQGSKRASSVPRDTGDEPAQNDRTLRKSNTMIPTQYVSGVNQRTIRVYR--GKK-SFGFTLR 351

  Fly   108 GGTRSTELVQKLYIQSCAADSPASKVSTSWGNLREGDEIVSIDGRDVRELTRIDCVRGLKDNVAI 172
            |..       .::|.|....|||...     .|:.||.|:.::|.|:|..:....|..|:.:.|:
Zfish   352 GHA-------PVWIDSVMPGSPAEAC-----GLKTGDRILFLNGLDMRNCSHEKVVSMLQGSGAM 404

  Fly   173 -KLVVRNGHGQKPPSEEDP------------------------------------QQQEHLSI-- 198
             .|||..|....|.|:.:|                                    ||.|||..
Zfish   405 PSLVVEEGPVDYPQSDSEPEETPSAPRSRSPALSSLQWVAEILPPSIRVHGRTFSQQLEHLLTLQ 469

  Fly   199 -------------------TLNAQPPPPPPVPPRKLV-----------RRQNSKENQAQLLIEKP 233
                               ||.....|....|.::|:           .:::.|...|:.|..|.
Zfish   470 ERYTICKALETFFQHRNVDTLIVDVFPVLDTPAKQLIWQFIYQLLTYEEQEHCKTKIARFLGFKS 534

  Fly   234 LTPPPDAEYYLNLLTESIKAGS--------ESDD----TASTISTVIDKFS-------------- 272
            ..|...||.:....:..:...|        .|||    |...:.|..|..:
Zfish   535 AEPEVGAETHRRSSSMRVSGTSHKNTVRERSSDDCIIGTHLGMGTFTDPVTPEERQCGDGTSFPE 599

  Fly   273 -------------VGSNY--SSDSSLNGHELAKV----LQPFTLLEQEFLPLEQPLGHPKL---- 314
                         :|:.|  .|..||..|...:.    |.......|.|  .....|:.|.
Zfish   600 SPDLSHMTGVYTELGNVYPVKSSQSLQSHSSPRAAGMGLAESNTYTQSF--THSTAGNRKSGLSL 662

  Fly   315 ----LIPG---NNYENVEFKTEKVNVYENVELRSPETTPTPKPRVQLATVEPKKRSIIPMPRKIP 372
                ..||   ..|:......:.|:....|.|.||..:|.|...:          |.:|..||:.
Zfish   663 TWTDSFPGPQFETYQQTVASPDSVDSNPYVSLDSPPASPLPSDEL----------SPLPQRRKLF 717

  Fly   373 TPTKLPIEVTPPR-------VPILEEPKTPTNNKVDSPKTPTNELKESPI----SATKIPKAKFS 426
            |.::      |||       :..|.|......|.||..|...|:.:|...    ....:|. :.|
Zfish   718 TFSR------PPRSRDTDKFLDALSEQLGHRVNIVDDFKGGENDYEEMSFQDEQEVNMLPH-ELS 775

  Fly   427 RAKTEGEIKL-------------HLPAPKQQSP---------QSKSRIPIV-----STPTAQKTV 464
            .|.:|.....             |:|.|.|..|         .|.|.:||.     ..|.|.:..
Zfish   776 SASSEDHSSSDDSTSVSYSSGSDHIPPPPQSPPPPPPPLQFTDSPSPLPITPEHLPQPPPAFQHH 840

  Fly   465 PKPVSPTMNGTPLSSNIPRLLQKQKSETDLKLNLYRSKSKESSPRPPLQRANSAEAPERTFIPVL 529
            |....|.....|..:|.|.|.:...:..:|:..  .|..:.|||:|..|             |:|
Zfish   841 PIIAPPPPPPRPFLANRPSLHKVLPTREELRAQ--HSHPRRSSPQPSSQ-------------PIL 890

  Fly   530 LNGNSKSSNSLESVSSIGSSSSGNSVRSPKGPKPKPPERVQSLQKTQIPK---LQALPTTPPQQI 591
            .....|:...|:|              ||. ..|:||.......:.|.|.   .|:..||.|:..
Zfish   891 QLHQPKAHPILQS--------------SPH-TSPQPPHTSAQHTRLQHPSQSIYQSQQTTVPRTS 940

  Fly   592 PKL----------SMQTF------KQSPPTP-------RSTPVGTPSP--TSNREIRFKIQTYES 631
            |.|          |.|:|      |..||.|       ...|:..|||  :.|..:..|...:|.
Zfish   941 PSLTKQKSLHSQPSQQSFEGTLSSKVPPPPPPPLPPPCDPPPLPKPSPKASDNNHMSVKRLRWEQ 1005

  Fly   632 KTQDEDKL-PSLFDLVHSQENDKDKDRDSDSLK----------THNSITALLAAAAAEAADLSRE 685
            ....|..: ..|.|       |.|..:.||.:|          ..|||:.
Zfish  1006 VENSEGTIWGQLGD-------DPDYHKLSDMVKYLDLDLYFGTQRNSISL--------------- 1048

  Fly   686 SPPPLVVGKCMK---IVDDTNTTTCYTSS-------SSGEEDEDDLDASNREYICEDGEKLGPPE 740
             |.|..:.:.:|   :|:..:....|.:|       .:.:|..|.|       :....|:|.|..
Zfish  1049 -PEPTFLPENLKKKDVVEILSHKKAYNASILIAHLKLAPKELRDIL-------MTMSTERLEPAH 1105

  Fly   741 ----LINGPGPSEAYFNMFWHSNMLPTIGEVEEEF---SSLEPQSLT--NGNLVKSEESKKLPKM 796
                |:..|...|.  ..|.|.:..|......::|   ..|.|:..|  ...|.|:...:|..:|
Zfish  1106 IKQLLLYAPDDEEV--KQFQHYDQDPAKLSEPDQFVLQMLLVPEYKTRLRSLLFKTTVQEKTEEM 1168

  Fly   797 EV-------------NAGGLAQLTDDKIADHDASATRADTRDEVTTNQTQEISSSSSSSVKSQKT 848
            ..             |:..||     ||.:...:........:..||:|...           |.
Zfish  1169 RAAYECIYKASLELKNSKRLA-----KILEFVLAMGNYLNNGQPKTNKTTGF-----------KI 1217

  Fly   849 TTTTRVTTTKTSSSSSSSSCSSTVIPDVAFKL-QPYEE----RDDILSEPITTIHEERRVLSE-- 906
            ...|.:.||||...      .||.:..:|..| |.:.|    ..|:::.|:.....:|.:.::
Zfish  1218 NFLTELNTTKTVDG------KSTFLHILAKSLCQHFPELLGFSRDLITVPLAAKVNQRTITADLS 1276

  Fly   907 --QKTLSESRT---RDALTGEEQL--------------VTSANSKSSSA--RFKKISS 943
              ..|:.:.||   :...|.|::.              |.|.:|....|  .|.|::|
Zfish  1277 DVHSTIQDIRTACVKIPATAEDRFAAVMSSFLENCHPAVQSLDSLQQRAMDEFHKVAS 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492	23/87 (26%)
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492
		PDZ_signaling	2553..2634	CDD:238492
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492
		PDZ_signaling	80..156	CDD:238492
		HN_L-delphilin-R1_like	183..262	CDD:259820	8/36 (22%)
		PDZ_signaling	335..410	CDD:238492	23/89 (26%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	12/78 (15%)
		FH2	995..1360	CDD:280362	74/394 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900