DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and pdzd3a

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_685398.3	Gene:	pdzd3a / 557269	ZFINID:	ZDB-GENE-080430-1	Length:	520	Species:	Danio rerio

Alignment Length:	498	Identity:	88/498 - (17%)
Similarity:	164/498 - (32%)	Gaps:	169/498 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2205 VEQVKPMVLPMLLPSAKREPLK-QQTTAELREKFERSAAAQAQTQNHSPVIHKVTQKPHHERFSS 2268
            |.||:|.      .||:|..|: .....|:.|.|       ...:.||.|:.||
Zfish    90 VRQVEPW------SSAERAGLRIGDHVLEVNEDF-------VDDKEHSTVVLKV----------- 130

  Fly  2269 LDSLASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTPEAF-- 2331
                                         ..|.|.....:::|||.:..|.|....|....::
Zfish   131 -----------------------------QASGLKLYLLVLSAQDYEFAVSEGRDLLSVARSYRP 166

  Fly  2332 -------IIVLQRENPESSIGITL-----AGGSDYEAKEITIHKILSNTPAAKDGRLKKGDRILA 2384
                   :..:.:| |...:|:::     |.|. |....:|      :.||.:.| ::.|||::.
Zfish   167 EGCSRPRLCHITKE-PGCGLGLSIIPIEGARGR-YRLNPVT------DGPAERAG-IQNGDRLIW 222

  Fly  2385 VNGMSMRGLTHRESISVLKTPRPEVVLVV--TRSESL-------VVKA---------------LT 2425
            :||:|:..:::.....::|.....:.::|  :|||.:       ::.|               ||
Zfish   223 INGVSISVISYAALAKMVKKCEKHLTVLVIDSRSEEIYNRMGLPIIPAFAETHNLPYRPKTLHLT 287

  Fly  2426 KKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLD----LDLVSNEAGESPVATTPSTGSVSP 2486
            :.....|.|         |..|:.|:...|....::|    .:....|.||..:|....
Zfish   288 QGPQGYGFL---------LRQEKLRSGRIAHILREIDPCSPAETAGMEDGEIVLAVNGE------ 337

  Fly  2487 PQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIA---------------A 2536
                .:.|.:.|..::.||     ..|....|:|..:..|....:.|::               |
Zfish   338 ----QVEDAEHEGIVSKIR-----QSGQQVTLTTISIAGRDFYTQLAMSPLLFYDEHIPKCEPFA 393

  Fly  2537 EIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLGNRP-LIVKKVFMGGAAQKTNQVRN 2600
            ....:..:...:....|..|:.|:..|.||::     ..:.|:| ..:.:|..|...::.. :|.
Zfish   394 TPALEHPEGHQNPPQPRLCELHKEGTGFGFNL-----GCVENKPGTYIGQVVSGSTGERAG-LRK 452

  Fly  2601 GDEILSINGASTS------------------RMTRVDAWNYMK 2625
            .|.::.:||.:..                  |:..||...|.|
Zfish   453 WDVLIEVNGQNVEDEYFDEVVRLITGGGTPLRLLVVDGLQYDK 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	17/95 (18%)
		PDZ_signaling	2553..2634	CDD:238492	19/92 (21%)
pdzd3a	XP_685398.3	PDZ_signaling	61..142	CDD:238492	18/104 (17%)
		PDZ_signaling	172..252	CDD:238492	17/88 (19%)
		PDZ	280..363	CDD:214570	19/106 (18%)
		PDZ	408..490	CDD:214570	16/87 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900