DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and grip1

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_009298419.1	Gene:	grip1 / 558006	ZFINID:	ZDB-GENE-041210-125	Length:	1191	Species:	Danio rerio

Alignment Length:	867	Identity:	161/867 - (18%)
Similarity:	290/867 - (33%)	Gaps:	280/867 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1859 GGSYSSGVER----RISFSGEGGDAAN----------RKAAITNILEQRR-RSLSKLRGLVIPER 1908
            |.:.|.|:::    |:|...:||.||.          :.....|:.:.|. ..:|.|:.  :.||
Zfish    91 GLTVSGGIDKDGKPRVSNLRQGGIAARSDQLNVGDYIKSVNGINLTKFRHDEIISLLKN--VGER 153

  Fly  1909 PQLLEPILDLPEIKSQVKAASGEDSTDSGLGESHRSTVNRNCQLGAGGAANNYRSIL------NT 1967
             .:||...:||.:..|            |.|     .:.:|.::......|.:..::      :.
Zfish   154 -VVLEVEYELPPVSVQ------------GSG-----VMFKNVEVTLHKEGNTFGFVIRGGAHEDR 200

  Fly  1968 NQRRPLEQQLSQPPAKPPRTSLTPLQPRSMMIPPPPPPLDQES---------DTDSVFSHTARVA 2023
            |:.||:              ::|.::|..        |.|:|.         ..|.:..|.|..|
Zfish   201 NKSRPV--------------TITTIRPGG--------PADREGTIKPGDRLLSIDGIRLHGASHA 243

  Fly  2024 TPPEKFALTRTLSSETNTSIASSNTSTLTSGSSAGSQ---ASCSSLGSTPAVDLTRRVLKSQVIN 2085
               |..::.:....|. |.:...:.|.:.|.::|...   ....|:||:..:.|:    .|...|
Zfish   244 ---EAMSILKQCGQEA-TLLIEYDVSVMDSVATASGPLLVEVAKSMGSSLGLALS----TSMYCN 300

  Fly  2086 GEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDGEACSLANR---------------------- 2128
            .:.:.:...|....:.:|.:..:.......|.|..|.|:||..
Zfish   301 KQVIIIDKVKPASIADRCGALHAGDHILSVDGTSMEYCTLAEATQLLASASEHVKMEILPHHQTR 365

  Fly  2129 -RMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTS---DTDDSSRRSDTPAKISAMFIDEER 2189
             .:|.....|:|:....|..:...:...|...|....:   |...|..:..:|:       :...
Zfish   366 LALKGPEHVKVQRSTRPLPWESGTNNNSNFLPYQHYNTYHPDQSHSQAKKTSPS-------NPPL 423

  Fly  2190 KASFKGDPNQQAKVKVEQVKPMVLP-MLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSPV 2253
            .:||  .|...:...:..:....|| .:.|::.|..:       :|.|.::
Zfish   424 GSSF--SPTSMSAYSLSSLNMNTLPRTMYPTSPRGTM-------MRRKLKK-------------- 465

  Fly  2254 IHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQSLITAQDVQQIV 2318
                      :.:.|..|||||:.|::....:..||:.|..   |.|.:|
Zfish   466 ----------KDYKSSMSLASSTVGLAGQVVHTETTEVTLI---SDSIMG--------------- 502

  Fly  2319 EEADPPLKTPEAFIIVLQRENPESSIGITLAGG---SDYEAKEITIHKILSNTPAAKDGRLKKGD 2380
                                     .||.|.||   ::..:....|..|..::||.:.|.|:.||
Zfish   503 -------------------------FGIQLQGGVFATETLSSPPLIAYIDPDSPAERCGILQIGD 542

  Fly  2381 RILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSLNEKPT-EL 2444
            |||::||:.....|..|:..:|:.                              ||:..|.| |:
Zfish   543 RILSINGIPTEDSTLEETNQLLRD------------------------------SSITSKVTLEI 577

  Fly  2445 DYE-------RKRNYH-KASRSLDLDLDLV-----SNEAGESPVATTPSTGSVSPPQPASLHDED 2496
            :::       ....:| |..:...::|.:.     |.:.|::.:.:....|||: .:..:|...|
Zfish   578 EFDVAESVIPSSGTFHVKLPKKPGVELGITISSPSSRKPGDALIISDIKKGSVA-HRTGTLELGD 641

  Fly  2497 AEATIAGIRARRQLSRGDAAKL----------------STSELLERAAEARNAIAAEIRAQAEDA 2545
            ....|..||. ...|..||.::                ..|.:|...:..||| ...:...|::.
Zfish   642 KLLAIDNIRL-DNCSMEDAVQILQQCEDLVKLKIRKDEDNSGVLRAGSVDRNA-RVLLACVADEQ 704

  Fly  2546 AASGGGARCVEIVKDSCGLGFSIEG---GFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSI 2607
            ..||.....||:.:....||.:|.|   .||      |:|:..:..||.|::|..:..||.||:|
Zfish   705 ETSGAIIYTVELKRYGGPLGITISGTEEPFD------PIIISSLTKGGLAERTGAIHIGDRILAI 763

  Fly  2608 NGASTSRMTRVDAWNYMKQLPL 2629
            |.            |.:|..||
Zfish   764 NS------------NSLKGKPL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	21/84 (25%)
		PDZ_signaling	2553..2634	CDD:238492	24/80 (30%)
grip1	XP_009298419.1	PDZ_signaling	79..159	CDD:238492	17/70 (24%)
		PDZ_signaling	178..261	CDD:238492	16/108 (15%)
		PDZ_signaling	276..359	CDD:238492	14/86 (16%)
		PDZ_signaling	490..578	CDD:238492	32/160 (20%)
		PDZ_signaling	591..675	CDD:238492	16/85 (19%)
		PDZ_signaling	711..792	CDD:238492	24/81 (30%)
		PDZ_signaling	1053..1133	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810